Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include detecting light with a light detection system having a photodiode and an amplifier, determining responsivity of the photodiode over a plurality of wavelengths of light and adjusting one or more parameters of the amplifier in response to the responsivity of the photodiode over the plurality of wavelengths of light. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodiode and an amplifier for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.

Abstract: Disclosed herein are methods for producing high density cellular arrays. In some embodiments, the methods comprise: providing a sample comprising a plurality of cells; and introducing the plurality of cells in the sample into microwells of a microwell array to produce a cellular array, wherein the microwell array comprises 500 or more microwells per inch2, and wherein 25% or more of the microwells of the cellular array comprise a single cell. The disclosed methods can be used for producing a high density synthetic particle array and a high density reagent array.

Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include detecting light with a light detection system having a photodiode and an amplifier, determining responsivity of the photodiode over a plurality of wavelengths of light and adjusting one or more parameters of the amplifier in response to the responsivity of the photodiode over the plurality of wavelengths of light. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodiode and an amplifier for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.

Abstract: Disclosed herein are methods for producing high density cellular arrays. In some embodiments, the methods comprise: providing a sample comprising a plurality of cells; and introducing the plurality of cells in the sample into microwells of a microwell array to produce a cellular array, wherein the microwell array comprises 500 or more microwells per inch2, and wherein 25% or more of the microwells of the cellular array comprise a single cell. The disclosed methods can be used for producing a high density synthetic particle array and a high density reagent array.

Abstract: An enhanced detection system can eliminate use of a sheath fluid by selecting which particles that pass through an sensing region to detect parametric characteristics thereof based upon position of each particle while it is in a sensing region relative to one or more predetermined positions, such as an in-focus position relative to one or more light beams directed into the sensing region, to enhance accuracy and robustness of particle parametric characteristics detection.

Abstract: An enhanced droplet flow cytometer system and method allows for improvement in performance, maintainability, and adaptability to operational conditions encountered. The enhanced system uses an oscillator positioned and configured to impart vibrational energy transverse to fluid flow. In some implementations, an oscillator provides a radial pressure field to the sheath fluid to avoid exciting resonances in the system. Implementations use removable recessed nozzles to aid in cleaning and replacement without imparting appreciable turbulence to fluid flow during operation.

Abstract: An integrated evaluation and simulation system for advanced naval gun systems interactively evaluates concept design decisions and design requirements in the context of a virtual representation of an operational advanced naval gun system. The combat effectiveness of an advanced naval gun system may also be concurrently tested by virtual simulation. A computer system is programmed to implement a causal network model comprising an integrated collection of analysis models for creating a virtual representation of an advanced naval gun system. The integrated evaluation and simulation system also includes a user interface operatively connected to at least the computer system, for selectively inputting data into the causal network model and receiving information therefrom, and preferably at least one virtual simulation system.

Abstract: The invention provides an improved propellant system for firing projectiles in large caliber guns. Strips of energetic propellant are placed in the cartridge case so that the lengths of the strips are parallel to the length of the cartridge. Preferably, the strips are placed in a radially symmetric pattern. The strips provide passageways that allow ignition gasses to flow radially in the cartridge case and along the length of the cartridge case.