Patents by Inventor Tiziana Chiodo
Tiziana Chiodo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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CRYSTALLINE FORMS OF 1-(1,2-DIMETHYLPROPYL)-N-ETHYL-5-METHYL-N-PYRIDAZIN-4-YL-PYRAZOLE-4-CARBOXAMIDE
Publication number: 20220024898Abstract: The present invention relates to a novel crystalline form of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide recently assigned the common name dimpropyridaz. The invention also relates to the use of the crystalline form B for combating invertebrate pests and to formulations for plant protection which contain the crystalline form B of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide. The crystalline form B according to the present invention can be identified by powder X-ray diffractometry on the basis of its powder X-ray diffraction diagram, hereinafter also termed powder X-ray diffraction pattern or PXRD pattern, of the polymorph form B recorded using Cu—K? radiation (1.54178 ?) at 25° C. displays the 3 following reflections, quoted as 2? values: 20.69±0.10°, 24.15±0.10° and 30.52±0.10°.Type: ApplicationFiled: January 10, 2020Publication date: January 27, 2022Inventors: Joachim Gebhardt, Martin Viertelhaus, Tiziana Chiodo, Michael Rack, Eric George Klauber, Wen Xu, Roland Goetz, Florian Vogt, Birgit Gockel, Sebastian Soergel -
Patent number: 10224485Abstract: Provided are a process for preparing a crystalline organic semiconductor material wherein the conditions of crystallization lead to the formation of crystals at the gas liquid interface having advantageous semiconductor properties, the obtained crystalline organic semiconductor material and the use thereof for the production of organic semiconductor devices, in particular organic field effect transistors and organic solar cells.Type: GrantFiled: August 17, 2015Date of Patent: March 5, 2019Assignee: BASF SEInventors: Thomas Weitz, Ilja Vladimirov, Tiziana Chiodo, Thomas Seyfried
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Patent number: 10105355Abstract: The present invention primarily relates to multi-component crystals comprising a compound of formula 1 and a second compound selected from the group consisting of co-crystal formers and solvents. The invention is further related to pharmaceutical compositions comprising such multi-component crystals. Furthermore, the invention relates to processes for preparing said multi-component crystals. The invention also relates to several aspects of using said multi-component crystals or pharmaceutical compositions to treat a disease.Type: GrantFiled: August 3, 2015Date of Patent: October 23, 2018Assignee: BASF SEInventors: Martin Viertelhaus, Tiziana Chiodo, Beate Salvador, Marcus Vossen, Andreas Hafner, Tobias Hintermann, Walter Weishaar, Rolf Hellmann
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Patent number: 10053436Abstract: The present invention relates to a process for the preparation of oxirane compounds of formula II from keto compounds III using dimethyl sulfide (CH3)2S and dimethylsulfate (CH3)2SO4, forming the reagent IV, trimethylsulfonium methylsulfate [(CH3)3S+ CH3SO4?], in aqueous solution in the presence of potassium hydroxide (KOH).Type: GrantFiled: June 26, 2015Date of Patent: August 21, 2018Assignee: BASF Agro B.V.Inventors: Joachim Gebhardt, Manfred Ehresmann, Tiziana Chiodo, Martin Viertelhaus, Roland Goetz
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Publication number: 20180230140Abstract: The present invention primarily relates to multicomponent crystals comprising a compound of formula 1 and a second compound selected from the group consisting of menthol and vanillin. The invention is further related to pharmaceutical compositions comprising such multicomponent crystals. Furthermore, the invention relates to processes for preparing said multicomponent crystals. The invention also relates to several aspects of using said multicomponent crystals or pharmaceutical compositions to treat a disease.Type: ApplicationFiled: June 24, 2015Publication date: August 16, 2018Applicant: BASF SEInventors: Martin VIERTELHAUS, Tiziana CHIODO, Beate SALVADOR, Marcus VOSSEN, Andreas HAFNER, Tobias HINTERMANN, Martin SZELAGIEWICZ, Fritz BLATTER
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Patent number: 10045998Abstract: Combinations of (3?)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acid are useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.Type: GrantFiled: December 9, 2014Date of Patent: August 14, 2018Assignee: BASF SEInventors: Tiziana Chiodo, Beate Salvador, Marcus Vossen, Andreas Hafner, Tobias Hintermann, Martin Szelagiewicz, Fritz Blatter, Martin Viertelhaus, Walter Weishaar
