Abstract: Systems and methods are described for executing a query of raw machine data that is stored at a remote data store that may store heterogeneous data. The system can determine the directories or file types that may store event data and may instruct one or more worker nodes to access files that may store events based on the determined directories of file types. Further, the system may exclude files at the remote data store that may not be identified as potentially storing events enabling a query that implicates a heterogeneous data store to be efficiently executed.

Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.

Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.

Abstract: Methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant are described, which methods comprise the sequential steps of: (a) passing the composition through an ion exchange membrane, where the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pI of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and the at least one contaminant, and (b) recovering the purified polypeptide from the effluent.

Abstract: Methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant are described, which methods comprise the sequential steps of: (a) passing the composition through an ion exchange membrane, where the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pI of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and the at least one contaminant, and (b) recovering the purified polypeptide from the effluent.

Abstract: Systems and methods are described for executing a query of raw machine data that is stored at a remote data store that may store heterogeneous data. The system can determine the directories or file types that may store event data and may instruct one or more worker nodes to access files that may store events based on the determined directories of file types. Further, the system may exclude files at the remote data store that may not be identified as potentially storing events enabling a query that implicates a heterogeneous data store to be efficiently executed.

Abstract: Systems and methods are described for distributed processing a query in a first query language utilizing a query execution engine intended for single-device execution. While distributed processing provides numerous benefits over single-device processing, distributed query execution engines can be significantly more difficult to develop that single-device engines. Embodiments of this disclosure enable the use of a single-device engine to support distributed processing, by dividing a query into multiple stages, each of which can be executed by multiple, concurrent executions of a single-device engine. Between stages, data can be shuffled between executions of the engine, such that individual executions of the engine are provided with a complete set of records needed to implement an individual stage. Because single-device engines can be significantly less difficult to develop, use of the techniques described herein can enable a distributed system to rapidly support multiple query languages.

Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.

Abstract: Methods of rehabilitation of neurological disorders, including neurological deficits associated with neurotraumas, such as stroke and traumatic brain injury, and with muscle disorders, that includes administering to a subject a MAO-B inhibitor.

Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.

Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.

Abstract: Systems and methods for treating patients to improve cognitive or motor abilities are disclosed. One exemplary method comprises receiving a visiting patient at a clinic, administering an augmenting agent to the visiting patient, training the visiting patient to stimulate neuronal activity, and recording augmenting agent administration data and patient training data associated with the visiting patient. The augmenting agent may comprise a phosphodiesterase 4 (PDE 4) inhibitor. The method may further comprise receiving a returning patient at the clinic, administering the augmenting agent to the returning patient, training the returning patient to stimulate neuronal activity, and recording augmenting agent administration data and patient training data associated with the returning patient.

Abstract: While a device is offline, usage data is tracked on the device. The usage data is uploaded to a server after the device is again connected to a network. Applications that run on mobile devices typically embed a browser to display content. Unfortunately, mobile devices also frequently disconnect from the associated network. A system tracks usage data by using JavaScript in the browser to communicate with the native device, which then buffers the usage data for future upload. This is done by installing, in each application, a “protocol handler” that listens for a request over a particular protocol. The protocol handler intercepts the requests and stores the usage data locally on the device. Subsequently, when the device detects network connectivity, the device uploads the data to servers that collect data for aggregation and presentation.

Abstract: While a device is offline, usage data is tracked on the device. The usage data is uploaded to a server after the device is again connected to a network. Applications that run on mobile devices typically embed a browser to display content. Unfortunately, mobile devices also frequently disconnect from the associated network. A system tracks usage data by using JavaScript in the browser to communicate with the native device, which then buffers the usage data for future upload. This is done by installing, in each application, a “protocol handler” that listens for a request over a particular protocol. The protocol handler intercepts the requests and stores the usage data locally on the device. Subsequently, when the device detects network connectivity, the device uploads the data to servers that collect data for aggregation and presentation.

Abstract: Methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant are described, which methods comprise the sequential steps of: (a) passing the composition through an ion exchange membrane, where the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pI of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and the at least one contaminant, and (b) recovering the purified polypeptide from the effluent.

Abstract: A method and apparatus for geographic specific search results in response to a search request having an address field includes retrieving map portion having the address thereon. The method and system further includes determining entities in geographic relation to the address and generating an entity listing, where the entity listing includes listing of the various entities. These entities may represent any type of business, club, library, government building/office, or other locations. The method and apparatus further includes determining various descriptive terms that relate to the entities which are in geographic relation to the address. These terms include hyperlinks to corresponding entity listings. The method and apparatus further includes generating a visual display that includes: the map portion with the address displayed thereon; an entity portion that includes the entity listing; and a term portion with a taxonomical display of the plurality of terms.

Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.

Abstract: An apparatus such as a television signal receiver, radio or other device provides an emergency alert function. According to an exemplary embodiment, the apparatus includes a processor operative to detect a first condition wherein signal strength on a selected channel frequency associated with the emergency alert function exceeds a predetermined threshold, and to detect a second condition wherein a broadcast test associated with said emergency alert function is passed. A visual indicator is operative to provide a predetermined output if the first and second conditions are detected.

Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.