Abstract: The present invention relates to methods for detecting a malignant tumor in an individual by means of determining the Vimentin variant 3 (Vim3) level in the individual's blood serum S and/or the accumulation of Vim3 polypeptide in cell nuclei. Furthermore, the present invention refers to an antineoplastic agent for use in a method for treating an individual bearing a malignant tumor, wherein said antineoplastic agent is a Vim3 inhibitor and/or wherein the malignant tumor is endothelin B receptor negative.

Abstract: A pharmaceutical composition as a solid oral dosage form is described, comprising: i) a combination of two pharmacological active principles, dexketoprofen salt with an organic or inorganic base and tramadol salt with an organic or inorganic acid, wherein: the organic or inorganic base is selected in the group: trometamol, trimethylamine, dimethylamine, ethylamine, triethylamine, diethylamine, L-lysine, L-arginine, diethanolamine, sodium hydroxide, calcium hydroxide the organic or inorganic acid is selected in the group: hydrochloric, hydrobromic, phosphoric, sulfuric, methanesulfonic, benzenesulfonic, toluenesulfonic, acetic, propionic, malic, maleic, succinic, citric, L-tartaric, lactic, malonic, aspartic, glutamic; ii) microcrystalline cellulose as a filler; iii) a binder selected in the group: maize starch, pre-gelatinized maize starch, hypromellose or their mixtures; iv) pharmaceutically acceptable excipients.

Abstract: The exemplary illustrations generally include a method for controlling and regulating an internal combustion engine-generator system 1000 with a plurality of internal combustion engine-generator units 400 generating electric power which can be connected to a distribution grid and load consumers 200 consuming electric power, with a unit 400 comprising an internal combustion engine 401, 402, 404-408 with variable engine speeds and a generator 421-428, characterized in the steps: determining a given operating state Z* of the internal combustion engine 401, 402, 404-408 of at least one internal combustion engine-generator unit 400; deducting a range of operating states ZB* describing an electric load override Ladm depending on the given operating state Z* for the internal combustion engine of at least one internal combustion engine-generator unit 400, with the determination of the given operating state Z* and the deduction of the range of operating range ZB* occurring based on the calculation model 504 for the in

Abstract: A pharmaceutical composition as a solid oral dosage form is described, comprising: i) a combination of two pharmacological active principles, dexketoprofen salt with an organic or inorganic base and tramadol salt with an organic or inorganic acid, wherein: the organic or inorganic base is selected in the group: trometamol, trimethylamine, dimethylamine, ethylamine, triethylamine, diethylamine, L-lysine, L-arginine, diethanolamine, sodium hydroxide, calcium hydroxide the organic or inorganic acid is selected in the group: hydrochloric, hydrobromic, phosphoric, sulfuric, methanesulfonic, benzenesulfonic, toluenesulfonic, acetic, propionic, malic, maleic, succinic, citric, L-tartaric, lactic, malonic, aspartic, glutamic; ii) microcrystalline cellulose as a filler; iii) a binder selected in the group: maize starch, pre-gelatinised maize starch, hypromellose or their mixtures; iv) pharmaceutically acceptable excipients.

Abstract: The exemplary illustrations generally include a method for controlling and regulating an internal combustion engine-generator system 1000 with a plurality of internal combustion engine-generator units 400 generating electric power which can be connected to a distribution grid and load consumers 200 consuming electric power, with a unit 400 comprising an internal combustion engine 401, 402, 404-408 with variable engine speeds and a generator 421-428, characterized in the steps: determining a given operating state Z* of the internal combustion engine 401, 402, 404-408 of at least one internal combustion engine-generator unit 400; deducting a range of operating states ZB* describing an electric load override Ladm depending on the given operating state Z* for the internal combustion engine of at least one internal combustion engine-generator unit 400, with the determination of the given operating state Z* and the deduction of the range of operating range ZB* occurring based on the calculation model 504 for the in