Abstract: Cyclic compounds and oligopeptide compounds that selectively inhibit KRAS were found. Oligopeptide compounds and non-natural amino acids useful for producing a cyclic compound were also found. Moreover, cyclic compounds and oligopeptide compounds were found to interact with an amino acid residue specific to KRAS.

Abstract: In at least some implementations, a charge forming device includes a main body having a throttle bore, a throttle valve, a housing and a circuit board including a throttle position sensor and a pressure sensor. The throttle valve is received at least partially within the valve bore, is rotatable between an idle position and a second position, and includes a magnet that is rotated when the throttle valve rotates. The housing is carried by the main body, and the circuit board is carried by the housing. A signal path is defined leading from the pressure sensor to a pressure source, the signal path includes a liquid collection area located below a gaseous area with respect to gravity.

Abstract: In at least some implementations, a fuel metering valve, includes a bobbin defining a passage and having one or more voids in the surface of the bobbin that defines the passage, aa wire coil around the bobbin and an armature. The armature is received within the passage in the bobbin and movable relative to the bobbin from a first position to a second position when electricity is supplied to the wire coil.

Abstract: In at least some implementations, a fuel metering valve, includes a bobbin defining a passage and having one or more voids in the surface of the bobbin that defines the passage, aa wire coil around the bobbin and an armature. The armature is received within the passage in the bobbin and movable relative to the bobbin from a first position to a second position when electricity is supplied to the wire coil.

Abstract: In at least some implementations, a charge forming device for a combustion engine includes a throttle body and a throttle valve. The throttle body has a throttle bore with an inlet through which air flows into the throttle bore and an outlet from which a fuel and air mixture exits the throttle bore. The throttle bore has a throat between the inlet and outlet and the throat has a reduced flow area compared to at least one of the inlet and outlet. The throttle valve has a valve head received within the throat of the throttle bore and movable relative to the throttle body between a first position and a second position wherein the flow area between the valve head and the throttle body is greater when the valve head is in the second position than in the first position.

Abstract: In at least some implementations, a charge forming system for a combustion engine includes a first fuel supply device having a first passage from which fuel is discharged for delivery to the engine and a second fuel supply device having a second passage from which fuel is discharged for delivery to the engine. The first passage communicates with the second passage so that the fuel in the first passage is combined with the fuel in the second passage.

Abstract: In at least some implementations, a charge forming system for a combustion engine includes a first fuel supply device having a first passage from which fuel is discharged for delivery to the engine and a second fuel supply device having a second passage from which fuel is discharged for delivery to the engine. The first passage communicates with the second passage so that the fuel in the first passage is combined with the fuel in the second passage.

Abstract: A charge forming device includes a body with a main bore through which air flows and a fuel inlet through which fuel enters the main bore. A diaphragm defines part of a fuel chamber that leads to a fuel passage. The valve body is received in the fuel passage and has a first end, a second end, a sidewall, a valve passage having an inlet into which fuel from the fuel chamber enters and an outlet from which fuel exits for delivery to the main bore, and a cross passage extending through the sidewall between the first end and the second end and opening into the valve passage. A valve is carried by the body and has a valve head received in the cross passage and extending into the valve passage to at least partially inhibit fuel flow through the valve passage.

Abstract: In at least some implementations, a charge forming device for a combustion engine includes a throttle body and a throttle valve. The throttle body has a throttle bore with an inlet through which air flows into the throttle bore and an outlet from which a fuel and air mixture exits the throttle bore. The throttle bore has a throat between the inlet and outlet and the throat has a reduced flow area compared to at least one of the inlet and outlet. The throttle valve has a valve head received within the throat of the throttle bore and movable relative to the throttle body between a first position and a second position wherein the flow area between the valve head and the throttle body is greater when the valve head is in the second position than in the first position.

Abstract: A charge forming device includes a body with a main bore through which air flows and a fuel inlet through which fuel enters the main bore. A diaphragm defines part of a fuel chamber that leads to a fuel passage. The valve body is received in the fuel passage and has a first end, a second end, a sidewall, a valve passage having an inlet into which fuel from the fuel chamber enters and an outlet from which fuel exits for delivery to the main bore, and a cross passage extending through the sidewall between the first end and the second end and opening into the valve passage. A valve is carried by the body and has a valve head received in the cross passage and extending into the valve passage to at least partially inhibit fuel flow through the valve passage.

Abstract: In at least some implementations, a fuel supply device includes a body assembly having a main bore from which fuel is supplied, an inlet passage, a valve seat adjacent to the inlet passage and a fuel chamber communicated with the main bore and with the inlet passage to receive a supply of fuel from the inlet passage, and an inlet valve carried by the body assembly. The inlet valve has a valve head with a body and an engagement portion extending outwardly from the body. The inlet valve is movable relative to the valve seat from an open position in which the engagement portion is spaced from the valve seat and fuel from the inlet passage may flow through the valve seat and into the fuel chamber and a closed position in which the engagement portion is engaged with the valve seat.

Abstract: In at least some implementations, a pressure regulator includes a first body, a second body coupled to the first body and a diaphragm having a portion trapped between the first body and the second body and a not trapped portion that is movable relative to the first body and second body. A stop surface is defined by the second body, and a backing member is coupled to the not trapped portion of the diaphragm for movement with the not trapped portion of the diaphragm. The backing member engages the stop surface to limit the amount the not trapped portion of the diaphragm can move toward the second body.