Patents by Inventor Tomomichi Futo
Tomomichi Futo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180243422Abstract: The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic polymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably releases compound (I) or a salt thereof over a long period of time and exerts medicinal effects of compound (I) or a salt thereof over a long period of time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing frequency of administration, is an excellent formulation as a clinical medicine.Type: ApplicationFiled: October 19, 2017Publication date: August 30, 2018Inventors: Tomomichi FUTO, Hikaru TAIRA, Seitaro MIZUKAMI, Naoyuki MURATA
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Publication number: 20180228732Abstract: The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic acid-glycolic acid copolymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably release compound (I) or a salt thereof for a long time and exerts a medicinal effect of compound (1) or a salt thereof for a long time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing the number of administration times, is an excellent formulation as a clinical medicine.Type: ApplicationFiled: November 10, 2017Publication date: August 16, 2018Inventors: Tomomichi FUTO, Hikaru TAIRA, Seitaro MIZUKAMI, Naoyuki MURATA
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Patent number: 9713595Abstract: Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.Type: GrantFiled: February 28, 2017Date of Patent: July 25, 2017Assignee: Takeda Pharmaceuticals Company LimitedInventors: Tomomichi Futo, Kazuhiro Saito, Tetsuo Hoshino, Masuhisa Hori
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Publication number: 20170165204Abstract: Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.Type: ApplicationFiled: February 28, 2017Publication date: June 15, 2017Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomomichi FUTO, Kazuhiro SAITO, Tetsuo HOSHINO, Masuhisa HORI
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Patent number: 9617303Abstract: Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.Type: GrantFiled: November 19, 2014Date of Patent: April 11, 2017Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomichi Futo, Kazuhiro Saito, Tetsuo Hoshino, Masuhisa Hori
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Publication number: 20150080322Abstract: Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.Type: ApplicationFiled: November 19, 2014Publication date: March 19, 2015Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomomichi Futo, Kazuhiro Saito, Tetsuo Hoshino, Masuhisa Hori
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Patent number: 8927016Abstract: This invention provides a production method for a solid sustained-release preparation, characterized in that a sustained-release preparation (a sustained-release preparation suspension) is freeze-dried in a freeze-drying container whose inner face is partially or totally coated with an ice layer or water-repelling base material.Type: GrantFiled: November 23, 2010Date of Patent: January 6, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Hisayoshi Shimizu, Muneo Nonomura, Tomomichi Futo, Kei Mukai
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Patent number: 8921326Abstract: Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.Type: GrantFiled: December 17, 2007Date of Patent: December 30, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomichi Futo, Kazuhiro Saito, Tetsuo Hoshino, Masuhisa Hori
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Publication number: 20130210742Abstract: The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic polymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably releases compound (I) or a salt thereof over a long period of time and exerts medicinal effects of compound (I) or a salt thereof over a long period of time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing frequency of administration, is an excellent formulation as a clinical medicine.Type: ApplicationFiled: June 23, 2011Publication date: August 15, 2013Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomomichi Futo, Hikaru Taira, Seitaro Mizukami, Naoyuki Murata
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Publication number: 20120302508Abstract: The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic acid-glycolic acid copolymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably release compound (I) or a salt thereof for a long time and exerts a medicinal effect of compound (I) or a salt thereof for a long time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing the number of administration times, is an excellent formulation as a clinical medicine.Type: ApplicationFiled: December 21, 2010Publication date: November 29, 2012Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomomichi Futo, Hikaru Taira, Seitaro Mizukami, Naoyuki Murata
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Publication number: 20110135741Abstract: Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.Type: ApplicationFiled: December 17, 2007Publication date: June 9, 2011Inventors: Tomomichi Futo, Kazuhiro Saito, Tetsuo Hoshino, Masuhisa Hori
