Abstract: Provided is a glaucoma valve, a casing for containing a glaucoma valve and a glaucoma drainage device including the glaucoma valve and/or the casing. The valve includes a flow channel having an inlet and an outlet and a valve member connected to the outlet of the flow channel. The valve member may be formed from a degradable polymer or a combination of degradable polymer and non-degradable polymer. The valve may have a first flow channel, the interior of which may be coated with a degradable polymer, such that in use, the polymer degrades to allow a greater flow of fluid through the flow channel. The valve may include a second flow channel, which may be arranged in parallel to the first flow channel. The casing may be formed from a degradable polymer, such as a biodegradable polymer.

Abstract: The invention relates to a multilayered nanoparticle for delivery of RNA to a cell and methods of manufacturing and using the same. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the at least one of the negatively charged polymer layers is RNA.

Abstract: The present invention is directed to a liposomal formulation for ocular drug delivery comprising (i) liposomes comprising at least one lipid bilayer, and (ii) a prostaglandin drug and/or a prostaglandin derivative associated in the liposomes, wherein the liposomes have a mean diameter of less than 2???. The present invention is also directed to a pharmaceutical comprising the liposomal formulation and a method of producing the liposomal formulation for ocular drug delivery. Additionally, the present invention is directed to a method of treating or preventing an ocular disease, comprising administering the liposomal formulation or the pharmaceutical composition to a subject in need thereof.

Abstract: Provided is a biodegradable ocular implant for sustained drug delivery, including a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

Abstract: The invention relates to a multilayered nanoparticle for delivery of RNA to a cell and methods of manufacturing and using the same. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the at least one of the negatively charged polymer layers is RNA.

Abstract: Provided is a biodegradable ocular implant for sustained drug delivery, including a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

Abstract: A system and method processes messages related to nodes in a network and provides reports according to those messages to allow analysis of the network.

Abstract: The present invention relates to methods and compositions for the modulation of wound healing and/or the production of extracellular membrane components by modulating the activity and/or amount of secreted protein acidic and rich in cysteine (SPARC) protein. The invention further provides methods for identifying compounds useful in the above-mentioned methods and compositions.

Abstract: The present invention is directed to a liposomal formulation for ocular drug delivery comprising (i) liposomes comprising at least one lipid bilayer, and (ii) a prostaglandin drug and/or a prostaglandin derivative associated in the liposomes, wherein the liposomes have a mean diameter of less than 2???. The present invention is also directed to a pharmaceutical comprising the liposomal formulation and a method of producing the liposomal formulation for ocular drug delivery. Additionally, the present invention is directed to a method of treating or preventing an ocular disease, comprising administering the liposomal formulation or the pharmaceutical composition to a subject in need thereof.

Abstract: Various embodiments of the invention relate to a glaucoma valve, a casing for containing a glaucoma valve and a glaucoma drainage device comprising the glaucoma valve and/or the casing. The valve includes a flow channel having an inlet and an outlet and a valve member connected to the outlet of the flow channel. The valve member may be formed from a degradable polymer or a combination of degradable polymer and non-degradable polymer. Various embodiments of the invention relate to a glaucoma valve, the valve having a first flow channel. The interior of the first flow channel may be coated with a degradable polymer, such that in use, the polymer degrades to allow a greater flow of fluid through the flow channel. In some embodiments, the valve includes a second flow channel, which may be arranged in parallel to the first flow channel. The first flow channel may be completely sealed with the polymer such that in use, the polymer degrades to allow fluid to flow through the first flow channel.

Abstract: The present invention relates to a biodegradable ocular implant for sustained drug delivery, comprising a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

Abstract: The present invention relates to methods and compositions for the modulation of wound healing and/or the production of extracellular membrane components by modulating the activity and/or amount of secreted protein acidic and rich in cysteine (SPARC) protein. The invention further provides methods for identifying compounds useful in the above-mentioned methods and compositions.

Abstract: The present invention relates to methods and compositions for the modulation of wound healing and/or the production of extracellular membrane components by modulating the activity and/or amount of secreted protein acidic and rich in cysteine (SPARC) protein. The invention further provides methods for identifying compounds useful in the above-mentioned methods and compositions.

Abstract: A method and system for streaming media data to a mobile client device. Using information such as the previous locations of the mobile client device, a prediction is made of a future location of the client device. A server servicing the predicted location, such as the server closest to the predicted location, is identified. This server is informed of the impending arrival of the mobile device into the area serviced by the server. The server can thus obtain ahead of time the media stream needed for the client, so that the data are available to the client without disruption when the client moves to the predicted location. To account for uncertainty in the prediction, the data can also be directed to other servers that can service the predicted location.

Abstract: A method for performing a soft-handoff in a mobile streaming media system, and a method for performing a hard-handoff in a mobile streaming media system are is disclosed. In the soft-handoff embodiment, the present invention detects that a channel quality between a mobile client and a first base station remains above a drop threshold and that a channel quality between the mobile client and a second base station increases from below to above an add threshold. The present embodiment then sends a first multiple description bitstream from the first base station to the mobile client and sends a complementary second multiple description bitstream from the second base station to the mobile client. This method thereby provides improved utilization of wireless bandwidth during soft-handoffs, in contrast to conventional systems where the same bitstream is transmitted from each base station.

Abstract: A method for handing off to a second server, in either a fixed or mobile streaming media system, a multiple description streaming session between a first server and either a fixed or mobile client. In one embodiment, the present invention recites selecting a second server to receive a handoff of a multiple description streaming media session between the first server and the client. In this embodiment, the multiple description streaming media session is comprised of a first multiple description bitstream and a second multiple description bitstream. The present embodiment further recites receiving at the second server, the second multiple description bitstream for streaming to the client. This embodiment further recites sending the second multiple description bitstream from the second server to the client.

Abstract: A method for assigning servers to provide multiple description bitstreams to a mobile client (in a mobile client environment) or to a fixed client (in a fixed client environment). In one embodiment, the present invention, upon receiving a request from a mobile client to have media data streamed thereto, analyzes a plurality of servers to determine a first candidate server for providing a first multiple description bitstream to the base station along a first path. The present method also determines a second candidate server for providing a second multiple description bitstream to the base station along a second path. The present method then sends a request to the first candidate server to provide the first multiple description bitstream to a mobile client through a base station along the first path, and also sends a request to the second candidate server to provide the second multiple description bitstream to the mobile client through the same base station along a second path.

Abstract: A method and system for streaming media data to a fixed client and/or a mobile client. In one method embodiment, the present invention recites encoding media data to be streamed to a client into a first multiple description bitstream and into a second multiple description bitstream. The present method then determines the appropriate plurality of servers from a network of servers onto which the first and second multiple description bitstreams should be distributed. The present embodiment then recites distributing the first and second multiple description bitstreams to the appropriate plurality of servers positioned at intermediate nodes throughout a network such that a client is provided with access to the media data via a plurality of transmission paths. The present method is also well suited to redistribution of multiple description bitstreams to servers based upon time-varying demand, client movement, and the like.

Abstract: A method and system for streaming media data to a mobile client device. Using information such as the previous locations of the mobile client device, a prediction is made of a future location of the client device. A server servicing the predicted location, such as the server closest to the predicted location, is identified. This server is informed of the impending arrival of the mobile device into the area serviced by the server. The server can thus obtain ahead of time the media stream needed for the client, so that the data are available to the client without disruption when the client moves to the predicted location. To account for uncertainty in the prediction, the data can also be directed to other servers that can service the predicted location.

Abstract: A method for assigning servers to provide multiple description bitstreams to a mobile client (in a mobile client environment) or to a fixed client (in a fixed client environment). In one embodiment, the present invention, upon receiving a request from a mobile client to have media data streamed thereto, analyzes a plurality of servers to determine a first candidate server for providing a first multiple description bitstream to the base station along a first path. The present method also determines a second candidate server for providing a second multiple description bitstream to the base station along a second path. The present method then sends a request to the first candidate server to provide the first multiple description bitstream to a mobile client through a base station along the first path, and also sends a request to the second candidate server to provide the second multiple description bitstream to the mobile client through the same base station along a second path.