Patents by Inventor Todd Bowser

Todd Bowser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds
    Publication number: 20110092467
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • 7- and 9- carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
    Patent number: 7858600
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: December 28, 2010
    Assignees: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • Substituted Tetracycline Compounds
    Publication number: 20100305072
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
    Type: Application
    Filed: December 21, 2007
    Publication date: December 2, 2010
    Inventors: Oak K. Kim, Mark L. Nelson, Paul Abato, Haregewein Assefa, Joel Bernaiac, Mohamed Y. Ismail, Todd Bowser, Mark Grier, Beena Bhatia, Atul K. Verma, Laura Honeyman, Jingwen Pan
  • PRODRUGS OF 9-AMINOMETHYL TETRACYCLINE COMPOUNDS
    Publication number: 20100249076
    Abstract: The invention pertains to prodrugs of 9-aminomethyl substituted tetracycline compounds, methods of using the compounds, and pharmaceutical compositions containing them.
    Type: Application
    Filed: June 3, 2010
    Publication date: September 30, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Victor Amoo, Haregewein Assefa, Beena Bhatia, Joel Berniac, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Oak K. Kim, Rachid Mechiche, Kwasi Ohemeng, Jingwen Pan
  • TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED METHODS OF TREATMENT
    Publication number: 20100190755
    Abstract: The present invention pertains, at least in part, to substituted tetracycline compounds. The present invention also pertains to methods for treating rheumatoid arthritis in a subject, comprising administering to the subject a tetracycline compound of the invention.
    Type: Application
    Filed: September 21, 2009
    Publication date: July 29, 2010
    Inventors: Paul Abato, Todd Bowser, Paul Higgins, Atul K. Verma, Jie Zhang-Hoover
  • 7,9-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20100160263
    Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: November 12, 2009
    Publication date: June 24, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy Nagavelli, Karen Stepleton, Tad Warchol, Paul Sheahan
  • 9-Aminomethyl Substituted Minocycline Compounds
    Publication number: 20100113400
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 28, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • 7,9-substituted tetracycline compounds
    Patent number: 7696186
    Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: April 13, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy, Karen Stapleton, Tadeusz Warchol, Paul Sheahan
  • Substituted Tetracycline Compounds
    Publication number: 20100022483
    Abstract: The present invention pertains, at least in part, to methods of treating a microorganism-associated infection in a subject comprising administering to said subject an effective amount of a tetracycline compound.
    Type: Application
    Filed: April 14, 2009
    Publication date: January 28, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20090325908
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: January 9, 2009
    Publication date: December 31, 2009
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 7-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20090306022
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 10, 2009
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 7-substituted tetracycline compounds
    Patent number: 7595309
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: September 29, 2009
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Beena Bhatia, David Messersmith, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Darrell J. Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul K. Verma, Tadeusz Warchol, Upul Bandarage
  • 9-aminomethyl substituted minocycline compounds
    Patent number: 7553828
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: June 30, 2009
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20090131401
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: February 12, 2008
    Publication date: May 21, 2009
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia, Todd Bowser, Mark Grier
  • Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
    Publication number: 20090118269
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Application
    Filed: April 14, 2008
    Publication date: May 7, 2009
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • Transcription factor modulating compounds and methods of use thereof
    Patent number: 7405235
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: July 29, 2008
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael N. Alekshun, Brent L. Podlogar, Kwasi Ohemeng, Atul K. Verma, Tadeusz Warchol, Beena Bhatia, Todd Bowser, Mark Grier
  • Amino-methyl substituted tetracycline compounds
    Patent number: 7326696
    Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: February 5, 2008
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Y. Ismail, Oak Kim, Rachid Mechiche, N. Laxma Reddy, Atul K. Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov
  • Amino-methyl substituted tetracycline compounds
    Publication number: 20080015169
    Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
    Type: Application
    Filed: June 5, 2007
    Publication date: January 17, 2008
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Ismail, Oak Kim, Rachid Mechiche, N. Reddy, Atul Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov
  • 10-substituted tetracyclines and methods of use thereof
    Publication number: 20070093455
    Abstract: 10-Substituted tetracycline compounds are described.
    Type: Application
    Filed: July 21, 2006
    Publication date: April 26, 2007
    Inventors: Paul Abato, Haregewein Assefa, Joel Berniac, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman
  • Prodrugs of 9-aminomethyl tetracycline compounds
    Publication number: 20060287283
    Abstract: The invention pertains to prodrugs of 9-aminomethyl substituted tetracycline compounds, methods of using the compounds, and pharmaceutical compositions containing them.
    Type: Application
    Filed: January 12, 2006
    Publication date: December 21, 2006
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Victor Amoo, Haregewein Assefa, Beena Bhatia, Joel Berniac, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Oak Kim, Rachid Mechiche, Kwasi Ohemeng, Jingwen Pan