Patents by Inventor Tomohiro Yoshikawa
Tomohiro Yoshikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240173624Abstract: A game control method, game server, and program can increase variations on methods for acquiring items, increase the predictability of acquisition of an item with a high rarity value or the like, and heighten interest in the game. Included are the steps of presenting a communication terminal, connected over a communication line, with acquirable item information that, for each item type, includes a total count and an acquisition count or a non-acquisition count of items when receiving, from the communication terminal, a request to present information related to items acquirable by the communication terminal, determining an item to provide to the communication terminal when receiving an item acquisition request from the communication terminal, and changing the acquirable item information when receiving a reset request from the communication terminal.Type: ApplicationFiled: February 5, 2024Publication date: May 30, 2024Applicant: GREE, INC.Inventors: Tsuyoshi YOSHIKAWA, Tomohiro TSUKIHARA, Norikazu KATO, Tomoki YASUHARA
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Patent number: 11918917Abstract: A game control method, game server, and program can increase variations on methods for acquiring items, increase the predictability of acquisition of an item with a high rarity value or the like, and heighten interest in the game. Included are the steps of presenting a communication terminal, connected over a communication line, with acquirable item information that, for each item type, includes a total count and an acquisition count or a non-acquisition count of items when receiving, from the communication terminal, a request to present information related to items acquirable by the communication terminal, determining an item to provide to the communication terminal when receiving an item acquisition request from the communication terminal, and changing the acquirable item information when receiving a reset request from the communication terminal.Type: GrantFiled: April 4, 2023Date of Patent: March 5, 2024Assignee: GREE, INC.Inventors: Tsuyoshi Yoshikawa, Tomohiro Tsukihara, Norikazu Kato, Tomoki Yasuhara
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Publication number: 20240066047Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.Type: ApplicationFiled: May 1, 2023Publication date: February 29, 2024Inventors: MASATO YOSHIKAWA, MORIHISA SAITOH, TAISUKE KATO, YAYOI NAKAYAMA, TOMOHIRO SEKI, YASUO NAKAGAWA, YUSUKE TOMINARI, MASAKI SETO, YUSUKE SASAKI, MASANORI OKANIWA, TSUNEO ODA, AKITO SHIBUYA, KOSUKE HIDAKA, ZENYU SHIOKAWA, SHUMPEI MURATA, ATSUTOSHI OKABE, YOSHIHISA NAKADA, MICHIYO MOCHIZUKI, BRIAN SCOTT FREEZE, TAISUKE TAWARAISHI, YASUFUMI WADA, PAUL D. GREENSPAN
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Patent number: 11179905Abstract: A method and device for manufacturing the tire are provided. For each tire obtained by feeding green tires having an identical specification into an identical vulcanizer, using an arrangement mechanism, with circumferential positions of the green tires varied with respect to the vulcanizer and vulcanizing the green tires, a storage unit stores characteristic value data of at least one of a UF or DB value and feed position data identifying the circumferential position of the green tires, a calculation unit calculates, based on the stored data, the circumferential position of the green tires with respect to the vulcanizer at which a characteristic value related to the characteristic value data is brought within a tolerance range, and feeding using the arrangement mechanism, into the vulcanizer, the green tire to be newly vulcanized while adjusting the green tire to the circumferential position with respect to the vulcanizer being calculated.Type: GrantFiled: March 25, 2019Date of Patent: November 23, 2021Inventors: Tomohiro Yoshikawa, Taisuke Kimura
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Publication number: 20210138748Abstract: A method and device for manufacturing the tire are provided. For each tire obtained by feeding green tires having an identical specification into an identical vulcanizer, using an arrangement mechanism, with circumferential positions of the green tires varied with respect to the vulcanizer and vulcanizing the green tires, a storage unit stores characteristic value data of at least one of a UF or DB value and feed position data identifying the circumferential position of the green tires, a calculation unit calculates, based on the stored data, the circumferential position of the green tires with respect to the vulcanizer at which a characteristic value related to the characteristic value data is brought within a tolerance range, and feeding using the arrangement mechanism, into the vulcanizer, the green tire to be newly vulcanized while adjusting the green tire to the circumferential position with respect to the vulcanizer being calculated.Type: ApplicationFiled: March 25, 2019Publication date: May 13, 2021Inventors: Tomohiro Yoshikawa, Taisuke Kimura
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Patent number: 10344042Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, in which NR40R50 are together.Type: GrantFiled: June 16, 2017Date of Patent: July 9, 2019Assignees: Stella Pharma Corporation, Osaka Prefecture University Public CorporationInventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
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Patent number: 10005794Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, wherein NR40R50 are together.Type: GrantFiled: December 16, 2014Date of Patent: June 26, 2018Assignees: STELLA PHARMA CORPORATION, OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATIONInventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
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Patent number: 9815855Abstract: 18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of 18F-labeled BPA represented by the following formula: in which R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3? or BX3?M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).Type: GrantFiled: January 28, 2015Date of Patent: November 14, 2017Assignees: Stella Pharma Corporation, Osaka Prefecture University Public CorporationInventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
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Publication number: 20170283441Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, in which NR40R50 are together.Type: ApplicationFiled: June 16, 2017Publication date: October 5, 2017Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
