Patents by Inventor Tomokazu SHIBUYA
Tomokazu SHIBUYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11360078Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.Type: GrantFiled: March 25, 2020Date of Patent: June 14, 2022Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Patent number: 10941374Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.Type: GrantFiled: September 1, 2017Date of Patent: March 9, 2021Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Patent number: 10786812Abstract: Provided are a medical analysis device and a cell analysis method which can capture many cancer cells, including cancer cells not expressing EpCAM. The medical analysis device includes a flow channel zone, and also includes a chamber zone. The inner surface of the flow channel zone is at least partially provided with a layer of a hydrophilic polymer having a thickness of 2 to 200 nm.Type: GrantFiled: April 24, 2017Date of Patent: September 29, 2020Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Publication number: 20200225212Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.Type: ApplicationFiled: March 25, 2020Publication date: July 16, 2020Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
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Patent number: 10641760Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.Type: GrantFiled: August 31, 2017Date of Patent: May 5, 2020Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Patent number: 10620186Abstract: The present invention provides a method for capturing cancer cells which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a method for capturing cancer cells present in biological fluid, the method including reducing the protein level of sampled biological fluid, followed by capturing cancer cells using a hydrophilic polymer layer.Type: GrantFiled: August 31, 2017Date of Patent: April 14, 2020Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Patent number: 10618996Abstract: Provided are methods for surface-modifying a thermoplastic resin which produce surfaces that show not only low adsorption of proteins and cells but also selective adsorption or adhesion of specific cells such as cancer cells, and further have excellent durability. A method for surface-modifying an object made of a thermoplastic resin, the method including: step 1 of forming polymerization initiation points on the surface of the object; and step 2 of radically polymerizing at least a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm to form a graft layer having a thickness of 2 to 100 nm on the surface of the object.Type: GrantFiled: April 24, 2017Date of Patent: April 14, 2020Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Publication number: 20180088106Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.Type: ApplicationFiled: August 31, 2017Publication date: March 29, 2018Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
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Publication number: 20180088105Abstract: The present invention provides a method for capturing cancer cells which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a method for capturing cancer cells present in biological fluid, the method including reducing the protein level of sampled biological fluid, followed by capturing cancer cells using a hydrophilic polymer layer.Type: ApplicationFiled: August 31, 2017Publication date: March 29, 2018Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
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Publication number: 20180087017Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.Type: ApplicationFiled: September 1, 2017Publication date: March 29, 2018Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
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Publication number: 20170320990Abstract: Provided are methods for surface-modifying a thermoplastic resin which produce surfaces that show not only low adsorption of proteins and cells but also selective adsorption or adhesion of specific cells such as cancer cells, and further have excellent durability. A method for surface-modifying an object made of a thermoplastic resin, the method including: step 1 of forming polymerization initiation points on the surface of the object; and step 2 of radically polymerizing at least a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm to form a graft layer having a thickness of 2 to 100 nm on the surface of the object.Type: ApplicationFiled: April 24, 2017Publication date: November 9, 2017Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA
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Publication number: 20170320056Abstract: Provided are a medical analysis device and a cell analysis method which can capture many cancer cells, including cancer cells not expressing EpCAM. A medical analysis device including a flow channel zone that includes a chamber zone, the inner surface of the flow channel zone being at least partially provided with a layer of a hydrophilic polymer having a thickness of 2 to 200 nm.Type: ApplicationFiled: April 24, 2017Publication date: November 9, 2017Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takashi HOSHIBA, Tomokazu SHIBUYA