Patents by Inventor Tomohisa Nishio
Tomohisa Nishio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230003746Abstract: The present invention addresses the problem of providing a method for measuring 25-hydroxy vitamin D and a measurement reagent, the method and the reagent being based on a competitive immunoassay. The present invention provides a reagent for measuring 25-hydroxy vitamin D based on a competitive immunoassay, which includes at least the following composition: (1) a Vitamin D derivative represented by the chemical formula (I) and/or (II), (2) an anti-25 hydroxy vitamin D antibody. In addition, the present invention provides a reagent for measuring vitamin D based on a competitive latex turbidimetric immunoassay (competitive LTIA) in which, in particular, a vitamin D derivative or an anti-25-hydroxy vitamin D antibody is immobilized on latex.Type: ApplicationFiled: November 20, 2020Publication date: January 5, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mitsuaki YAMAMOTO, Mieko OTA, Tomohisa NISHIO
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Publication number: 20220349911Abstract: An automatic analysis apparatus is capable of stirring a reagent without reducing the analysis processing capacity. The automatic analysis apparatus includes a reagent table that is rotatable and that holds reagent vessels, and a plurality of magnets are disposed below the reagent table, with orientations of magnetic poles of the magnets fixed, along a movement path of the reagent vessels moving on a circumference when the reagent table is rotationally driven. The plurality of magnets is disposed such that the fixed orientations of the magnetic poles of the magnets vary along the movement path, and act a magnetic force on a stirring bar in each of the reagent vessels. When the reagent table is rotated and the reagent vessels pass above the magnets, the stirring bar in each of the reagent vessels is rotated or oscillated by the magnetic force received from the magnets, to stir the reagent.Type: ApplicationFiled: July 7, 2022Publication date: November 3, 2022Inventors: Toshiki KAWABE, Tomohisa NISHIO, Hirotoshi MATSUSHITA, Shota TAKIMORI, Toyomi YAMAGUCHI
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Patent number: 11220704Abstract: Provided is a method of avoiding the influence of a coexisting substance in the measurement of HbA1c % for a whole blood sample by an enzymatic method. Specifically, provided is a method of measuring a ratio of a hemoglobin A1c concentration to a hemoglobin concentration in a sample by an enzymatic method, the method including: a first step of optically measuring the hemoglobin concentration; and a second step of optically measuring the hemoglobin A1c concentration, wherein, when HbA1c % is calculated by dividing the hemoglobin A1c concentration measured in the second step by the hemoglobin concentration measured in the first step, the hemoglobin concentration serving as a denominator, which is measured at a first wavelength, is corrected using a result measured at a second wavelength.Type: GrantFiled: August 10, 2017Date of Patent: January 11, 2022Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Satoshi Machida, Tomohisa Nishio, Kazuo Nakanishi
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Publication number: 20210405072Abstract: A method for controlling MNPT is required. Coexistence of a specific metal ion with tissue thromboplastin enables MNPT to be controlled/adjusted to a desired time. Coexistence of the specific metal ion with tissue thromboplastin also enables improvement of stability when a thromboplastin reagent is stored in a solution form.Type: ApplicationFiled: September 25, 2019Publication date: December 30, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Kengo OONISHI, Yoshimasa BANBA, Tomohisa NISHIO
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Publication number: 20210389306Abstract: A problem to be solved is to provide a glycated hemoglobin (%) assay method and assay reagent capable of accurate measurement of glycated hemoglobin (%) in blood even when a blood specimen containing hemoglobin contains abnormal hemoglobin such as HbS or HbC. The present invention provides a method capable of accurate measurement of glycated hemoglobin (%) in blood even in a specimen containing abnormal hemoglobin by combining two types of monoclonal antibodies, i.e., an anti-glycated hemoglobin monoclonal antibody and a monoclonal antibody to the anti-glycated hemoglobin monoclonal antibody, and an assay reagent for performing the method.Type: ApplicationFiled: September 27, 2019Publication date: December 16, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mieko OTA, Osamu MIYAZAKI, Satoko SEO, Mitsuaki YAMAMOTO, Tomohisa NISHIO
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Publication number: 20190169674Abstract: Provided is a method of avoiding the influence of a coexisting substance in the measurement of HbA1c % for a whole blood sample by an enzymatic method. Specifically, provided is a method of measuring a ratio of a hemoglobin A1c concentration to a hemoglobin concentration in a sample by an enzymatic method, the method including: a first step of optically measuring the hemoglobin concentration; and a second step of optically measuring the hemoglobin A1c concentration, wherein, when HbA1c % is calculated by dividing the hemoglobin A1c concentration measured in the second step by the hemoglobin concentration measured in the first step, the hemoglobin concentration serving as a denominator, which is measured at a first wavelength, is corrected using a result measured at a second wavelength.Type: ApplicationFiled: August 10, 2017Publication date: June 6, 2019Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Satoshi MACHIDA, Tomohisa NISHIO, Kazuo NAKANISHI
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Publication number: 20080241816Abstract: A method of storing/stabilizing an oxidizable color-assuming reagent, especially a leuco dye; and a stabilized reagent obtained thereby. The method of stabilizing an oxidizable color-assuming reagent comprises storing the oxidizable color-assuming reagent in a solution having a pH of 1 to 5.Type: ApplicationFiled: March 16, 2005Publication date: October 2, 2008Applicant: DAIICHI PURE CHEMICALS CO., LTDInventors: Yuriko Taniguchi, Tomohisa Nishio, Kazunori Saito
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Publication number: 20070178547Abstract: A method for measuring a glycated protein, a glycated peptide, or a glycated amino acid is provided. In this method, proteolytic activity of the protease is controlled to thereby realize high accuracy of the measurement. Also provided is a reagent used in such a measurement. More specifically, this invention provides a method of measuring a glycated protein, a glycated peptide, or a glycated amino acid comprising the steps of treating a sample containing the glycated protein with a protease for releasing a glycated peptide or a glycated amino acid; reacting the released glycated peptide or glycated amino acid with corresponding oxidase for generation of hydrogen peroxide; and measuring the resulting hydrogen peroxide with peroxidase and an oxidizable color developing reagent; wherein reaction solution before the reaction with the oxidase is adjusted to a pH of 1 to 5; and a reagent used in such measurement.Type: ApplicationFiled: March 16, 2005Publication date: August 2, 2007Applicant: Daiichi Pure Chemicals Co., Ltd.Inventors: Yuriko Taniguchi, Tomohisa Nishio, Kazunori Saito
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Publication number: 20070026523Abstract: Provided is a method for stabilizing a leuco dye, the method including storing a leuco dye in a solution in the co-presence of a protease protein.Type: ApplicationFiled: July 25, 2006Publication date: February 1, 2007Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Yuriko Taniguchi, Tomohisa Nishio, Koji Ushizawa