Abstract: A brake device includes a brake pedal, an input rod, a master cylinder, a guide rail, a slider, and a coupling arm. The brake pedal is rotatable using an arm rotary shaft disposed on one end of a pedal arm used as a fulcrum. A pedal force input to the brake pedal is transmitted to the input rod as a thrust. The master cylinder is configured to generate a brake hydraulic pressure responsive to the thrust input to the input rod. The guide rail is disposed on the pedal arm and extends along a longitudinal direction of the pedal arm. The slider is coupled to the pedal arm via the guide rail and is movable on the guide rail. The coupling arm has a first end rotatably coupled to the slider and a second end rotatably coupled to the input rod. The second end is different from the first end.

Abstract: To provide a therapeutic agent for cancer having a higher therapeutic effect. A therapeutic agent for cancer, containing: at least one selected from the group consisting of curcumin and a derivative thereof; and at least one selected from the group consisting of an anti-PD-1 antibody, an anti-PD-L1 antibody, and an anti-PD-L2 antibody in combination.

Abstract: A brake device includes a brake pedal, an input rod, a master cylinder, a guide rail, a slider, and a coupling arm. The brake pedal is rotatable using an arm rotary shaft disposed on one end of a pedal arm used as a fulcrum. A pedal force input to the brake pedal is transmitted to the input rod as a thrust. The master cylinder is configured to generate a brake hydraulic pressure responsive to the thrust input to the input rod. The guide rail is disposed on the pedal arm and extends along a longitudinal direction of the pedal arm. The slider is coupled to the pedal arm via the guide rail and is movable on the guide rail. The coupling arm has a first end rotatably coupled to the slider and a second end rotatably coupled to the input rod. The second end is different from the first end.