Abstract: A protective cover for a computer mouse made of an elastic, flexible material. The material, having a cupped shape, stretches over the top and sides of the mouse, held firmly in place by the elastic action. The bottom of the mouse is left open for proper use. In order to maintain functionality of the mouse buttons, the material is relatively thin. Various indicia may be provided on the cover, which may be transparent or any of a variety of colors. The cover may also be provided with various textures for tactile and aesthetic enhancement.