Abstract: Provided are a genetically modified cell line producing a recombinant glycoprotein having a mannose-terminated N-glycan and a method for producing the recombinant glycoprotein or a method for generating the cell, clone or cell line. The cell line comprises an insertion of less than 600 bp in the coding region of a chromosomal sequence encoding MGAT1.

Abstract: A lacosamide pharmaceutical composition as well as a preparation method and application thereof are provided. According to the lacosamide pharmaceutical composition, lacosamide or a pharmaceutically acceptable salt thereof can be dissolved out at the same time, wherein the dissolution rate of the lacosamide pharmaceutical composition is not more than 40% within 1 hour, the dissolution rate of the lacosamide pharmaceutical composition is 20-70% within 6 hours, and the dissolution rate of the lacosamide pharmaceutical composition is not less than 65% within 24 hours. The lacosamide pharmaceutical composition has good slow release performance, the tablet size can be rapidly expanded in the in-vitro dissolution process, the expanded lacosamide pharmaceutical composition has good rigidity and elasticity and has a remarkable retention effect in the stomach, and the cumulative release rate within 24 hours can reach 80% or above.

Abstract: A method for determining lower radius limit of movable throat of shale is provided, and it includes: performing a low-temperature nitrogen adsorption test on a target shale to obtain first pore radii; performing a high-pressure mercury injection test on the target shale to obtain second pore radii; performing a nuclear magnetic resonance test on the target shale to obtain third pore radii; obtaining a relationship diagram of distribution frequencies and pore radii according to three pore radii; distinguishing, according to the pore radii, relationship diagram data, and performing normalization processing to determining a relationship curve of normalized frequency data and the pore radii; and determining a lower radius limit of movable throat of shale according to relationship curve. A problem of describing characteristics of shale occurrence space with complex pore structures and strong heterogeneity is solved, the method is suitable for determining lower radius limit of movable throat of shale.

Abstract: A method for determining lower radius limit of movable throat of shale is provided, and it includes: performing a low-temperature nitrogen adsorption test on a target shale to obtain first pore radii; performing a high-pressure mercury injection test on the target shale to obtain second pore radii; performing a nuclear magnetic resonance test on the target shale to obtain third pore radii; obtaining a relationship diagram of distribution frequencies and pore radii according to three pore radii; distinguishing, according to the pore radii, relationship diagram data, and performing normalization processing to determining a relationship curve of normalized frequency data and the pore radii; and determining a lower radius limit of movable throat of shale according to relationship curve. A problem of describing characteristics of shale occurrence space with complex pore structures and strong heterogeneity is solved, the method is suitable for determining lower radius limit of movable throat of shale.

Abstract: A leather finishing agent that can enhance the mechanical properties and ultraviolet resistance of leather and a preparation method thereof are disclosed that relate to the field of leather additives. It was prepared by using polyphenol as raw material, hexamethylene tetramine as auxiliary agent, and a protonic acid as solvent, then heating and adding water for hydrolysis and dispersion. The method has the advantages of low production cost, simple process, high preparation efficiency, green production process and environmental protection. The leather finishing agent can be used in the finishing section after leather tanning. After finishing, the mechanical properties of the leather were significantly enhanced, and its UV resistance was also significantly improved.

Abstract: A divided-pulse laser regeneration amplification apparatus includes: a signal light coupling component including a first half-wave plate, a first polarization beam splitter, a first Faraday rotator and a second half-wave plate placed in sequence; and a divided-pulse laser regeneration amplification component including a second polarization beam splitter and a third reflector, the second polarization beam splitter is adjacent to the second half-wave plate and is in a same column as the third reflector and the second half-wave plate; a first quarter-wave plate, a Pockels cell and a first reflector are successively arranged on a first side of the second polarization beam splitter, and a third half-wave plate, a first pulse polarization separation component and a first non-linear pulse amplification component are successively arranged on a second side of the second polarization beam splitter.

Abstract: The present disclosure relates to a leather coating composition comprising or consisting of a hydrosilylation curable silicone elastomer composition designed to be used as a topcoat for a synthetic leather material, particularly a silicone-based synthetic leather composite material. A silicone coating as a topcoat for a synthetic leather material which is the cured product of the composition, methods of making the topcoat, synthetic leather material utilizing same and uses of the synthetic leather material products are also disclosed. The topcoat is designed to provide a highly crosslinked silicone matrix containing silicon-free organic micro-particles to minimize or at least decrease change in gloss after abrasion.

Abstract: Provided is a chimeric antigen receptor, comprising an antigen binding region, a transmembrane domain and an intracellular signaling region. The antigen binding region comprises an antibody specifically targeting CD7, and the intracellular signaling region consists of a co-stimulatory domain, a primary signal transduction domain, and a ?C chain or intracellular region thereof. Also provided are an engineered immune cell comprising the chimeric antigen receptor and a pharmaceutical composition thereof, and use of the engineered immune cell/pharmaceutical composition for treating cancers.

Abstract: Provided are use of a rare earth amino acid complex, a polylactic acid composition and a preparation method thereof. The rare earth amino acid complex is formed by complexing a rare earth metal ion with an amino acid; a rare earth element corresponding to the rare earth metal ion is one or more selected from the group consisting of lanthanum, cerium and samarium; and the amino acid is at least one selected from the group consisting of proline, L-phenylalanine, tyrosine and tryptophan.

