Abstract: [Objective] To provide a method and apparatus for seamless tubes in which the occurrence of material peeling can be prevented even when the skew angle ? and tube expansion ratio are increased. [Means for solution] A piercing-rolling method for seamless tubes using a piercer, which is provided with a pair of cone-shaped main rolls and a pair of disk rolls, each pair being arranged in an opposing manner with a pass line therebetween as a center axis, and a plug whose center axis coincides with the pass line, wherein a billet to be pierced and rolled is advanced while being spirally rotated by a drive rotation of the main rolls; the method of which is characterized in each of the disk rolls being arranged in an inclined state at a fixed skew angle ? to the pass line.

Abstract: A compound represented by the formula (I) or a salt of the compound, and a PPAR-? activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; each of R4 and R5 represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring).

Abstract: The present invention provides a seamless tube piercing/rolling plug and a seamless tube producing method in which piercing/rolling is performed with an inclined rotary piercing mill while the seamless tube piercing/rolling plug is used as a piercing tool. The seamless tube piercing/rolling plug is used while a front part and a rear part of the split plug are held as an integral plug, at least the front part is made of low alloy steel, and oxide films are formed on surfaces of the front part and rear part. The present invention also provides a seamless tube piercing/rolling apparatus and a seamless tube producing method in which the front part and/or rear part is replaceable in a tube making process line using the seamless tube piercing/rolling apparatus.

Abstract: A seamless tube producing method uses a piercing/rolling plug wherein piercing/rolling is performed with an inclined rotary piercing mill while the seamless tube piercing/rolling plug is used as a piercing tool. In one mode, a front part and a rear part of the split plug are held as an integral plug, the front part being made of low alloy steel, and oxide films are formed on surfaces of the front part and rear part. In a second mode, the front part and/or rear part are replaceable via a removable mounting wherein a mandrel bar holding the plug goes through the rear part, the mandrel bar being coupled with the front part. A thickness of the oxide film formed in the front part can be 200 ?m or more and the oxide film of the front part can be thicker than the oxide film of the rear part.

Abstract: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(?O), CH?CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-? activator which contains the compound or salt as the active ingredient.

Abstract: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(?O), CH?CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-? activator which contains the compound or salt as the active ingredient.

Abstract: The invention relates to compounds of the following formula (I) or their salts: in which R1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R2 is cyano, nitro, or the like; R3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.

Abstract: The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which may have a substituent or the like; R2 is halogen, nitro, cyano, carboxyl, or the like; R3 is hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR11, oxygen, or sulfur, in which R11 is hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CR12 or nitrogen, in which R12 has the same meaning as R3 above, and a xanthine oxidase inhibitor containing the compound as an active ingredient.

Abstract: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(?O), CH?CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-? activator which contains the compound or salt as the active ingredient.

Abstract: A pierced shell of an austenitic stainless steel having a good inner surface condition is provided, and a means is established which can perform mass production on an industrial scale of a good quality seamless steel pipe of stainless steel. An austenitic stainless steel billet with a P content of at most 0.040% and an S content of at most 0.020% is pierced under conditions such that the pipe expansion ratio H (outer diameter of shell/diameter of billet to be worked) satisfies the following equation to obtain a tube shell of an austenitic stainless steel. {P(%)/(0.025×H?0.01)}2+{S(%)/(0.015×H?0.01)}2?1. When manufacturing a seamless steel pipe of an austenitic stainless steel, the above-described shell is rolled to form a pipe.

Abstract: A Ni base alloy pipe stock having a chemical composition comprising, by mass %, C?0.04%, Si?0.50%, Mn: 0.01 to 6.0%, P?0.03%, S?0.01%, Cr: 15 to 30%, Ni: more than 45% to not more than 60%, Mo: 0 to 18%, W: 0 to 36%, with Mo(%)+0.5W(%): more than 1.5% to not more than 18%, Cu: 0.01 to 1.5%, Al?0.01% and N: 0.0005 to 0.20%, and the balance substantially being Fe, with 1380?5000P?100S?4400C?1300, Ni+10(Mo+0.5W)+100N?200, (Ni?50)+10(N?0.1)?2(Cr?25)?5(Mo+0.5W?6)+12?0, can be manufactured into a seamless pipe by use of a Mannesmann piercing and rolling mill because of its excellent inner surface properties. The resulting seamless pipe has excellent mechanical properties and moreover has excellent corrosion resistance in a sour gas environment, and thus, the Ni base alloy pipe stock can be used as a pipe stock for oil country tubular goods and line pipes and further as a pipe stock for various structural members of nuclear power plants and chemical industrial plants.

