Abstract: A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer is fed into the first through-hole, and a capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.

Abstract: A high-pressure tank configured to store a fluid includes: a liner; and a fiber-reinforced resin layer configured to cover surface of the liner. The liner includes: a cylindrical liner portion in a cylindrical shape; and dome liner portions in a dome shape, each dome liner portion being connected with the cylindrical liner portion, such that an outer surface of the dome liner portion is inclined at a predetermined angle to an outer surface of the cylindrical liner portion. The fiber-reinforced resin layer includes a hoop layer provided by hoop winding that winds the fiber substantially perpendicularly to a central axis of the cylindrical liner portion. The hoop layer is formed, such that an outer surface of the hoop layer has a smaller angle than the predetermined angle to the outer surface of the dome liner portion at a boundary between the hoop layer and the dome liner portion.

Abstract: An object of the present invention is to provide a method of measuring the amount of a compound containing a sugar chain in a biological sample by a sandwich immunoassay method using a labeled lectin, which method is suitable for reduction of noise originating from impurities and determination of the exact amount of a target compound. The present invention provides a method of measuring the amount of a target compound containing a sugar chain in a biological sample by a sandwich immunoassay method using a labeled lectin (including cases where a target compound-capturing substance other than an antibody is used as a ligand), the method containing adding a sugar chain compound which competes (crosses) with impurities contained in the biological sample in binding with the labeled lectin.

Abstract: The present invention provides a sandwich assay for quantifying a glycoprotein, which is a substance to be detected, in a sample using a labeled lectin, wherein the effect attributed to a contaminant, namely noise on the quantified value of the substance to be detected, is suppressed by introduction of a simple treatment. The sandwich assay includes a treatment for inhibiting the binding of the labeled lectin to a sugar chain carried by the contaminant non-specifically adsorbed to the measurement region, which contaminant is contained in the sample and which sugar chain is the same as that of the substance to be detected.

Abstract: A method of analyzing diagnostic information, the method including: measuring a concentration of a mucin-1 (Tn-MUC1), which is reactive with a lectin that recognizes and binds to an N-acetyl-D-galactosamine?serine (threonine) residue, in a blood sample originated from a subject to be diagnosed; comparing the measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of Tn-MUC1 is greater than the threshold value.

Abstract: A method of analyzing diagnostic information, the method including: measuring the concentration of all mucin-1s (total MUC1) in a blood sample originated from a subject to be diagnosed; comparing the measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of total MUC1 is greater than the threshold value.

Abstract: An object of the present invention is to provide a method of measuring the amount of a compound containing a sugar chain in a biological sample by a sandwich immunoassay method using a labeled lectin, which method is suitable for reduction of noise originating from impurities and determination of the exact amount of a target compound. The present invention provides a method of measuring the amount of a target compound containing a sugar chain in a biological sample by a sandwich immunoassay method using a labeled lectin (including cases where a target compound-capturing substance other than an antibody is used as a ligand), the method containing adding a sugar chain compound which competes (crosses) with impurities contained in the biological sample in binding with the labeled lectin.

Abstract: An object of the present invention is to provide a method of suppressing, in an immunoassay using surface plasmon-field enhanced fluorescence spectroscopy (SPFS), nonspecific signals generated by nonspecific adsorption of contaminants contained in a sample to an SPFS sensor section (e.g., a primary antibody, a solid-phase layer and a metal thin film). The present invention relates to a method of suppressing nonspecific signals originating from contaminants in an immunoassay using surface plasmon-field enhanced fluorescence spectroscopy (SPFS) (including cases where a receptor for a compound to be measured is used in place of a primary antibody), the method comprising performing at least one of the following pretreatments: (1) a pretreatment of adding an acid or an alkali to a sample; (2) a pretreatment of adding a metal ion to the sample; and (3) a pretreatment of heating the sample.

