Patents by Inventor Tobias M. Heineck
Tobias M. Heineck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230096475Abstract: A method of analyzing a blood sample from a subject includes loading the blood sample into a single chamber; acquiring, via an imaging system, a stack of serial focal plane images of the blood sample from a plurality of fields of view of the chamber; creating a virtual three dimensional image of the blood sample from selected ones of the stacks of serial focal plane images; and analyzing the virtual three dimensional image to identify blood formed elements within the blood sample. Identifying blood formed elements within the blood sample may include identifying a type and amount of white blood cells, and/or identifying an amount of red blood cells and/or hematocrit, and/or identifying an amount of platelets. Identifying blood formed elements within the blood sample may include determining numbers and percentage by volume in the blood sample of one or more types of white blood cells.Type: ApplicationFiled: March 12, 2021Publication date: March 30, 2023Inventors: Joy Parr Drach, Brendan Smith, Tobias M. Heineck, Stefano Bresolin, Rodolfo R. Rodriguez, Danielle Stewart Noel, Brian Pike, Oleg Kakhovsky, Jasper N. Pollard
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Publication number: 20210270803Abstract: The present invention provides a method of identifying an animal for which antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy is appropriate, comprising: a) collecting a sample from said animal; b) performing a leukocyte differential cell count on said sample; c) comparing said leukocyte differential cell count of (b) with an index of infection; and d) initiating antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy of said animal on the basis of said comparing step.Type: ApplicationFiled: February 12, 2021Publication date: September 2, 2021Inventors: Joy Parr Drach, Mitchell Hockett, Stefano Bresolin, Erik J. Jensen, Tobias M. Heineck, Jasper N. Pollard, Deborah Asion, Rodolfo R. Rodriguez, David A. Calderwood, Norah Gerow Bate, John Richard Sink, Jorge Carlos Correa
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Patent number: 10690900Abstract: A microscope assembly for use in an automated microscope apparatus has a support frame; a cartridge magazine actuator assembly connected to the support frame; a subframe; a plurality of vibration isolators connecting the support frame to the subframe; an XYZ drive connected to the subframe; and an optical stage connected to the subframe. In some embodiments the assembly further includes a cartridge gripper connected to said XYZ drive. In some embodiments, the cartridge magazine actuator assembly includes an input element, an output element, and a transfer assembly interconnecting the input element and the output element, with the transfer assembly configured to linearly advance the output element upon linear depression of the input element.Type: GrantFiled: September 23, 2014Date of Patent: June 23, 2020Assignee: ADVANCED ANIMAL DIAGNOSTICS, INC.Inventors: Rick Sink, Jasper N. Pollard, Demetris Young, Jorge Carlos Correa, David Newcomb, Stefano Bresolin, Tobias M. Heineck, David A. Calderwood
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Patent number: 10620190Abstract: An automated microscope apparatus, comprises an outer housing having an external wall; optionally but preferably an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing; a microscope assembly in said housing, preferably in said first compartment; and a microprocessor in said housing, preferably in said second compartment; and optionally but preferably a heat sink mounted on said housing external wall, preferably adjacent said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.Type: GrantFiled: November 13, 2017Date of Patent: April 14, 2020Assignee: Advanced Animal Diagnostics, Inc.Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jaspar N> Pollard, Rodolfo R. Rodriguez, Demetris Young
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Patent number: 10359614Abstract: An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.Type: GrantFiled: July 2, 2013Date of Patent: July 23, 2019Assignee: Advanced Animal Diagnostics, Inc.Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young
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Patent number: 10222383Abstract: The present invention provides methods and compositions for detecting Mycoplasma exposure in a subject.Type: GrantFiled: January 27, 2017Date of Patent: March 5, 2019Assignee: Advanced Animal Diagnostics, Inc.Inventors: Robert L. Campbell, Melissa E. Langer, Jasper N. Pollard, Robert L. Cheek, Kevin G. Dolan, W. William Stewart, Stefano Bresolin, John Richard Sink, Tobias M. Heineck, Laura A. Black, Nathan F. Pope, Lauren K. Parker, Erik J. Jensen, Jorge Carlos Correa, Reha O. Azizoglu
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Publication number: 20180172676Abstract: An automated microscope apparatus, comprises an outer housing having an external wall; optionally but preferably an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing; a microscope assembly in said housing, preferably in said first compartment; and a microprocessor in said housing, preferably in said second compartment; and optionally but preferably a heat sink mounted on said housing external wall, preferably adjacent said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.Type: ApplicationFiled: November 13, 2017Publication date: June 21, 2018Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jaspar N. Pollard, Rodolfo R. Rodriguez, Demetris Young
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Patent number: 9816982Abstract: An automated microscope apparatus, comprises an outer housing having an external wall; optionally but preferably an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing; a microscope assembly in said housing, preferably in said first compartment; and a microprocessor in said housing, preferably in said second compartment; and optionally but preferably a heat sink mounted on said housing external wall, preferably adjacent said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.Type: GrantFiled: June 27, 2013Date of Patent: November 14, 2017Assignee: Advanced Animal Diagnostics, Inc.Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young
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Patent number: 9797893Abstract: A device for detecting at least one analyte in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid (e.g., milk) therein, wherein said chamber is an elongate chamber having a length axis; (ii) a (stationary or movable) carrier (in some embodiments in the form of an end cap, or connected to an end cap; in other embodiments in the form of an agitator in said elongate chamber).Type: GrantFiled: May 9, 2014Date of Patent: October 24, 2017Assignee: Advanced Animal Diagnostics, Inc.Inventors: Reha O. Azizoglu, Stefano Bresolin, David A. Calderwood, Robert L. Cheek, Joy Parr Drach, John Groelke, Tobias M. Heineck, Mitchell Hockett, David Newcomb, Duane Olsen, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young
