Patents by Inventor Tomokazu SHIBUYA

Tomokazu SHIBUYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11360078
    Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: June 14, 2022
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
  • Patent number: 10941374
    Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: March 9, 2021
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
  • Patent number: 10786812
    Abstract: Provided are a medical analysis device and a cell analysis method which can capture many cancer cells, including cancer cells not expressing EpCAM. The medical analysis device includes a flow channel zone, and also includes a chamber zone. The inner surface of the flow channel zone is at least partially provided with a layer of a hydrophilic polymer having a thickness of 2 to 200 nm.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: September 29, 2020
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
  • Publication number: 20200225212
    Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.
    Type: Application
    Filed: March 25, 2020
    Publication date: July 16, 2020
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
  • Patent number: 10641760
    Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: May 5, 2020
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
  • Patent number: 10620186
    Abstract: The present invention provides a method for capturing cancer cells which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a method for capturing cancer cells present in biological fluid, the method including reducing the protein level of sampled biological fluid, followed by capturing cancer cells using a hydrophilic polymer layer.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: April 14, 2020
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
  • Patent number: 10618996
    Abstract: Provided are methods for surface-modifying a thermoplastic resin which produce surfaces that show not only low adsorption of proteins and cells but also selective adsorption or adhesion of specific cells such as cancer cells, and further have excellent durability. A method for surface-modifying an object made of a thermoplastic resin, the method including: step 1 of forming polymerization initiation points on the surface of the object; and step 2 of radically polymerizing at least a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm to form a graft layer having a thickness of 2 to 100 nm on the surface of the object.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: April 14, 2020
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
  • Publication number: 20180088106
    Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.
    Type: Application
    Filed: August 31, 2017
    Publication date: March 29, 2018
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
  • Publication number: 20180088105
    Abstract: The present invention provides a method for capturing cancer cells which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a method for capturing cancer cells present in biological fluid, the method including reducing the protein level of sampled biological fluid, followed by capturing cancer cells using a hydrophilic polymer layer.
    Type: Application
    Filed: August 31, 2017
    Publication date: March 29, 2018
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
  • Publication number: 20180087017
    Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 29, 2018
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
  • Publication number: 20170320990
    Abstract: Provided are methods for surface-modifying a thermoplastic resin which produce surfaces that show not only low adsorption of proteins and cells but also selective adsorption or adhesion of specific cells such as cancer cells, and further have excellent durability. A method for surface-modifying an object made of a thermoplastic resin, the method including: step 1 of forming polymerization initiation points on the surface of the object; and step 2 of radically polymerizing at least a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm to form a graft layer having a thickness of 2 to 100 nm on the surface of the object.
    Type: Application
    Filed: April 24, 2017
    Publication date: November 9, 2017
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
  • Publication number: 20170320056
    Abstract: Provided are a medical analysis device and a cell analysis method which can capture many cancer cells, including cancer cells not expressing EpCAM. A medical analysis device including a flow channel zone that includes a chamber zone, the inner surface of the flow channel zone being at least partially provided with a layer of a hydrophilic polymer having a thickness of 2 to 200 nm.
    Type: Application
    Filed: April 24, 2017
    Publication date: November 9, 2017
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY
    Inventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA