Abstract: Methods are provided for determining properties of an anisotropic formation (including both fast and slow formations) surrounding a borehole. A logging-while-drilling tool is provided that is moveable through the borehole. The logging-while drilling tool has at least one dipole acoustic source spaced from an array of receivers. During movement of the logging-while-drilling tool, the at least one dipole acoustic source is operated to excite a time-varying pressure field in the anisotropic formation surrounding the borehole. The array of receivers is used to measure waveforms arising from the time-varying pressure field in the anisotropic formation surrounding the borehole. The waveforms are processed to determine a parameter value that represents shear directionality of the anisotropic formation surrounding the borehole.

Abstract: The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., an lung cancer).

Abstract: Methods and systems are provided that identify relatively large anisotropic horizontal stresses in a formation based on (i) azimuthal variations in the compressional and shear slownesses or velocities of the formation measured from ultrasonic data acquired by at least one acoustic logging tool as well as (ii) cross-dipole dispersions of the formation measured from sonic data acquired by the at least one acoustic logging tool. In addition, the azimuthal variations in the compressional and shear slownesses or velocities of the formation and dipole flexural dispersions of the formation can be jointly inverted to obtain the elastic properties of the rock of the formation in terms of linear and nonlinear constants and the magnitude of maximum horizontal stress of the formation. A workflow for estimating the magnitude of the maximum horizontal stress can employ estimates of certain formation properties, such as overburden stress, magnitude of minimum horizontal stress, and pore pressure.

Abstract: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: A polymer comprising at least one unit of the formula (1) wherein T1 is a carbon atom or a nitrogen atom, T2 is a carbon atom if T1 is a nitrogen atom, or is a nitrogen atom if T1 is a carbon atom, r is 1, 2, 3 or 4, s is 1, 2, 3, or 4, M1 is preferably selected from the group consisting of M2 is preferably The polymers are prepared by reacting monomers (1a) with monomers (2a) H2N-[-M1-]r-NH2 (1a) OHC-[-M2-]s-CHO (2a) or the step of reacting monomers (1b) with monomers (2b) OHC-[-M1-]r-CHO (1b) H2N-[-M2-]s-NH2 (2b).

Abstract: Methods and systems are provided for determining cement quality in an outer annulus of a multi-string cased wellbore having an inner annulus of mud. Data from a sonic logging tool is processed to obtain a slowness dispersion. The slowness dispersion is compared to a plurality of model slowness dispersions generated for a plurality of different values for cement quality in the outer annulus. The cement quality in the outer annulus is determined based on the comparison.

Abstract: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFC). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: Methods are provided for identifying a cementation status of a multi-string cased wellbore utilizing sonic tools with monopole and/or dipole transmitters and with an array of sonic receivers axially displaced from the transmitter(s). The sonic tool is used to record waveforms. The waveforms are then processed to generate slowness and/or attenuation dispersions. The slowness and/or attenuation dispersions are projected onto a slowness and/or attenuation axis, and the results are compared to a data set of projected slowness and/or attenuation dispersions representing a plurality of different multi-string cased wellbore cement status scenarios in order to select the scenario most closely associated with the results. The presence or lack of eccentering of a casing is similarly obtained where the data set includes projected dispersions representing properly centered and ec-centered casings.

Abstract: In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of CD74 with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The CD74-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: Methods are disclosed for detecting fluid in at least one annulus around at least one casing installed in a borehole traversing a formation utilizing a sonic tool. The sonic tool is activated in the borehole and the received sonic waveforms are processed to obtain a dispersion plot. A reference dispersion plot is generated using a model of the borehole where the casing is well-bonded by cement. The obtained and reference dispersion plots are compared. An indication of fluid and in some cases, the specific radial location thereof is obtained based on the signature of the obtained plot as opposed to the reference plot. The methods are effective in doubly-cased boreholes using monopole and/or dipole sources.

Abstract: In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of CD74 with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The CD74-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: Methods and systems are provided that identify relatively large anisotropic horizontal stresses in a formation based on (i) azimuthal variations in the compressional and shear slownesses or velocities of the formation measured from ultrasonic data acquired by at least one acoustic logging tool as well as (ii) cross-dipole dispersions of the formation measured from sonic data acquired by the at least one acoustic logging tool. In addition, the azimuthal variations in the compressional and shear slownesses or velocities of the formation and dipole flexural dispersions of the formation can be jointly inverted to obtain the elastic properties of the rock of the formation in terms of linear and nonlinear constants and the magnitude of maximum horizontal stress of the formation. A workflow for estimating the magnitude of the maximum horizontal stress can employ estimates of certain formation properties, such as overburden stress, magnitude of minimum horizontal stress, and pore pressure.

Abstract: A method for torsional wave logging in a borehole of a subterranean formation. The method includes obtaining a torsional wave measurement of the borehole, wherein the torsional wave measurement represents characteristics of a torsional wave propagating within a cylindrical layered structure associated with the borehole, wherein the cylindrical layered structure comprises the subterranean formation and a completion of the borehole, analyzing, by a computer processor, the torsional wave measurement to generate a quality measure of the completion, and displaying the quality measure of the completion.

Abstract: Provided is a process for preparing a composition comprising semiconducting single-walled carbon nanotubes, a semiconducting polymer and solvent A (composition A), which process comprises the step of separating composition A from a composition comprising semiconducting and metallic single-walled carbon nanotubes, the semiconducting polymer and solvent B (composition B), wherein the semiconducting polymer has a band gap in the range of 0.5 to 1.8 eV and solvent A and B comprise an aromatic or a heteroaromatic solvent, composition A itself, a process for forming an electronic device, which process comprises the step of forming a layer by applying composition A to a precursor of the electronic device, as well as the electronic device obtainable by this process.

Abstract: The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g.

Abstract: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFC). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: Methods are provided for determining properties of an anisotropic formation (including both fast and slow formations) surrounding a borehole. A logging-while-drilling tool is provided that is moveable through the borehole. The logging-while drilling tool has at least one dipole acoustic source spaced from an array of receivers. During movement of the logging-while-drilling tool, the at least one dipole acoustic source is operated to excite a time-varying pressure field in the anisotropic formation surrounding the borehole. The array of receivers is used to measure waveforms arising from the time-varying pressure field in the anisotropic formation surrounding the borehole. The waveforms are processed to determine a parameter value that represents shear directionality of the anisotropic formation surrounding the borehole.

Abstract: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: A polymer comprising at least one unit of the formula (1) wherein T1 is a carbon atom or a nitrogen atom, T2 is a carbon atom if T1 is a nitrogen atom, or is a nitrogen atom if T1 is a carbon atom, r is 1, 2, 3 or 4, s is 1, 2, 3, or 4, M1 is preferably selected from the group consisting of M2 is preferably The polymers are prepared by reacting monomers (1a) with monomers (2a) H2N-[-M1-]r-NH2 (1a) OHC-[-M2-]s-CHO (2a) or the step of reacting monomers (1b) with monomers (2b) OHC-[-M1-]r-CHO (1b) H2N-[-M2-]s-NH2 (2b).

Abstract: Apparatus and method for characterizing a barrier installed in a borehole traversing a formation including locating an acoustic tool with a receiver and a transmitter at a location in the borehole, activating the acoustic tool to form acoustic waveforms, wherein the receiver records the acoustic waveforms, and processing the waveforms to identify barrier parameters as a function of azimuth and depth along the borehole, wherein the waveforms comprise at least two of sonic signals, ultrasonic pulse-echo signals, and ultrasonic pitch-catch signals.