Abstract: The present disclosure provides a light detection and ranging (LIDAR) system, which comprises: a distance measuring unit configured to emit a plurality of first pulses towards an object located in a field of view (FOV), wherein the object is associated with one or more markers; and a detector configured to receive at least one second pulse from the one or more markers of the object, wherein each of the at least one second pulse indicates object information identifying the object.

Abstract: The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.

Abstract: The present invention provides a vibrating membrane nebulizer with an aerosol generator comprising a vibrator and a membrane, a reservoir for liquid to be aerosolized, a channel and an optical sensor for detecting the presence of aerosol in the channel. The device determines whether aerosol is present in the channel on the basis of the output signal from the optical sensor, in order to detect when the reservoir becomes empty, and stops vibration of the membrane if it determines that no aerosol is present. A method for operating the device is also provided.

Abstract: The present invention provides an inhalation device which has two pumps, one providing a nebulizer flow and the other providing a support flow. The nebulizer flow passes through a nebulizing nozzle to generate an aerosol flow from a liquid. The aerosol flow and the support flow are combined to provide a total flow through a mouthpiece to a patient. The device can be configured specifically for pediatric use by removing the support flow pump. The invention also provides a method of providing a flow of aerosol and / or air to a patient using the device, in particular a device which provides a defined volume of air and aerosol as a bolus at a defined flow rate on each inhalation.

Abstract: A method and a climbing device for lowering a climbing rail, i.e. for climbing downwards. The climbing rail, which is placed on a climbing head by means of an upper protrusion, is lowered in that a climbing cylinder is retracted. The climbing cylinder can be spaced from the climbing rail by completely retracting the climbing cylinder at the upper end by means of a distancing device prior to extending the climbing cylinder again. Thus, the climbing cylinder can be extended again without the climbing rail engaging or hooking below the climbing head at the now central protrusion in that the distancing device moves the climbing head around the central protrusion.

Abstract: The present invention provides a single-use, pre-packaged, sealed container (1) for use with a nebulizer device having an aerosol generator comprising a membrane, the container containing a cleaning liquid (3) and being configured to fit onto the nebulizer device, so that the container is held in place on the nebulizer device and the membrane is immersed in the liquid. The invention also provides a strip comprising a plurality of containers (10), wherein each container is detachable from the rest of the strip; a pack comprising a multi-day supply of a drug and containers; and a method for cleaning the membrane of a nebulizer device using the container.

Abstract: The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.

Abstract: The present invention provides a refillable container (1) for use with a nebulizer device having an aerosol generator comprising a transducer body and a membrane having pores, the container having an opening being fillable with a cleaning liquid (3), wherein the opening is sized and shaped to fit onto the transducer body, so that the container is held in place on the nebulizer device and the membrane is immersed in the liquid inside the container. The invention also provides a pack comprising a multi-day supply of a drug, one or more cleaning liquids and one or more containers; and a method for cleaning the membrane of a nebulizer device using the container.

Abstract: The invention relates to a climbing system (100, 110), in particular a self-climbing formwork system, comprising at least one climbing rail (10) which is guided on at least two climbing shoes (38), wherein the climbing shoes (38) can be fastened on and/or in a cured concreting section (50), and wherein the climbing shoes (30) are designed to guide the climbing rail (10) and/or to hold it at least with respect to a climbing direction (K), and an actuator (16). The invention is characterized in that the at least one climbing rail (10) has at least a first and a second rail part (12, 14), wherein the first and the second rail part (12, 14) are arranged one behind the other as viewed in the climbing direction (K), in that the first and the second rail part (12, 14) can each be guided and held by means of one of the climbing shoes (38), and in that the actuator (16) is designed to selectively increase or reduce the distance (d) between the first and the second rail part (12, 14) along the climbing direction.

Abstract: The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.

Abstract: The invention relates to a dosing system for an inhalation device which is capable of aliquoting a precise and accurately metered volume from a larger pre-defined fill volume. The dosing system comprises a filling chamber for receiving a liquid to be aerosolized, the filling chamber having a lateral wall, an inlet opening and an outlet opening with a closing means (11) for closing the outlet opening. The dosing system further comprises an overflow chamber surrounding the inlet opening of the filling chamber and a plunger which can be inserted, at least partially, into the filling chamber, and which sealingly contacts the lateral wall such as to displace liquid from said filling chamber upon insertion, and push a metered volume of the liquid out from the filling chamber through the outlet opening and feed it to the nebulizing means of the inhalation device.

Abstract: The invention provides a dosing system for an inhalation device, comprising a filling chamber (10); a reservoir chamber (31) which supplies liquid (3) to an aerosol generator (301); and a plunger (20) which includes an overflow chamber (25) and which is pivotable about a hinge (50). The filling chamber has an inner wall (12) which is higher on the side adjacent to the hinge than on the opposite side. When the filling chamber is filled with liquid and the plunger is pivoted into the filling chamber, part of the liquid is displaced over the lower side (17) of the inner wall into the reservoir chamber and some or all of the remaining liquid is displaced into the overflow chamber. The invention also provides an inhalation device comprising the dosing system and a method for dosing liquid to the inhalation device.

Abstract: Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.

Abstract: The invention relates to a method and a climbing device (10) for lowering a climbing rail, i.e. for climbing downwards. In the method, the climbing rail, which is placed on a climbing head (18) by means of an upper protrusion, is lowered in that a climbing cylinder (20) is retracted. In particular, the climbing cylinder can be spaced from the climbing rail by completely retracting the climbing cylinder (20) at the upper end by means of a distancing device (34) prior to extending the climbing cylinder (20) again. Thus, the climbing cylinder (20) can be extended again without the climbing rail engaging or hooking below the climbing head (18) at the now central protrusion in that the distancing device (34) moves the climbing head (18) around the central protrusion.

Abstract: The present invention provides a single-use, pre-packaged, sealed container (1) for use with a nebulizer device having an aerosol generator comprising a membrane, the container containing a cleaning liquid (3) and being configured to fit onto the nebulizer device, so that the container is held in place on the nebulizer device and the membrane is immersed in the liquid. The invention also provides a strip comprising a plurality of containers (10), wherein each container is detachable from the rest of the strip; a pack comprising a multi-day supply of a drug and containers; and a method for cleaning the membrane of a nebulizer device using the container.

Abstract: An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.

Abstract: The invention provides an inhalation device for enabling a user to inhale at a desired inspiratory flow rate and/or pressure, comprising a feedback system configured to indicate to a user by means of a signal during an inhalation maneuver whether an inhalation parameter, such as the inspiratory flow rate, is within a predefined target range. The signal may be an optical or a non-optical signal, such as a light signal, an acoustic signal, or a tactile signal.

Abstract: Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.

Abstract: An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.