Patents by Inventor Todd DeZwaan

Todd DeZwaan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic plants with enhanced agronomic traits
    Publication number: 20110004955
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: January 29, 2009
    Publication date: January 6, 2011
    Applicant: Monsanto Technology LLC
    Inventors: Mark Abad, Erin Bell, R. Eric Cerny, Jaishree M. Chittoor-Vijayanath, Molian Deng, Michael D. Edgerton, Karen K. Gabbert, Barry S. Goldman, Brian Hauge, Steve He, Jacqueline E. Heard, Ping Li, Linda Lutfiyya, Bradley McDill, Robert J. Meister, Peter Morrell, Anil Neelam, Marie Petracek, John Pitkin, M. S. Rajani, Maria F. Rodriguez, Thomas Ruff, T. V. Venkatesh, Xiaoyun Wu, Jianmin Zhao, Albert Iandolino, Monica Ravanello, Kraig Brustad, Paul Chomet, Julie Davis, Virginia Ursin, T. Ambika, Shobha Char, Savitha Madappa, Dhanalakshmi Ramachandra, S. Sangeetha, K. R. Vidya, K. Vijayalakshmi, Todd Dezwaan
  • Methods for the identification of inhibitors of cyclic nucleotide phosphodiesterase as antibiotics
    Publication number: 20050233404
    Abstract: The present inventors have discovered that a cyclic nucleotide phosphodiesterase is essential for normal fungal pathogenicity. Specifically, the inhibition of PDE2 gene expression in Magnaportha grisea severely reduces the pathogenicity of the fungus. Thus, PDE2 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit PDE2 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably fungicides.
    Type: Application
    Filed: January 24, 2005
    Publication date: October 20, 2005
    Inventors: Matthew Tanzer, Jeffrey Shuster, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey
  • Methods for the identification of inhibitors of adenylosuccinate synthase as antibiotics
    Publication number: 20050227305
    Abstract: The present inventors have discovered that adenylosuccinate synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of adenylosuccinate synthase gene expression in fungi results in drastically reduced pathogenicity. Thus, adenylosuccinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit adenylosuccinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: January 13, 2005
    Publication date: October 13, 2005
    Inventors: Matthew Tanzer, Jeffrey Shuster, Lisbeth Hamer, Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey, Kiichi Adachi
  • Methods for the identification of inhibitors of histidinol dehydrogenase as antibiotics
    Publication number: 20050227304
    Abstract: The present inventors have discovered that a histidinol dehydrogenase (HIS4) is essential for normal fungal pathogenicity, Specifically, the inhibition of HIS4 gene expression in Magnaportha grisea severely reduces the pathogenicity of the fungus. Thus, HIS4 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit HIS4 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably fungicides.
    Type: Application
    Filed: March 10, 2005
    Publication date: October 13, 2005
    Inventors: Matthew Tanzer, Jeffrey Shuster, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey
  • Methods for the identification of inhibitors of amidophosphoribosyltransferase as antibiotics
    Publication number: 20050221409
    Abstract: The present inventors have discovered that amidophosphoribosyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of amidophosphoribosyltransferase gene expression in fungi results in drastically reduced pathogenicity. Thus, amidophosphoribosyltransferase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit amidophosphoribosyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: October 20, 2004
    Publication date: October 6, 2005
    Inventors: Matthew Tanzer, Jeffrey Shuster, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey
  • Methods for the identification of inhibitors of acetolactate synthase as antibiotics
    Publication number: 20050048593
    Abstract: The present inventors have discovered that ALS catalytic and regulatory subunits are essential for normal fungal pathogenicity. Specifically, the inhibition of either ALS catalytic or regulatory subunit gene expression in fungi severely reduces growth and pathogenicity. Thus, ALS catalytic and regulatory subunits are useful as targets for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit ALS catalytic or regulatory subunit expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: June 25, 2004
    Publication date: March 3, 2005
    Inventors: Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey, Jeffrey Shuster, Matthew Tanzer, Lisbeth Hamer, Kiichi Adachi
  • Methods for the identification of inhibitors of mannosyltransferase as antibiotics
    Publication number: 20050042705
    Abstract: The present inventors have discovered that mannosyltransferase is essential for normal fungal growth and pathogenicity. Specifically, the inhibition of mannosyltransferase gene expression in fungi results in drastically reduced growth and pathogenicity. Thus, mannosyltransferase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit mannosyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: June 23, 2004
    Publication date: February 24, 2005
    Inventors: Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey, Matthew Tanzer, Jeffrey Shuster, Lisbeth Hamer
  • Methods for the identification of inhibitors of porphobilinogen deaminase as antibiotics
    Publication number: 20050042706
    Abstract: The present inventors have discovered that porphobilinogen deaminase (PBG) is essential for normal fungal pathogenicity. Specifically, the inhibition of porphobilinogen deaminase gene expression in fungi abolishes pathogenicity. Thus, porphobilinogen deaminase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit porphobilinogen deaminase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: March 17, 2004