Abstract: The present invention provides a method by which lung squamous cell carcinoma can be detected in a simple and prompt manner with high detection performance; and the like. The method according to the present invention detects lung squamous cell carcinoma by an assessment including the steps of: (1) performing measurement of the desmoglein 3 content in a blood sample collected from a subject; and (2) comparing the desmoglein 3 content determined by the measurement with the desmoglein 3 content in a blood sample collected from a healthy individual so as to estimate the presence of lung squamous cell carcinoma in the subject when the desmoglein 3 content is higher in the blood sample collected from the subject.

Abstract: The present invention relates to variant SH2 domains for binding a phosphotyrosine (pTyr)-containing peptide. The variant SH2 domains of the present invention include a parent SH2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent SR2 domain, wherein said at least one amino acid substitution increases the affinity of the variant SH2 domain for the pTyr-containing peptide relative to the parent SH2 domain. The present application relates also to methods of using the variant SH2 domains in the treatment of protein kinase-associated disorders, or the diagnosis or prognosis of protein kinase-associated disorders, for isolating and measuring the concentration of pTyr-containing molecules, and as reagents in research.

Abstract: An antigen detection method detects an antigen having a specific sugar chain in a sample with a lectin that binds to plural kinds of sugar chains including the specific sugar chain. The detection method includes: a first step of bringing the lectin into contact with the sample; a second step of bringing a glycohydrolase capable of cleaving at least one kind of sugar chain to which the lectin can bind into contact with the sample, the at least one kind of sugar chain excluding the specific sugar chain among the plural kinds of sugar chains; and a step of detecting the antigen bound with the lectin after the first and second steps.

Abstract: [Problem] An object of the present invention is to provide a method by which the amount of a very small amount of analyte (in particular, one having a sugar chain) can be measured with a high accuracy and a device which is used for said measurement method. [Means for Solution] The method for measuring the amount of an analyte according to the present invention is characterized in that a lectin labeled with a fluorescent dye, preferably said lectin whose dissociation rate constant [kd] is from 1.0×10?6 to 1.0×10?3 (S?1), is used as a secondary antibody in a sandwich assay using a surface plasmon excitation enhanced fluorescence spectroscopy [SPFS; Surface Plasmon-field enhanced Fluorescence Spectroscopy].

Abstract: A high-pressure tank configured to store a fluid includes: a liner; and a fiber-reinforced resin layer configured to include a fiber and to cover surface of the liner. The liner includes: a cylindrical liner portion in a cylindrical shape; and dome liner portions in a dome shape connected with respective sides of the cylindrical liner portion, each dome liner portion being connected with the cylindrical liner portion, such that an outer surface of the dome liner portion is inclined at a predetermined angle to an outer surface of the cylindrical liner portion. The fiber-reinforced, resin layer includes a hoop layer formed on the outer surface of the cylindrical liner portion to cover the outer surface of the cylindrical liner portion and provided by hoop winding that winds the fiber substantially perpendicularly to a central axis of the cylindrical liner portion.

Abstract: This invention relates to grease compositions containing mineral oil and/or synthetic oil as base oil, (A) lithium stearate as thickener, and (B) one kind or two kinds of more of compounds selected from a group of oxidized paraffins and diphenyl hydrogenphosphite and displaying a worked penetration in the range 270-350 and also to bearings such a s linear guides, ball screws, and rolling bearings sealed with said grease compositions. This invention can provide grease compositions of low dust emission which perform with an excellent balance of low dust emission, low rolling characteristics and fretting resistance, extend the lubricating period, reduce the maintenance cost, and are suitable for use in a clean environment. This invention can also provide bearings sealed with said grease compositions of low dust emission suitable for use in a clean environment such as semiconductor manufacturing equipment, liquid crystal manufacturing equipment, and electronic computers.

Abstract: Method and apparatus for controlling the cooling of a hermetic type control box accommodating therein electronic apparatus by means of a cooling system. A cooling member of the cooling system is disposed at an upper portion of a hermetically closed chamber in which the electronic apparatus is housed. On the basis of measurements of intra-box temperature and extra-box temperature, control is so performed that the intra-box temperature is maintained higher than the extra-box temperature by a predetermined value when the cooling is being effected within the control box by means of the cooling system.