Patents by Inventor Toby Howard Richardson

Toby Howard Richardson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED ENZYMES AND METHODS OF MAKING AND USING
    Publication number: 20230348865
    Abstract: The invention provides an engineered carboxylic acid reductase (CAR) enzyme, a nucleic acid encoding the CAR enzyme, and a non-naturally occurring microbial organism comprising an exogenous nucleic acid encoding the CAR, an engineered transaminase (TA) enzyme, and/or a hexamethylenediamine (HMD) transaminase (TA2) enzyme. The invention provides a non-naturally occurring microbial organism that has a 1,6-hexanediol (HDO) pathway with a HDO pathway enzyme expressed in sufficient amounts to produce 6 aminocaproate semi aldehyde, HDO, or both. The invention further provides a non-naturally occurring microbial organism that has an HMD pathway with a HMD pathway enzyme expressed in sufficient amounts to produce 6-aminocaproate semialdehyde, HMD, or both. The invention additionally provides bioderived HMD, 6-aminocaproate semialdehyde, and/or HDO and methods for producing bioderived HMD, 6-aminocaproate semialdehyde, and/or HDO.
    Type: Application
    Filed: April 23, 2021
    Publication date: November 2, 2023
    Inventors: Amit Mahendra SHAH, Deqiang ZHANG, Joseph Roy WARNER, Benjamin Matthew GRIFFIN, Russell Scott KOMOR, Harish NAGARAJAN, Sankha GHATAK, Toby Howard RICHARDSON
  • Identification of centromere sequences and uses therefor
    Patent number: 9758810
    Abstract: Provided herein are methods for identifying centromeres and centromeres identified by such methods. Centromeres of organisms such as algae, fungi, and protists can be used, for example, for constructing artificial chromosomes and cells containing such artificial chromosomes.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: September 12, 2017
    Assignee: Synthetic Genomics, Inc.
    Inventors: Helge Zieler, Robert Christopher Brown, Toby Howard Richardson, Douglas Gillette Smith
  • DGAT genes comprising pleckstrin homology domains and methods of use for triglyceride production in recombinant microorganisms
    Patent number: 8835149
    Abstract: The present invention provides novel diacylglycerol acyltransferase (DGAT) genes comprising Pleckstrin Homology (PH) domains. The present invention also provides for recombinant cells, such as algae, transformed with acyltransferase genes, such as DGAT, comprising PH domains, and methods of using such recombinant cells to produce increased triglyceride levels.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: September 16, 2014
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Jennifer Coppersmith, Rekha Seshadri, Toby Howard Richardson
  • DGAT GENES COMPRISING PLECKSTRIN HOMOLOGY DOMAINS AND METHODS OF USE FOR TRIGLYCERIDE PRODUCTION IN RECOMBINANT MICROORGANISMS
    Publication number: 20140162329
    Abstract: The present invention provides novel diacylglycerol acyltransferase (DGAT) genes comprising Pleckstrin Homology (PH) domains. The present invention also provides for recombinant cells, such as algae, transformed with acyltransferase genes, such as DGAT, comprising PH domains, and methods of using such recombinant cells to produce increased triglyceride levels.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 12, 2014
    Applicant: ExxonMobil Research and Engineering Company
    Inventors: Jennifer Coppersmith, Rekha Seshadri, Toby Howard Richardson
  • Methods of enhancing biogenic production of methane from hydrocarbon-bearing formations
    Patent number: 8448702
    Abstract: The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: May 28, 2013
    Assignee: Synthetic Genomics, Inc.
    Inventors: Gerardo Vicente Toledo, Toby Howard Richardson, Ulrich Stingl, Eric J. Mathur, J. Craig Venter
  • Methods of identifying stimulants for methane production from hydrocarbon-bearing formations
    Publication number: 20110277991
    Abstract: The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.
    Type: Application
    Filed: July 6, 2011
    Publication date: November 17, 2011
    Applicant: Synthetic Genomics, Inc.
    Inventors: Gerardo Vicente Toledo, Toby Howard Richardson, Ulrich Stingl, Eric J. Mathur, J. Craig Venter
  • Methods of identifying stimulants for biogenic methane production from hydrocarbon-bearing formations
    Patent number: 7977056
    Abstract: The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: July 12, 2011
    Assignee: Synthetic Genomics, Inc.
    Inventors: Gerardo Vicente Toledo, Toby Howard Richardson, Ulrich Stingl, Eric J. Mathur, J. Craig Venter
  • METHODS TO STIMULATE BIOGENIC METHANE PRODUCTION FROM HYDROCARBON-BEARING FORMATIONS
    Publication number: 20100047793
    Abstract: The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.
    Type: Application
    Filed: May 12, 2009
    Publication date: February 25, 2010
    Inventors: Gerardo Vicente TOLEDO, Toby Howard RICHARDSON, Ulrich STINGL, Eric J. MATHUR, J. Craig VENTER
  • IDENTIFICATION OF CENTROMERE SEQUENCES AND USES THEREFOR
    Publication number: 20100041035
    Abstract: Provided herein are methods for identifying centromeres and centromeres identified by such methods. Centromeres of organisms such as algae, fungi, and protists can be used, for example, for constructing artificial chromosomes and cells containing such artificial chromosomes.
    Type: Application
    Filed: April 28, 2009
    Publication date: February 18, 2010
    Inventors: Helge Zieler, Robert Christopher Brown, Toby Howard Richardson, Douglas Gillette Smith