Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.

Abstract: The present disclosure relates to a method of treating cellulite on a thigh or buttock in a human subject by administering an effective amount of collagenase, and then assessing the reduction in the severity of cellulite by one or more scales.

Abstract: There are provided systems and methods for monitoring a property using a system of sensor units in one or more premises on the property that can interface with respective utilities entering the premises or being generated by appliances on the premises with a minimal of effort and without requiring modification of the utility's equipment or the appliance. The systems and methods are connectable to a cloud-based monitoring, analytics and notification system via a long range network connection directly from one or more of the sensor units. The system of sensors can also incorporate primary and secondary units with at least one primary unit capable of communicating directly to the cloud-based system/server via a long-range connection with the secondary units sending data to the cloud via the primary unit by communicating at the property via a short-range communication connection.

Abstract: An integrated sensor and service port for HVAC (heating, ventilating, and air conditioning) equipment or an HVAC system.

Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.

Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.

Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.

Abstract: An integrated sensor and service port for HVAC (heating, ventilating, and air conditioning) equipment or an HVAC system.

Abstract: There are provided systems and methods for monitoring a property using a system of sensor units in one or more premises on the property that can interface with respective utilities entering the premises or being generated by appliances on the premises with a minimal of effort and without requiring modification of the utility's equipment or the appliance. The systems and methods are connectable to a cloud-based monitoring, analytics and notification system via a long range network connection directly from one or more of the sensor units. The system of sensors can also incorporate primary and secondary units with at least one primary unit capable of communicating directly to the cloud-based system/server via a long-range connection with the secondary units sending data to the cloud via the primary unit by communicating at the property via a short-range communication connection.

Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.

Abstract: Systems and methods to provide respiratory therapy may determine a target pressure level in a current therapy session on the successful completion and/or compliance of a patient (for example for at least a threshold amount of respiratory therapy) during one or more prior therapy sessions. By gradually increasing the provided pressure level, patients may improve compliance, comfort, and/or other indicators of how well-tolerated the respiratory therapy is for a patient.

Abstract: A vestibular stimulation system and method that includes a housing, a power supply disposed in the housing, an electrode assembly adapted to be coupled to the housing, and a controller disposed in the housing and operatively coupled to the power supply. The controller controls the delivery of energy from the power supply to the electrode assembly. An input element is also disposed on an exterior surface of the housing. The input element is manually manipulated to control the operation of the vestibular stimulation system. A display disposed on an exterior surface of the housing provides visual information regarding the operation of the vestibular stimulation system. A mounting assembly is coupled to the housing to mount the housing on such a user.

Abstract: The present invention relates to methods and compositions for treating pain in a subject and safely transitioning a subject from a full ?-opioid receptor agonist to a partial ?-opioid receptor agonist.

Abstract: The present disclosure describes a system configured to stimulate a vestibular system of a user while the user is in a sleeping position. The system comprises a housing; a power supply; an electrode assembly; a controller that controls stimulation of the vestibular system through delivery of energy from the power supply to the electrode assembly; an input element configured to control operation of the system; an auditory output device that provides auditory output to the user, wherein the auditory output is synchronized with the stimulation of the vestibular system to enhance an effect of the stimulation; a mounting assembly for mounting the housing on the user; and a sensor adapted to generate an output signal related to a physiological parameter of the user, wherein the controller controls the electrode assembly to cease delivery of the energy responsive to the output signal indicating that the user is leaving the sleeping position.

Abstract: Systems and methods to provide respiratory therapy may determine a target pressure level in a current therapy session on the successful completion and/or compliance of a patient (for example for at least a threshold amount of respiratory therapy) during one or more prior therapy sessions. By gradually increasing the provided pressure level, patients may improve compliance, comfort, and/or other indicators of how well-tolerated the respiratory therapy is for a patient.

Abstract: A system configured to provide breathing cues to a patient to alleviate insomnia or sleeplessness. In one embodiment, the system comprises a pressure support apparatus, a patient monitor, and a processor. The pressure support apparatus is configured to provide a pressurized flow of gas for delivery to an airway of the patient. The patient monitor configured to generate one or more signals that convey information related to one or more physiological functions of the patient. The processor in operative communication with each of the pressure support apparatus and the patient monitor.

Abstract: A vestibular stimulation system and method that includes a housing, a power supply disposed in the housing, an electrode assembly adapted to be coupled to the housing, and a controller disposed in the housing and operatively coupled to the power supply. The controller controls the delivery of energy from the power supply to the electrode assembly. An input element is also disposed on an exterior surface of the housing. The input element is manually manipulated to control the operation of the vestibular stimulation system. A display disposed on an exterior surface of the housing provides visual information regarding the operation of the vestibular stimulation system. A mounting assembly is coupled to the housing to mount the housing on such a user.

Abstract: A system and method for regulating one or more physiological functions controlled by a hypothalamus of an individual. In one embodiment, a stimulation is applied to at least a portion of a vestibular system of the individual, a subjective input is received from the individual based upon the individual's perceived response of the hypothalamus in regulating the one or more physiological functions, and the stimulation is adjusted based on the received subjective input.

Abstract: A method of treating sleep disordered breathing in a patient includes the steps of monitoring the patient for a pre-inspiratory drive signal indicative of the breathing cycle by sensing electroneurogram activity of a hypoglossal nerve of the patient; and electrically stimulating the hypoglossal nerve of the patient following each detection of the pre-inspiratory drive signal. An implantable apparatus for stimulating a hypoglossal nerve of a patient for the treatment of sleep disordered breathing includes an electrode positioned at least partially around the hypoglossal nerve with a monitoring contact and a stimulation contact and a controller operatively coupled to the monitoring contact and the stimulation contact. The monitoring contact monitors the electroneurogram activity of the hypoglossal nerve for a pre-inspiratory drive signal indicative of the onset of inspiration and sends a signal to the controller which in turn causes the stimulating electrode to electrically stimulate the hypoglossal nerve.

Abstract: One aspect of the invention relates to a patient treatment system that delivers a pressurized flow of breathable gas to a patient. The system comprises a baseline module, a treatment measurement module, and a report module. The baseline module determines a baseline amount of treatment the patient should receive from the patient treatment system during a first time interval. The treatment measurement module measures an amount of treatment received by the patient during a second time interval. The report module generates a treatment report based upon the measured amount of treatment received by the patient during the second time interval and the baseline amount of treatment the patient should receive during the first time interval.