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Publication number: 20110070311Abstract: This invention provides a production method for a solid sustained-release preparation, characterized in that a sustained-release preparation (a sustained-release preparation suspension) is freeze-dried in a freeze-drying container whose inner face is partially or totally coated with an ice layer or water-repelling base material.Type: ApplicationFiled: November 23, 2010Publication date: March 24, 2011Inventors: Hisayoshi Shimizu, Muneo Nonomura, Tomomichi Futo, Kei Mukai
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Publication number: 20100331357Abstract: The present invention provides a pharmaceutical composition, wherein solubility and stability of a water-insoluble or slightly water-soluble compound represented by formula (I): wherein each symbol is as defined in the specification, are improved, by combination of the above-mentioned compound and a cyclodextrin derivative and a method for improving solubility, stability and the like of the above-mentioned compound.Type: ApplicationFiled: February 27, 2009Publication date: December 30, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Tomomichi Futo, Shinichiro Nakai, Rinaldo Laurentius De Jong, Bumsup Lee, Ronald Joseph Christopher
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Patent number: 7662408Abstract: A sustained release preparation comprising a combination of a microcapsule which gradually releases a GnRH agonist or a salt thereof for a long term, and a microcapsule which gradually releases a GnRH agonist or a salt thereof for a short term.Type: GrantFiled: February 9, 2005Date of Patent: February 16, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Kazuhiro Saito, Tomomichi Futo, Tetsuo Hoshino
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Publication number: 20080118545Abstract: A sustained-release composition which comprises (i) a physiologically active substance and (ii) a lactic acid-glycolic acid copolymer in which the weight-average molecular weight (Mw) is about 8,000 to about 11,500, the ratio of the weight-average molecular weight (Mw) to the number-average molecular weight (Mn) is greater than 1.9, and the compositional molar ratio of lactic acid to glycolic acid is 99.9/0.1 to 60/40, or a salt thereof, and which does not contain a drug retaining substance is provided and said sustained-release composition has improved spherical property and/or needle penetrating property.Type: ApplicationFiled: June 30, 2005Publication date: May 22, 2008Inventors: Tomomichi Futo, Kei Mukai, Jiichi Arai
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Publication number: 20060074027Abstract: A sustained release preparation comprising a combination of a microcapsule which gradually releases a GnRH agonist or a salt thereof for a long term, and a microcapsule which gradually releases a GnRH agonist or a salt thereof for a short term.Type: ApplicationFiled: February 9, 2005Publication date: April 6, 2006Inventors: Kazuhiro Saito, Tomomichi Futo, Tetsuo Hoshino
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Publication number: 20050100604Abstract: This invention provides a production method for a solid sustained-release preparation, characterized in that a sustained-release preparation (a sustained-release preparation suspension) is freeze-dried in a freeze-drying container whose inner face is partially or totally coated with an ice layer or water-repelling base material.Type: ApplicationFiled: December 2, 2004Publication date: May 12, 2005Inventors: Hisayoshi Shimizu, Muneo Nonomura, Tomomichi Futo, Kei Mukai
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Publication number: 20050064039Abstract: A provision of a method for producing a microsphere improved in dispersibility. A method for producing a microsphere improved in dispersibility, characterized in that during the production of microspheres by an in-water drying method, an osmotic pressure regulating agent is added to an outer water phase.Type: ApplicationFiled: December 25, 2002Publication date: March 24, 2005Inventors: Tomomichi Futo, Kazumichi Yamamoto, Jiichi Arai
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Patent number: 6083916Abstract: A drug comprising either a peptide having the LH-RH action or an LH-RH antagonist is carried on an intrauterine contraceptive device (IUD) so as to be able to provide controlled release. Once the IUD is put in the uterus, the carried drug is gradually released over such a prolonged period of treatment time as, for example, several months to be continuously absorbed through the uterus mucosa or the vagina mucosa. This construction makes it possible to reduce the patient's pain and such a troublesomeness as frequent drug administration and continuously administer a necessary drug over a prolonged period of time while taking a contraceptive measures.Type: GrantFiled: March 30, 1998Date of Patent: July 4, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Nonomura, Tomomichi Futo, Hisayoshi Shimizu
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Patent number: 5611971Abstract: There is provided a process for producing microcapsules of a water-soluble drug by in-water drying process, which comprises carrying out the process in the presence of an osmotic pressure adjustor present in the external aqueous phase. This process improves the drug take up into microcapsules.Type: GrantFiled: August 6, 1993Date of Patent: March 18, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Koichi Maedera, Masuhisa Hori, Tomomichi Futo