Abstract: Provided are an ROR1-targeting antibody, and a multispecific antibody, a chimeric antigen receptor, an antibody conjugate, a pharmaceutical composition and a kit which comprise same, and the use thereof in the diagnosis/treatment/prevention of diseases associated with ROR1 expression.

Abstract: Provided are an NKG2A-targeting antibody, and a multispecific antibody, a chimeric receptor, an antibody conjugate, a pharmaceutical composition and a kit which comprise same, and the use thereof in the diagnosis/treatment/prevention of diseases associated with NKG2A expression.

Abstract: An application of collagen peptide in the preparation of an allergen preparation auxiliary material. For an allergen preparation, the auxiliary material thereof does not contain biological macromolecules, but contains the collagen peptide, avoiding the risk of potential allergies caused by the introduction of an inactive substance protein. The allergen preparation containing no biological macromolecule auxiliary materials can be stored stably for three years at room temperature. For allergic patients, the allergen preparation is a highly effective, stable and safe drug.

Abstract: A growth-promoting bacterial agent capable of improving content of soybean oil, preparation method, and use thereof are provided. The growth-promoting bacterial agent is fermented by a DW1 strain, the classification name of the DW1 strain is Bacillus sp., the DW1 strain is deposited in the China Center for Type Culture Collection on Jul. 16, 2021, and the deposit number is CCTCC NO: M 2021889. The growth-promoting bacterial agent of the present disclosure has the ability to dissolve insoluble phosphorus and insoluble potassium and can increase content of readily available phosphorus and readily available potassium in the soil, which has an obvious promoting effect on the growth of soybean and improves soybean yield. The growth-promoting bacterial agent of the present disclosure promotes bacteria and can significantly improve the content of soybean oil. At the same time, it has an affinity of soybean agglutinin and can agglutinate with the soybean agglutinin.

Abstract: A growth-promoting bacterial agent capable of improving content of soybean oil, preparation method, and use thereof are provided. The growth-promoting bacterial agent is fermented by a DW1 strain, the classification name of the DW1 strain is Bacillus sp., the DW1 strain is deposited in the China Center for Type Culture Collection on Jul. 16, 2021, and the deposit number is CCTCC NO: M 2021889. The growth-promoting bacterial agent of the present disclosure has the ability to dissolve insoluble phosphorus and insoluble potassium and can increase content of readily available phosphorus and readily available potassium in the soil, which has an obvious promoting effect on the growth of soybean and improves soybean yield. The growth-promoting bacterial agent of the present disclosure promotes bacteria and can significantly improve the content of soybean oil. At the same time, it has an affinity of soybean agglutinin and can agglutinate with the soybean agglutinin.

Abstract: The present disclosure provides a suspension system with damping and buffering properties, comprising a suspension assembly, a wheel train assembly and a track assembly, the suspension assembly comprises a suspension lateral plate, an approach plate, a first elastic element, a tensioning assembly, a second elastic element, an oscillating arm plate and a damping element; the wheel train assembly comprises a first approach wheel, a second approach wheel, a first load-bearing wheel, a second load-bearing wheel, a track supporting wheel and an actuation wheel. A high stability of a mobile platform moving through obstacles can be realized by assembling the approach plate, the first elastic plate and the damping element into a loading and shock absorbing module in the present disclosure.

Abstract: The present disclosure provides a suspension system with damping and buffering property, comprising a suspension assembly, a wheel train assembly and a track assembly, the suspension assembly comprises a suspension lateral plate, an approach plate, a first elastic element, a tensioning assembly, a second elastic element, an oscillating arm plate and a damping element; the wheel train assembly comprises a first approach wheel, a second approach wheel, a first load-bearing wheel, a second load-bearing wheel, a track supporting wheel and an actuation wheel. A high stability of a mobile platform moving through obstacles can be realized by assembling the approach plate, the first elastic plate and the damping element into a loading and shock absorbing module in the present disclosure.

Abstract: The present invention discloses a high-load explosion-proof driving device, including a servo motor, a reduction box, and a power take-off assembly. The power take-off assembly includes a step sleeve, a coupling, a wheel support sleeve, and a driving wheel. The step sleeve is connected to a robot body, the coupling is disposed through the step sleeve, and a bearing structure and a sealing structure are provided between the coupling and the step sleeve. The coupling is provided with a driving wheel key and a driving wheel sleeve on the left, the driving wheel key is connected to the driving wheel sleeve, and the driving wheel sleeve is connected to the driving wheel. The present invention has the following advantages: the driving device has a high protection capability, and at the same time, power transmitted from the reduction box is distributed, thereby improving loading capability of a mobile chassis.

Abstract: The present invention discloses a high-load explosion-proof driving device, including a servo motor, a reduction box, and a power take-off assembly. The power take-off assembly includes a step sleeve, a coupling, a wheel support sleeve, and a driving wheel. The step sleeve is connected to a robot body, the coupling is disposed through the step sleeve, and a bearing structure and a sealing structure are provided between the coupling and the step sleeve. The coupling is provided with a driving wheel key and a driving wheel sleeve on the left, the driving wheel key is connected to the driving wheel sleeve, and the driving wheel sleeve is connected to the driving wheel. The present invention has the following advantages: the driving device has a high protection capability, and at the same time, power transmitted from the reduction box is distributed, thereby improving loading capability of a mobile chassis.