Abstract: This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.

Abstract: An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

Abstract: An apparatus includes a first roll and a second roll on each of which a pattern is formed, a first motor and a second motor to rotate the respective rolls, a shaft direction supporting mechanism to support the second roll along a shaft direction and an axial position adjusting mechanism configured to move the shaft direction supporting mechanism along the shaft direction. The posture of the rotating shaft of the second motor is maintained constant at all times, and the second roll is moved in the shaft direction along the first roll, thereby adjusting the positions of both patterns on the first roll and the second roll along the shaft direction.

Abstract: An apparatus includes a first roll and a second roll on each of which a pattern is formed, a first motor and a second motor to rotate the respective rolls, a shaft direction supporting mechanism to support the second roll along a shaft direction and an axial position adjusting mechanism configured to move the shaft direction supporting mechanism along the shaft direction. The posture of the rotating shaft of the second motor is maintained constant at all times, and the second roll is moved in the shaft direction along the first roll, thereby adjusting the positions of both patterns on the first roll and the second roll along the shaft direction.

Abstract: An apparatus includes a first roll and a second roll on each of which a pattern is formed, a first motor and a second motor to rotate the respective rolls, a shaft direction supporting mechanism to support the second roll along a shaft direction and an axial position adjusting mechanism configured to move the shaft direction supporting mechanism along the shaft direction. The posture of the rotating shaft of the second motor is maintained constant at all times, and the second roll is moved in the shaft direction along the first roll, thereby adjusting the positions of both patterns on the first roll and the second roll along the shaft direction.

Abstract: It is intended to provide a novel compound having high antitumor activity and low toxicity to normal cells.

Abstract: A thin film member forming device includes a reference roll fixedly disposed while being rotatably supported by a first bearing member, a movable roll disposed movably with respect to the reference roll while being rotatably supported by a second bearing member, a roll gap adjusting mechanism which adjusts a gap between the reference roll and the movable roll and a roll opening mechanism which expands the gap. The roll gap adjusting mechanism adds a load in a direction to narrow the gap to the second bearing member, and the roll opening mechanism adds a load in a direction to expand the gap to the second bearing member.

Abstract: It is intended to provide a novel compound having high antitumor activity and low toxicity to normal cells.

Abstract: On at least the edge portion (9e) of the lip portion (9) of a T-die (1), a cladding layer (10) is provided. The cladding layer is formed by laser build-up welding to a base material with a powder of a corrosion resistant and wear resistant alloy comprising a nickel-based alloy or a cobalt-based alloy. The cladding layer has a metallographic structure in which metal borides are dispersed in a binder phase. The lip portion has high quality and has high durability. The manufacturing costs of the T-die can also be kept relatively low.

Abstract: An apparatus includes a first roll and a second roll on each of which a pattern is formed, a first motor and a second motor to rotate the respective rolls, a shaft direction supporting mechanism to support the second roll along a shaft direction and an axial position adjusting mechanism configured to move the shaft direction supporting mechanism along the shaft direction. The posture of the rotating shaft of the second motor is maintained constant at all times, and the second roll is moved in the shaft direction along the first roll, thereby adjusting the positions of both patterns on the first roll and the second roll along the shaft direction.

Abstract: A thin film member forming device includes a reference roll fixedly disposed while being rotatably supported by a first bearing member, a movable roll disposed movably with respect to the reference roll while being rotatably supported by a second bearing member, a roll gap adjusting mechanism which adjusts a gap between the reference roll and the movable roll and a roll opening mechanism which expands the gap. The roll gap adjusting mechanism adds a load in a direction to narrow the gap to the second bearing member, and the roll opening mechanism adds a load in a direction to expand the gap to the second bearing member.

Abstract: According to one embodiment, a rotating state of a second motor is transmitted to a second roll as it is. A posture of a rotation central axis of the second motor is maintained constant. A changed state of the second roll is not transmitted to the second motor. Thereby, the second roll is rotated with timing identical to the rotating state of the second motor.

Abstract: On at least the edge portion (9e) of the lip portion (9) of a T-die (1), a cladding layer (10) is provided. The cladding layer is formed by laser build-up welding to a base material with a powder of a corrosion resistant and wear resistant alloy comprising a nickel-based alloy or a cobalt-based alloy. The cladding layer has a metallographic structure in which metal borides are dispersed in a binder phase. The lip portion has high quality and has high durability. The manufacturing costs of the T-die can also be kept relatively low.

Abstract: On at least the edge portion (9e) of the lip portion (9) of a T-die (1), a cladding layer (10) is provided. The cladding layer is formed by laser build-up welding to a base material with a powder of a corrosion resistant and wear resistant alloy comprising a nickel-based alloy or a cobalt-based alloy. The cladding layer has a metallographic structure in which metal borides are dispersed in a binder phase. The lip portion has high quality and has high durability. The manufacturing costs of the T-die can also be kept relatively low.

Abstract: An sheet forming apparatus selectively uses two control modes: a constant roller gap control mode where a roller gap is controlled by a roller gap adjustment means so that the roller gap converges a predetermined control target value; and a constant pressing load control mode where the roller gap is controlled by the roller adjustment means so that a pressing load converges a predetermined control target value.

Abstract: An sheet forming apparatus selectively uses two control modes: a constant roller gap control mode where a roller gap is controlled by a roller gap adjustment means so that the roller gap converges a predetermined control target value; and a constant pressing load control mode where the roller gap is controlled by the roller adjustment means so that a pressing load converges a predetermined control target value.