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Patent number: 9884857Abstract: The present invention primarily relates to salts of Dasatinib, wherein the salts are in amorphous form. The salts described herein preferably comprise a cation of a compound of formula 1 and an anion of a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin. The invention is further related to pharmaceutical compositions comprising such a salt. Furthermore, the invention relates to processes for preparing said salts. The invention also relates to several aspects of using said salt or pharmaceutical composition to treat a disease.Type: GrantFiled: July 22, 2014Date of Patent: February 6, 2018Assignee: BASF SEInventors: Andreas Hafner, Fritz Blatter, Martin Szelagiewicz, Bernd Siebenhaar, Tiziana Chiodo, Tobias Hintermann, Beate Salvador, Marcus Vossen
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Patent number: 9861104Abstract: The present invention relates to a method for producing an aqueous suspension concentrate formulation and novel suspension concentrate formulations of the compound of formula I. The method comprises: a) providing an aqueous slurry of coarse particles of the compound of the formula I, where the compound of the formula I is at least partially present in its crystalline form B, which, in an X-ray powder diffractogram at 25° C. and Cu-K? radiation, shows at least three, preferably at least four, in particular at least 5 or at least 7 or at least 9 or all of the following reflexes, given as 2? values: 8.0±0.2°, 9.5±0.2°, 10.7±0.2°, 11.0±0.2°, 11.2±0.2°, 11.7±0.2°, 14.2±0.2°, 15.6±0.2°, 16.5±0.2°, 17.7±0.2°, 21.5±0.2°; b) comminuting the coarse particles in the slurry of the compound of formula I, which is at least partially present in its form B, in the presence of the at least one surfactant.Type: GrantFiled: March 11, 2013Date of Patent: January 9, 2018Assignee: BASF SEInventors: Torsten Knieriem, Tiziana Chiodo, Christopher Koradin, Tanja Weber, Walter Weishaar
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Publication number: 20170237005Abstract: Provided are a process for preparing a crystalline organic semiconductor material wherein the conditions of crystallization lead to the formation of crystals at the gas liquid interface having advantageous semiconductor properties, the obtained crystalline organic semiconductor material and the use thereof for the production of organic semiconductor devices, in particular organic field effect transistors and organic solar cells.Type: ApplicationFiled: August 17, 2015Publication date: August 17, 2017Applicant: BASF SEInventors: Thomas WEITZ, llja VLADIMIROV, Tiziana CHIODO, Thomas SEYFRIED
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Publication number: 20170216266Abstract: The present invention primarily relates to multi-component crystals comprising a compound of formula 1 and a second compound selected from the group consisting of co-crystal formers and solvents. The invention is further related to pharmaceutical compositions comprising such multi-component crystals. Furthermore, the invention relates to processes for preparing said multi-component crystals. The invention also relates to several aspects of using said multi-component crystals or pharmaceutical compositions to treat a disease.Type: ApplicationFiled: August 3, 2015Publication date: August 3, 2017Inventors: MARTIN VIERTELHAUS, Tiziana CHIODO, Beate SALVADOR, Marcus VOSSEN, Andreas HAFNER, Tobias HINTERMANN, Walter WEISHAAR, Rolf HELLMANN
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Publication number: 20170166540Abstract: The present invention relates to a process for the preparation of oxirane compounds of formula II from keto compounds III using dimethyl sulfide (CH3)2S and dimethylsulfate (CH3)2SO4, forming the reagent IV, trimethylsulfonium methylsulfate [(CH3)3S+CH3SO4?], in aqueous solution in the presence of potassium hydroxide (KOH).Type: ApplicationFiled: June 26, 2015Publication date: June 15, 2017Applicant: BASF Agro B.V.Inventors: Joachim GEBHARDT, Manfred EHRESMANN, Tiziana CHIODO, Martin VIERTELHAUS, Roland GOETZ
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Patent number: 9567317Abstract: The present invention relates to crystalline materials comprising nilotinib and a carboxylic acid, carboxylic acid ester, carboxylic acid amide or sulfonic acid as a co-crystal former, and to pharmaceutical compositions comprising said materials. The invention also relates to processes for preparing said crystalline materials and to methods of using said crystalline materials to treat a disease condition in which tyrosine kinase inhibition is beneficial.Type: GrantFiled: October 16, 2013Date of Patent: February 14, 2017Assignee: BASF SEInventors: Tiziana Chiodo, Andreas Hafner, Tobias Hintermann, Beate Salvador, Martin Szelagiewicz, Fritz Blatter, Eva Roedel, Marcus Vossen
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Patent number: 9556164Abstract: The present invention primarily relates to molecular crystalline substances, preferably salts of Dasatinib in crystalline form, comprising a compound of formula 1, preferably a cation of a compound of formula 1, and a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin, preferably an anion thereof. The invention is further related to pharmaceutical compositions comprising such a substance. Furthermore, the invention relates to processes for preparing said substances. The invention also relates to several aspects of using said substances or pharmaceutical compositions to treat a disease.Type: GrantFiled: July 22, 2014Date of Patent: January 31, 2017Assignee: BASF SEInventors: Andreas Hafner, Fritz Blatter, Martin Szelagiewicz, Bernd Siebenhaar, Tiziana Chiodo, Tobias Hintermann, Beate Salvador, Marcus Vossen
