Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: A pressing apparatus associated with an absorbent article, including: a pair of rollers that are driven and rotate with outer circumferential surfaces thereof facing each other, when a fibrous continuous sheet overlapped with an article to be overlapped with a thermoplastic adhesive therebetween is passed in a continuous direction of the fibrous continuous sheet through a roller gap between the pair of rollers, the pressing apparatus sandwiching and pressing the article to be overlapped and the fibrous continuous sheet between the outer circumferential surfaces, and a heating mechanism that heats at least a roller of the pair of rollers that is positioned on a side of the fibrous continuous sheet, the heating mechanism heating the roller so as to keep a temperature of the outer circumferential surface of the roller within a range from 70° C. to 120° C.

Abstract: A rotary drum for a fiber-stacking device includes a drum body, pattern plates each having a single fiber-stacking depression, and holding mechanisms each detachably holding a corresponding pattern plate on the outer circumferential surface of the drum body. Each holding mechanism has a fixed hook and a moveable hook. The fixed hook is immovably attached to one side of the drum body and forms a first groove with the drum body. The movable hook is attached to the other side of the drum body to be moveable between a holding position and a release position, forms a second groove with the drum body at the holding position, and opens the second groove at the release position. When the movable hook is at the holding position, the two side parts of the pattern plate are accommodated inside the first and second grooves.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: A rotary drum for a fiber-stacking device includes a drum body, pattern plates each having a single fiber-stacking depression, and holding mechanisms each detachably holding a corresponding pattern plate on the outer circumferential surface of the drum body. Each holding mechanism has a fixed hook and a moveable hook. The fixed hook is immovably attached to one side of the drum body and forms a first groove with the drum body. The movable hook is attached to the other side of the drum body to be moveable between a holding position and a release position, forms a second groove with the drum body at the holding position, and opens the second groove at the release position. When the movable hook is at the holding position, the two side parts of the pattern plate are accommodated inside the first and second grooves.

Abstract: A pressing apparatus associated with an absorbent article, including: a pair of rollers that are driven and rotate with outer circumferential surfaces thereof facing each other, when a fibrous continuous sheet overlapped with an article to be overlapped with a thermoplastic adhesive therebetween is passed in a continuous direction of the fibrous continuous sheet through a roller gap between the pair of rollers, the pressing apparatus sandwiching and pressing the article to be overlapped and the fibrous continuous sheet between the outer circumferential surfaces, and a heating mechanism that heats at least a roller of the pair of rollers that is positioned on a side of the fibrous continuous sheet, the heating mechanism heating the roller so as to keep a temperature of the outer circumferential surface of the roller within a range from 70° C. to 120° C.

Abstract: A log management apparatus is coupled to a plurality of terminal equipments via at least one network and manages a log of a file operation performed from one of the plurality of terminal equipments with respect to a file of another one of the plurality of terminal equipments. An input and output section to obtain data via the network, and to obtain and store trace data in a trace file by starting a trace in response to a file operation, an extracting section to automatically extract predetermined modified contents with respect to a file from the trace file, and a storing section to store the predetermined modified contents in a modification log file, are provided.