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Publication number: 20170276663Abstract: The present invention provides a method of identifying an animal for which antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy is appropriate, comprising: a) collecting a sample from said animal; b) performing a leukocyte differential cell count on said sample; c) comparing said leukocyte differential cell count of (b) with an index of infection; and d) initiating antibiotic treatment, anti-infective treatment, probiotic treatment, immunostimulant treatment, additional monitoring and/or a separate or alternative management strategy of said animal on the basis of said comparing step.Type: ApplicationFiled: March 22, 2017Publication date: September 28, 2017Inventors: Joy Parr Drach, Mitchell Hockett, Stefano Bresolin, Erik J. Jensen, Tobias M. Heineck, Jasper N. Pollard, Deborah Asion, Rodolfo R. Rodriguez, David A. Calderwood, Norah Gerow Bate, John Richard Sink, Jorge Carlos Correa
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Publication number: 20170219604Abstract: The present invention provides methods and compositions for detecting Mycoplasma exposure in a subject.Type: ApplicationFiled: January 27, 2017Publication date: August 3, 2017Inventors: Robert L. Campbell, Melissa E. Langer, Jasper N. Pollard, Robert L. Cheek, Kevin G. Dolan, W. William Stewart, Stefano Bresolin, John Richard Sink, Tobias M. Heineck, Laura A. Black, Nathan F. Pope, Lauren K. Parker, Erik J. Jensen, Jorge Carlos Correa, Reha O. Azizoglu
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Publication number: 20160291308Abstract: A microscope assembly for use in an automated microscope apparatus has a support frame; a cartridge magazine actuator assembly connected to the support frame; a subframe; a plurality of vibration isolators connecting the support frame to the subframe; an XYZ drive connected to the subframe; and an optical stage connected to the subframe. In some embodiments the assembly further includes a cartridge gripper connected to said XYZ drive. In some embodiments, the cartridge magazine actuator assembly includes an input element, an output element, and a transfer assembly interconnecting the input element and the output element, with the transfer assembly configured to linearly advance the output element upon linear depression of the input element.Type: ApplicationFiled: September 23, 2014Publication date: October 6, 2016Inventors: Rick Sink, Jasper N. Pollard, Demetris Young, Jorge Carlos Correa, David Newcomb, Stefano Bresolin, Tobias M. Heineck, David A. Calderwood
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Publication number: 20150037835Abstract: An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.Type: ApplicationFiled: July 3, 2013Publication date: February 5, 2015Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young
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Publication number: 20140363882Abstract: A device for detecting at least one analyte in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid (e.g., milk) therein, wherein said chamber is an elongate chamber having a length axis; (ii) a (stationary or movable) carrier (in some embodiments in the form of an end cap, or connected to an end cap; in other embodiments in the form of an agitator in said elongate chamber).Type: ApplicationFiled: May 9, 2014Publication date: December 11, 2014Inventors: Reha O. Azizoglu, Stefano Bresolin, David A. Calderwood, Robert L. Cheek, Joy Parr Drach, John Groelke, Tobias M. Heineck, Mitchell Hockett, David Newcomb, Duane Olsen, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young
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Publication number: 20140315283Abstract: A sample cartridge (40) for microscopic imaging of a biological sample comprises a body having an end portion (43) and a pair of generally parallel opposing side edge portions (44), a locking edge portion (45) formed on the body; a carrier removably connected to or permanently connected to the body; and at least one anti-analyte antibody coupled to either the carrier or to the chamber (41) side wall portion (e.g., at the surface to be imaged, or supporting the sample to be imaged). An XYZ stage (101) for receiving such a cartridge (40) is also described.Type: ApplicationFiled: May 9, 2013Publication date: October 23, 2014Inventors: David A. Calderwood, Rodolfo Rodriguez, Demetris Young, Jasper N. Pollard, Robert L. Cheek, Duane Olsen, John Groelke, Reha Azizoglu, Mitch Hockett, David Newcomb, Tobias M. Heineck, Joy Parr Drach
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Publication number: 20140233098Abstract: An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.Type: ApplicationFiled: July 2, 2013Publication date: August 21, 2014Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young
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Publication number: 20140186859Abstract: A method of automatically focusing a microscope on a specimen is carried out by capturing an image from each of a plurality of focal planes in or on said specimen, calculating a focus score for each of said images, selecting the focal plane corresponding to the image having the best focus score, and then repositioning said specimen relative to said microscope so that said microscope is focused on said selected focal plane, the method includes a plurality of exogenous targets in or on said specimen, which aids in focusing in the event particular objects of interest, such as cells/pathogens that may or may not be in the sample, are not present, or are present in low numbers. Automated microscopes and microscope cartridges useful in such methods are also described, along with methods of detecting pathogens in biological samples.Type: ApplicationFiled: May 9, 2013Publication date: July 3, 2014Inventors: David A. Calderwood, Rodolfo R. Rodriguez, Tobias M. Heineck, Stefano Bresolin, Chris Paul, Demetris Young, Jasper N. Pollard, David Newcomb, Robert L. Cheek, Reha Azizoglu, Mitch Hockett, Duane Olsen, John Groelke
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Publication number: 20140009596Abstract: An automated microscope apparatus, comprises an outer housing having an external wall; optionally but preferably an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing; a microscope assembly in said housing, preferably in said first compartment; and a microprocessor in said housing, preferably in said second compartment; and optionally but preferably a heat sink mounted on said housing external wall, preferably adjacent said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.Type: ApplicationFiled: June 27, 2013Publication date: January 9, 2014Inventors: Stefano Bresolin, David A. Calderwood, Tobias M. Heineck, David Newcomb, Chris Paul, Jasper N. Pollard, Rodolfo R. Rodriguez, Demetris Young