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Publication number: 20160303143Abstract: Combinations of (3?)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.Type: ApplicationFiled: December 9, 2014Publication date: October 20, 2016Applicant: BASF SEInventors: Tiziana CHIODO, Beate SALVADOR, Marcus VOSSEN, Andreas HAFNER, Tobias HINTERMANN, Martin SZELAGIEWICZ, Fritz BLATTER, Martin VIERTELHAUS, Walter WEISHAAR
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Publication number: 20160168143Abstract: The present invention primarily relates to molecular crystalline substances, preferably salts of Dasatinib in crystalline form, comprising a compound of formula 1, preferably a cation of a compound of formula 1, and a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin, preferably an anion thereof. The Invention is further related to pharmaceutical compositions comprising such a substance. Furthermore, the Invention relates to processes for preparing said substances. The invention also relates to several aspects of using said substances or pharmaceutical compositions to treat a disease.Type: ApplicationFiled: July 22, 2014Publication date: June 16, 2016Inventors: Andreas HAFNER, Fritz BLATTER, Martin SZELAGIEWICZ, Bernd SIEBENHAAR, Tiziana CHIODO, Tobias HINTERMANN, Beate SALVADOR, Marcus VOSSEN
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Publication number: 20160168142Abstract: The present invention primarily relates to salts of Dasatinib, wherein the salts are in amorphous form. The salts described herein preferably comprise a cation of a compound of formula 1 and an anion of a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin. The invention is further related to pharmaceutical compositions comprising such a salt. Furthermore, the invention relates to processes for preparing said salts. The invention also relates to several aspects of using said salt or pharmaceutical composition to treat a disease.Type: ApplicationFiled: July 22, 2014Publication date: June 16, 2016Inventors: Andreas HAFNER, Fritz BLATTER, Martin SZELAGIEWICZ, Bernd SIEBENHAAR, Tiziana CHIODO, Tobias HINTERMANN, Beate SALVADOR, Marcus VOSSER
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Patent number: 9353095Abstract: The present invention relates to a novel crystalline form A of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione. The invention also relates to a process for the production of this crystalline form and formulations for plant protection which contains the novel crystalline form of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione.Type: GrantFiled: May 15, 2013Date of Patent: May 31, 2016Assignee: BASF SEInventors: Robert Reinhard, Tiziana Chiodo, Bernd Wolf, Stefan Scherer, Matthias Bratz, Matthias Witschel, Trevor William Newton, Thomas Seitz
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Patent number: 9340536Abstract: Provided are a multicomponent crystalline system (co-crystal), use thereof, as well as a process for obtaining the same. The said multicomponent crystalline system (co-crystal) comprises Dasatinib and a second compound selected from methyM-hydrobenzoate, nicotinamide, ethyl gallate, methyl gallate, propyl gallate, ethyl maltol, vanillin, menthol, or (1R,2S,5R)-(?)-menthol.Type: GrantFiled: June 13, 2013Date of Patent: May 17, 2016Assignee: BASF SEInventors: Tiziana Chiodo, Andreas Hafner, Tobias Hintermann, Beate Salvador, Martin Szelagiewicz, Fritz Blatter, Bernd Siebenhaar, Marcus Vossen
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Patent number: 9328101Abstract: The present invention relates to a novel crystalline form B of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione The invention also relates to a process for the production of this crystalline form and formulations for plant protection which contains the novel crystalline form of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione.Type: GrantFiled: May 15, 2013Date of Patent: May 3, 2016Assignee: BASF SEInventors: Robert Reinhard, Tiziana Chiodo, Bernd Wolf, Stefan Scherer, Matthias Bratz, Matthias Witschel, Trevor William Newton, Thomas Seitz
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Patent number: 9290452Abstract: The present invention refers to a multicomponent crystalline system (co-crystal) comprising a compound of formula (1) (4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid; INN: Deferasirox) formula (1) and a compound of formula (2) (Isonicotinamide; pyridine-4-carboxamide) formula (2), as well as to a process for obtaining the same.Type: GrantFiled: August 5, 2013Date of Patent: March 22, 2016Assignee: BASF SEInventors: Andreas Hafner, Fritz Blatter, Eva Roedel, Martin Szelagiewicz, Tiziana Chiodo, Tobias Hintermann, Beate Salvador, Marcus Vossen