Abstract: The present invention provides a method of screening method small-molecule candidate therapeutics capable of inhibiting or interfering with intracellular protein-protein interactions, such as cancer associated oncogenic protein interactions and in particular RAS and LMO2 protein-protein interactions. The present invention also provides methods and assays for rationalized drug design based on identifying small molecular weight protein-protein interaction inhibitor molecules that emulate antibody therapeutics products.

Abstract: On a seat base (11) of a floor member (10), a rear surface plate (11C), an operator's seat mounting plate (11D) on which an operator's seat (17) is mounted at a position higher than a footrest area (12) on which the foot is placed, and a duct accommodating space (14) formed in the vertical direction among the rear surface plate (11C), the operator's seat mounting plate (11D), and a rear position (12B) of the footrest area (12) are provided. An indoor air inlet duct (23) having the front surface side opened as a filter fitting hole (25) and introducing air in an occupying space (21) toward an indoor unit (22) of an air-conditioning unit is provided on the duct accommodating space (14). An indoor air filter (26) for catching dusts in the air is provided on the filter fitting hole (25) of the indoor air inlet duct (23).

Abstract: A canopy (23) is provided to rise in an upper revolving structure (3) for covering an upper side of an operator's seat (19). A bend portion (25B) extending in the left-right direction and projecting upward is provided in a front end side of a roof plate (25) in the canopy (23). A plate-shaped left front lifting bracket (26) is provided in a left front connecting portion (24J), and a plate-shaped right front lifting bracket (27) is provided in a right front connecting portion (24L). The left and right front lifting brackets (26, 27) sandwich the bend portion (25B) from both sides in the left-right direction. Further, the left and right front lifting brackets (26, 27) are provided with lifting holes (26A, 27A) and also discharging notches (26B, 27B).

Abstract: A method of manufacturing a spark plug includes a joining step of joining a first member and a second member which constitute the spark plug. In the joining step, a first welding electrode in contact with the first member and a second welding electrode which has an elastically deformable intermediate portion and which is in contact with the second member are electrically connected through the first member and the second member, whereby the first member and the second member are joined together by resistance welding.

Abstract: A floor member is formed by a seat support platform on a rear side and a footrest area located on a front side of the seat support platform, and a cab box is formed by a front panel, a rear panel, a left front side panel, a left rear side panel, a right side panel, and a top panel. A right reinforcing panel is provided at a right side position of the floor member and rises upwardly of the footrest area. The right side panel of the cab box corresponding to this right reinforcing panel is provided with a notched portion for avoiding interference with the right reinforcing panel. Accordingly, since the strength at the right side position of the floor member can be enhanced by the right reinforcing panel, it is possible to prevent deformation such as torsion and distortion when the floor member is tilted up.

Abstract: An entrance way is provided on a left front surface surrounded by the left front pillar, the left intermediate pillar, and the left front roof pillar of the cab box, and a door for opening/closing this entrance way is mounted rotatably on a left intermediate pillar. A seal member for sealing the entire periphery of the cab box when the door is closed is provided in the periphery of the door. On the lower side of the left front roof pillar, a seal receiving member is provided separately from the left front roof pillar, and this seal receiving member forms a seal receiving surface with which an upper seal portion extending in the front-rear direction at an upper side position of the seal member is brought into contact when the door is closed.

Abstract: A cab (8) is provided with a cab box (13) in which a space between each of pillars (14 to 18) is covered by each of surfaces (13A to 13F) and the inside becomes an operator's room (13G) and a door (24) mounted on the left intermediate pillar (16). On a rear surface portion (14D) of the left front pillar (14), a protruding portion (23A1) of a mounting plate (23A) is provided in a state protruding to the door (24) side. On a mounting opening (24E) on the inner surface side of the door (24), a door holding member (28) engaged with an engaging member (23) and holding the door (24) at a closed position is provided. On the door (24), a retreating recessed portion (29) for avoiding interference with the protruding portion (23A1) of the mounting plate (23A) is provided on the front side from the door holding member (28).

Abstract: A canopy (23) is provided to rise in an upper revolving structure (3) for covering an upper side of an operator's seat (19). A bend portion (25B) extending in the left-right direction and projecting upward is provided in a front end side of a roof plate (25) in the canopy (23). A plate-shaped left front lifting bracket (26) is provided in a left front connecting portion (24J), and a plate-shaped right front lifting bracket (27) is provided in a right front connecting portion (24L). The left and right front lifting brackets (26, 27) sandwich the bend portion (25B) from both sides in the left-right direction. Further, the left and right front lifting brackets (26, 27) are provided with lifting holes (26A, 27A) and also discharging notches (26B, 27B).

Abstract: A method of manufacturing a spark plug includes a joining step of joining a first member and a second member which constitute the spark plug. In the joining step, a first welding electrode in contact with the first member and a second welding electrode which has an elastically deformable intermediate portion and which is in contact with the second member are electrically connected through the first member and the second member, whereby the first member and the second member are joined together by resistance welding.

Abstract: An upper revolving structure (3) includes a revolving frame (5), a floor member (9) which is provided on the revolving frame (5) and a front side of which serves as a footrest section (11) on which an operator rests his or her feet, a cab box (17) which forms an operating room (18) above the floor member (9), and an indoor unit (23) disposed on the floor member (9) to supply sucked air as conditioned air. A lower surface (11B) side of the footrest section (11) of the floor member (9) is formed as a unit mounting surface (12), and, as for the indoor unit (23), a box body (24) is disposed on the lower side of the unit mounting surface (12) and, in this state, the box body (24) is mounted on the unit mounting surface (12) by means of a plurality of bolts (32).