Abstract: The present invention provides a therapeutic agent for an immune/inflammatory disease comprising an anti-human TIGIT antibody, which activates a suppressive immune checkpoint molecule (TIGIT), as an active ingredient. Also, provided is an antibody having the following characteristics a) and b): a) the third CDR of heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 4 b) the third CDR of light chain variable region comprises the amino acid sequence of SEQ ID NO: 6.

Abstract: Antibodies, fragments thereof and fusion proteins that specifically bind to Clec12A, are described, as well as methods of making and using such antibodies. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various autoimmune diseases and cancers, including leukemia, lymphoma, or myeloma, including, for example, acute myeloid leukemia.

Abstract: In order to provide a circuit which can realize high-speed frequency tracking performance while satisfying jitter/wander suppression performance, the circuit controls loop gain of a PLL means, which extracts a clock signal of a SDH signal or an Ethernet signal from an OTN signal, on the basis of a result of processing a jitter/wander component and a frequency change state on the basis of phase comparison data of the PLL means.

Abstract: A polarization multiplexing optical receiver according to the invention includes a polarization splitting unit receiving polarization multiplexed lights which are modulated according to a first input signal and a second input signal including respective identifier, and splitting the polarization multiplexed light into a first polarized received light and a second polarized received light, a pair of photoelectric conversion units, a demodulation unit performing symbol recognition about the first received signal and the second received signal, and outputting a first demodulated signal and a second demodulated signal, an identifier detecting unit detecting the identifiers from the first demodulated signal and the second demodulated signal, and a delay compensation unit calculating a delay difference between the first demodulated signal and the second demodulated signal based on the identifiers, and inserting delay time corresponding to the delay difference into the first demodulated signal or the second demodula

Abstract: In order to provide a circuit which can realize high-speed frequency tracking performance while satisfying jitter/wander suppression performance, the circuit controls loop gain of a PLL means, which extracts a clock signal of a SDH signal or an Ethernet signal from an OTN signal, on the basis of a result of processing a jitter/wander component and a frequency change state on the basis of phase comparison data of the PLL means.

Abstract: A polarization multiplexing optical receiver according to the invention includes a polarization splitting unit receiving polarization multiplexed lights which are modulated according to a first input signal and a second input signal including respective identifier, and splitting the polarization multiplexed light into a first polarized received light and a second polarized received light, a pair of photoelectric conversion units, a demodulation unit performing symbol recognition about the first received signal and the second received signal, and outputting a first demodulated signal and a second demodulated signal, an identifier detecting unit detecting the identifiers from the first demodulated signal and the second demodulated signal, and a delay compensation unit calculating a delay difference between the first demodulated signal and the second demodulated signal based on the identifiers, and inserting delay time corresponding to the delay difference into the first demodulated signal or the second demodula