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Publication number: 20170015684Abstract: 18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of 18F-labeled BPA represented by the following formula: in which R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3? or BX3?M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).Type: ApplicationFiled: January 28, 2015Publication date: January 19, 2017Inventors: Hiroshi TAKENAKA, Yoichiro OHTA, Yusuke TAGUCHI, Sayuri UEDA, Yuko ISHINO, Tomohiro YOSHIKAWA, Hideki NAKASHIMA, Kohki UEHARA, Mitsunori KIRIHATA
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Publication number: 20160311836Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, wherein NR40R50 are together.Type: ApplicationFiled: December 16, 2014Publication date: October 27, 2016Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
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Patent number: 8710024Abstract: The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.Type: GrantFiled: May 11, 2012Date of Patent: April 29, 2014Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Misako Nakazawa, Shin-etsu Kadowaki, Yoshiji Fujita, Masato Miyake, Takanori Ueda, Tomohiro Yoshikawa
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Publication number: 20140045889Abstract: This invention relates to a combination drug comprising a combination of a tetrazolylalkoxy-dihydrocarbostyril derivative of the formula: wherein R is cycloalkyl, A is lower alkylene, and the bond between 3- and 4-positions of carbostyril nucleus is single bond or double bond, or a salt thereof and Probucol, which is useful for preventing and treating cerebral infarction including acute cerebral infarction and chronic cerebral infarction, arteriosclerosis, renal diseases (e.g. diabetic nephropathy, renal failure, nephritis), and diabetes owing to synergistic superoxide suppressant effects of the combination.Type: ApplicationFiled: October 21, 2013Publication date: February 13, 2014Applicant: Otsuka Pharmaceutical Co., Ltd.Inventors: Ki Whan HONG, Tomohiro YOSHIKAWA
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Patent number: 8580818Abstract: This invention relates to a combination drug comprising a combination of a tetrazolylalkoxy-dihydrocarbostyril derivative of the formula: wherein R is cycloalkyl, A is lower alkylene, and the bond between 3- and 4-positions of carbostyril nucleus is single bond or double bond, or a salt thereof and Probucol, which is useful for preventing and treating cerebral infarction including acute cerebral infarction and chronic cerebral infarction, arteriosclerosis, renal diseases (e.g. diabetic nephropathy, renal failure, nephritis), and diabetes owing to synergistic superoxide suppressant effects of the combination.Type: GrantFiled: September 14, 2006Date of Patent: November 12, 2013Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Ki Whan Hong, Tomohiro Yoshikawa
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Publication number: 20120232128Abstract: The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.Type: ApplicationFiled: May 11, 2012Publication date: September 13, 2012Applicant: KYORIN PHARMACEUTICAL CO., LTD.Inventors: Misako NAKAZAWA, Shin-etsu Kadowaki, Yoshiji Fujita, Masato Miyake, Takanori Ueda, Tomohiro Yoshikawa
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Patent number: 8198256Abstract: The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.Type: GrantFiled: July 2, 2008Date of Patent: June 12, 2012Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Misako Nakazawa, Shin-etsu Kadowaki, Yoshiji Fujita, Masato Miyake, Takanori Ueda, Tomohiro Yoshikawa
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Publication number: 20110165664Abstract: There is provided a transfection device having a mixture (1) immobilized on a solid-phase support (3), the mixture including: a gene sample; a gene delivery material; and at least one compound selected from the group consisting of sericin, a hydrolysate thereof and a chemically modified product of sericin or a hydrolysate thereof.Type: ApplicationFiled: August 22, 2008Publication date: July 7, 2011Applicant: CYTOPATHFINDER, INC.Inventors: Yoshiji Fujita, Tomohiro Yoshikawa
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Publication number: 20110004415Abstract: It is intended to provide a method and system for carrying out data production with respect to the actual status of cells as a profile. It is also intended to provide a system and method for presenting time-lapse and/or real-time information of cell interior directly, or as it is, from the viewpoint of a complex system. It is further intended to provide a method of presenting a digital cell. Thus, there is provided a method of producing profile data relating to cell information, comprising the step (a) of arranging cells in an immobilized form on a support and the step (b) of monitoring over time biological factors on or inside the cells or an aggregate thereof, thereby producing profile data for the cells. Furthermore, there is provided a method of producing a digital cell, comprising procuring experimental data by the use of the above method.Type: ApplicationFiled: June 25, 2010Publication date: January 6, 2011Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: MASATO MIYAKE, TOMOHIRO YOSHIKAWA, JUN MIYAKE
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Publication number: 20100280096Abstract: The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.Type: ApplicationFiled: July 2, 2008Publication date: November 4, 2010Applicants: KYORIN PHARMACEUTICAL CO., LTD., CYTOPATHFINDER, INC.Inventors: Misako Nakazawa, Shin-etsu Kadowaki, Yoshiji Fujita, Masato Miyake, Takanori Ueda, Tomohiro Yoshikawa
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Patent number: 7747390Abstract: It is intended to provide a method and system for carrying out data production with respect to the actual status of cells as a profile. It is also intended to provide a system and method for presenting time-lapse and/or real-time information of cell interior directly, or as it is, from the viewpoint of a complex system. It is further intended to provide a method of presenting a digital cell. Thus, there is provided a method of producing profile data relating to cell information, comprising the step (a) of arranging cells in an immobilized form on a support and the step (b) of monitoring over time biological factors on or inside the cells or an aggregate thereof, thereby producing profile data for the cells. Furthermore, there is provided a method of producing a digital cell, comprising procuring experimental data by the use of the above method.Type: GrantFiled: June 25, 2004Date of Patent: June 29, 2010Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Masato Miyake, Tomohiro Yoshikawa, Jun Miyake