Abstract: The present invention includes a device and method used for automated sampling and measurement of blood analytes, such as blood glucose, from a subject patient. The blood sampling and measurement may be performed automatically by the device on a patient without requiring user intervention or supervision. The sampling and measuring device comprises a sensor unit operably attached to a replaceable cartridge. The replaceable cartridge provides a disposable body that contains a number of lancets and test strips used for collecting and analyzing a blood sample. The sensor unit contains an actuator and microcontroller that fires the lancet and collects blood sample data from the test strips. The blood sampling and measurement process may be initiated by an external controller or may be autonomously initiated in a specific interval. A further embodiment involves integration and use of the sampling and measurement device within an automated monitoring and treatment system.