Abstract: The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which may have a substituent or the like; R2 is halogen, nitro, cyano, carboxyl, or the like; R3 is hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR11, oxygen, or sulfur, in which R11 is hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CR12 or nitrogen, in which R12 has the same meaning as R3 above, and a xanthine oxidase inhibitor containing the compound as an active ingredient.

Abstract: An Fe—Ni alloy pipe stock having a chemical composition comprising, by mass %, C?0.04%, Si?0.50%, Mn: 0.01 to 6.0%, P?0.03%, S?0.01%, Cr: 20 to 30%, Ni: 30 to 45%, Mo: 0 to 10%, W: 0 to 20%, with Mo(%)+0.5W(%): more than 1.5% to not more than 10%, Cu: 0.01 to 1.5%, Al?0.01% and N: 0.0005 to 0.20%, and the balance substantially being Fe, with 1440?6000P?100S?2000C?1300, Ni+10(Mo+0.5W)+100N?120, (Ni?35)+10(N?0.1)?2(Cr?25)?5(Mo+0.5W?3)+8?0, can be manufactured into a seamless pipe by use of a Mannesmann piercing and rolling mill because of its excellent inner surface properties. The resulting seamless pipe has excellent mechanical properties and moreover has excellent corrosion resistance in a sour gas environment, and thus, the Fe—Ni alloy pipe stock can be used as a pipe stock for oil country tubular goods and line pipes and further as a pipe stock for various structural members of nuclear power plants and chemical industrial plants.

Abstract: A compound represented by the formula (I) or a salt of the compound, and a PPAR-? activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; each of R4 and R5 represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring).

Abstract: A seamless tube producing method uses a piercing/rolling plug wherein piercing/rolling is performed with an inclined rotary piercing mill while the seamless tube piercing/rolling plug is used as a piercing tool. In one mode, a front part and a rear part of the split plug are held as an integral plug, the front part being made of low alloy steel, and oxide films are formed on surfaces of the front part and rear part. In a second mode, the front part and/or rear part are replaceable via a removable mounting wherein a mandrel bar holding the plug goes through the rear part, the mandrel bar being coupled with the front part. A thickness of the oxide film formed in the front part can be 200 ?m or more and the oxide film of the front part can be thicker than the oxide film of the rear part.

Abstract: A pierced shell of an austenitic stainless steel having a good inner surface condition is provided, and a means is established which can perform mass production on an industrial scale of a good quality seamless steel pipe of stainless steel. An austenitic stainless steel billet with a P content of at most 0.040% and an S content of at most 0.020% is pierced under conditions such that the pipe expansion ratio H (outer diameter of shell/diameter of billet to be worked) satisfies the following equation to obtain a tube shell of an austenitic stainless steel. {P(%)/(0.025×H?0.01)}2+{S(%)/(0.015×H?0.01)}2?1 When manufacturing a seamless steel pipe of an austenitic stainless steel, the above-described shell is rolled to form a pipe.

Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.

Abstract: The invention relates to (1S)-1-isobutoxymethyl-3-methylbutylamine useful as an intermediate in the synthesis of sodium (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylate and a process for production thereof. The process comprises reacting L-leucinol with a compound represented by the following formula in the presence of a base and reducing the obtained (1S)-1-(2-methyl-2-propenoxymethyl)-3-methylbutyl-amine: [in which X is a leaving group].

Abstract: A compound represented by the formula (I) or a salt of the compound, and a PPAR-? activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; Z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; each of R4 and R5 represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring).

Abstract: A method of manufacturing a seamless tube by the invention can duly control the rotary forging effect without miss-rolling such as defective onset engagement with rolls by satisfying either of (1)–(3) formulas below, dependent on a given range of roll diameter ratio Dg/D1, prevent the occurence of internal surface flaws at the top of the work material attributable to deteriorated hot workability, and further prevent the occurrence of said flaws over the remaining length without altering parameters for piercing-rolling process. Thus, the invention can be widely utilized as an excellent manufacturing method for said tube: in case of Dg/D1<1.1, 23?N/(Df/100)?40,??(1) in case of 1.1?Dg/D1<1.5, 20?N/(Df/100)?44,??(2) in case of 1.5?Dg/D1?1.8, 20?N/(Df/100)?48.