    Publication date: February 24, 2005
    Inventors: Matthew Tanzer, Jeffrey Shuster, Todd DeZwaan, Amy Covington, Maria Montenegro-Chamorro, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Rex Tarpey, Lisbeth Hamer, Kiichi Adachi, Sze-Chung Lo, Blaise Darveaux
  • Methods for the identification of inhibitors of fumarate reductase as antibiotics
    Publication number: 20050026237
    Abstract: The present inventors have discovered that fumarate reductase is essential for normal fungal pathogenicity. Specifically, the inhibition of fumarate reductase gene expression in fungi results in drastically reduced pathogenicity. Thus, fumarate reductase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit fumarate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: June 9, 2004
    Publication date: February 3, 2005
    Inventors: Matthew Tanzer, Jeffrey Shuster, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey
  • Methods for the identification of inhibitors of ornithine carbamoyltransferase as antibiotics
    Publication number: 20050019846
    Abstract: The present inventors have discovered that ornithine carbamoyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of ornithine carbamoyltransferase gene expression in fungi eliminates pathogenicity. Thus, ornithine carbamoyltransferase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit ornithine carbamoyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: May 20, 2004
    Publication date: January 27, 2005
    Inventors: Matthew Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Montenegro-Chamorro, Blaise Darveaux, Sheryl Frank, Ryan Heiniger, Sanjoy Mahanty, Huaqin Pan, Amy Covington, Rex Tarpey, Jeffrey Shuster
  • Methods for the identification of inhibitors of threonine synthase as antibiotics
    Patent number: 6806060
    Abstract: The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: October 19, 2004
    Assignee: Icoria, Inc.
    Inventors: Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo
  • Methods for the identification of inhibitors of Trehalose-6-Phosphate Synthase as antibiotics
    Publication number: 20040146960
    Abstract: The present inventors have discovered that Trehalose-6-Phosphate Synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of Trehalose-6-Phosphate Synthase gene expression in fungi results in reduced pathogenicity (i.e. smaller, non-viable lesions). Thus, Trehalose-6-Phosphate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Trehalose-6-Phosphate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: November 7, 2003
    Publication date: July 29, 2004
    Inventors: Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Covington, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank
  • Methods for the identification of inhibitors of histidinol-phosphate as antibiotics
    Patent number: 6740498
    Abstract: The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: May 25, 2004
    Assignee: Paradigm Genetics, Inc.
    Inventors: Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer
  • Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
    Patent number: 6733963
    Abstract: The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: May 11, 2004
    Assignee: Paradigm Genetics, Inc.
    Inventors: Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer
  • Methods for the identification of inhibitors of 5-aminolevulinate synthase as antibiotics
    Patent number: 6689578
    Abstract: The present inventors have discovered that 5-Aminolevulinate synthase is essential for fungal pathogenicity. Specifically, the inhibition of 5-Aminolevulinate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, 5-Aminolevulinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 5-Aminolevulinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: February 10, 2004
    Assignee: Paradigm Genetics, Inc.
    Inventors: Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamarro, Sheryl Frank, Blaise Darveaux, Sanjoy K. Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi
  • Methods for the identification of inhibitors of histidinol-phosphate as antibiotics
    Publication number: 20030148412
    Abstract: The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: December 6, 2001
    Publication date: August 7, 2003
    Inventors: Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer
  • Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
    Publication number: 20030143657
    Abstract: The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: December 6, 2001
    Publication date: July 31, 2003
    Inventors: Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer
  • METHODS FOR THE IDENTIFICATION OF INHIBITORS OF 5-AMINOLEVULINATE SYNTHASE AS ANTIBIOTICS
    Publication number: 20030124642
    Abstract: The present inventors have discovered that 5-Aminolevulinate synthase is essential for fungal pathogenicity. Specifically, the inhibition of 5-Aminolevulinate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, 5-Aminolevulinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 5-Aminolevulinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: December 6, 2001
    Publication date: July 3, 2003
    Inventors: Todd DeZwaan, Sze-Chung Lo, Maria Victoria Montenegro-Chamarro, Sheryl Frank, Blaise Darveaux, Sanjoy K. Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi
  • Methods for the identification of inhibitors of threonine synthase as antibiotics
    Publication number: 20030108979
    Abstract: The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
    Type: Application
    Filed: December 7, 2001
    Publication date: June 12, 2003
    Inventors: Maria Victoria Montenegro-Chamorro, Sheryl Frank, Blaise Darveaux, Sanjoy Mahanty, Ryan Heiniger, Amy Skalchunes, Huaqin Pan, Rex Tarpey, Jeffrey Shuster, Matthew M. Tanzer, Lisbeth Hamer, Kiichi Adachi, Todd DeZwaan, Sze-Chung Lo