Patents by Inventor Tobias Metzenthin

Tobias Metzenthin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Capping of unprotected amino groups during peptide synthesis
    Patent number: 11028123
    Abstract: The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: June 8, 2021
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Bernd Henkel, Tobias Metzenthin, Manfred Gerken, Wolfgang Fiedler
  • CAPPING OF UNPROTECTED AMINO GROUPS DURING PEPTIDE SYNTHESIS
    Publication number: 20190330263
    Abstract: The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).
    Type: Application
    Filed: April 10, 2019
    Publication date: October 31, 2019
    Inventors: Bernd Henkel, Tobias Metzenthin, Manfred Gerken, Wolfgang Fiedler
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20140005392
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: Sanofi
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives
    Patent number: 8546567
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: October 1, 2013
    Assignee: Sanofi
    Inventors: Joachim Graeser, Guenter Billen, Adolf Linkies, Tobias Metzenthin
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20120271051
    Abstract: This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 25, 2012
    Applicant: SANOFI
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives
    Patent number: 8232395
    Abstract: This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 31, 2012
    Assignee: Sanofi
    Inventors: Joachim Graeser, Guenter Billen, Adolf Linkies, Tobias Metzenthin
  • METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES
    Publication number: 20080214813
    Abstract: This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.
    Type: Application
    Filed: December 3, 2007
    Publication date: September 4, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Joachim GRAESER, Guenter BILLEN, Adolf LINKIES, Tobias METZENTHIN
  • Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use
    Patent number: 7009047
    Abstract: The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: March 7, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Javier Manero, Tobias Metzenthin, Rainer Gauler
  • Synthesis of 2-chloromethyl-6-methylbenzoic ester
    Patent number: 6989462
    Abstract: A process is described for preparing compounds of formula (I) where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2 groups may be replaced by —O—. The compounds of the formula (I) are valuable intermediates in the synthesis of PPAR agonists.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: January 24, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Claus-Jürgen Maier, Tobias Metzenthin, Joachim Graeser, Richard Bicker, Javier Manero
  • Synthesis of 2-chloromethyl-6-methylbenzoic ester
    Publication number: 20040192956
    Abstract: A process is described for preparing compounds of formula (I) 1
    Type: Application
    Filed: March 18, 2004
    Publication date: September 30, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Claus-Jurgen Maier, Tobias Metzenthin, Joachim Graeser, Richard Bicker, Javier Manero
  • Crystalline forms of the sodium salt of 5-chloro-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonylpenyl)ethyl)benzamide
    Patent number: 6723751
    Abstract: The present invention relates to crystalline forms of the sodium salt of 5-chloro-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonylphenyl)ethyl)benzamide, processes for their preparation, their use, and pharmaceutical preparations comprising them.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: April 20, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Heinrich Christian Englert, Uwe Gerlach, Harald Schneider, Tobias Metzenthin
  • Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use
    Publication number: 20040010039
    Abstract: The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.
    Type: Application
    Filed: March 17, 2003
    Publication date: January 15, 2004
    Inventors: Javier Manero, Tobias Metzenthin, Rainer Gauler
  • Process for preparing trifluoroacetyl fluoride
    Patent number: 5672748
    Abstract: The invention relates to the preparation of trifluoroacetyl fluoride by reacting trichloroacetyl chloride with anhydrous hydrogen fluoride in the gaseous phase on a catalyst which is obtainable by reacting a water-soluble chromium (III) salt with magnesium hydroxide or magnesium oxide in the presence of water, converting the reaction mixture into a paste, drying the paste and treating it with hydrogen fluoride.
    Type: Grant
    Filed: June 29, 1995
    Date of Patent: September 30, 1997
    Assignee: Solvay
    Inventors: Frank Ebmeyer, Tobias Metzenthin, Gunter Siegemund
  • Process for the preparation of trichloroacetyl chloride
    Patent number: 5659078
    Abstract: The invention relates to a process for the preparation of trichloroacetyl chloride by reaction of acetyl chloride or acetaldehyde or chlorinated derivatives thereof with chlorine in the presence of active charcoal as the catalyst.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: August 19, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Frank Ebmeyer, Tobias Metzenthin, Gunter Siegemund
  • Process for preparing trifluoroethyl sulfur compounds from thiolates and 1-chloro-2,2,2-trifluoroethane
    Patent number: 5534634
    Abstract: Process for preparing trifluoroethyl sulfur compounds from thiolates and 1-chloro-2,2,2-trifluoroethane. The invention relates to the preparation of trifluoroethyl sulfur compounds of the formula RSCH.sub.2 CF.sub.3 by reacting 1-chloro-2,2,2-trifluoroethane CH.sub.2 Cl--CF.sub.3 in a polar aprotic solvent with salts of thiols of the formula RSH, where R can be an alkyl or aryl radical or a heterocyclic radical.
    Type: Grant
    Filed: September 29, 1994
    Date of Patent: July 9, 1996
    Assignee: Hoechst AG
    Inventors: Wolfgang Appel, Frank Ebmeyer, Tobias Metzenthin, Gunter Siegemund