Patents by Inventor Toni Kutchan

Toni Kutchan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Morphinan N-demethylase isolated from the methylobacterium thebainfresser and methods of use thereof
    Patent number: 11542481
    Abstract: Disclosed herein are methods for N-demethylating an N-methylated compound using an enzymatic reaction, rather than, e.g. a chemical modification. Also provided herein are enzymes for performing the reaction.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: January 3, 2023
    Assignee: DONALD DANFORTH PLANT SCIENCE CENTER
    Inventors: Toni Kutchan, Megan Augustin
  • MORPHINAN N-DEMETHYLASE ISOLATED FROM THE METHYLOBACTERIUM THEBAINFRESSER AND METHODS OF USE THEREOF
    Publication number: 20190352618
    Abstract: Disclosed herein are methods for N-demethylating an N-methylated compound using an enzymatic reaction, rather than, e.g. a chemical modification. Also provided herein are enzymes for performing the reaction.
    Type: Application
    Filed: January 18, 2018
    Publication date: November 21, 2019
    Inventors: Toni KUTCHAN, Megan AUGUSTIN
  • Methods for high yield production of terpenes
    Patent number: 9534227
    Abstract: Provided are enhanced high yield production systems for producing terpenes in plants via the expression of fusion proteins comprising various combinations of geranyl diphosphate synthase large and small subunits and limonene synthases. Also provided are engineered oilseed plants that accumulate monoterpene and sesquiterpene hydrocarbons in their seeds, as well as methods for producing such plants, providing a system for rapidly engineering oilseed crop production platforms for terpene-based biofuels.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: January 3, 2017
    Assignee: Donald Danforth Plant Science Center
    Inventors: Toni Kutchan, Yasuhiro Higashi, Xiaohong Feng
  • Methods For High Yield Production of Terpenes
    Publication number: 20140081058
    Abstract: Provided are enhanced high yield production systems for producing terpenes in plants via the expression of fusion proteins comprising various combinations of geranyl diphosphate synthase large and small subunits and limonene synthases. Also provided are engineered oilseed plants that accumulate monoterpene and sesquiterpene hydrocarbons in their seeds, as well as methods for producing such plants, providing a system for rapidly engineering oilseed crop production platforms for terpene-based biofuels.
    Type: Application
    Filed: May 13, 2013
    Publication date: March 20, 2014
    Applicant: Donald Danforth Plant Science Center
    Inventors: Toni Kutchan, Yasuhiro Higashi, Xiaohong Feng
  • Cytochrome P450 reductases from poppy plants
    Publication number: 20060185032
    Abstract: The present invention relates to production of alkaloids from poppy plants and in particular togenes encoding enzymes in the alkaloid pathway, to proteins encoded by the gens, to plants transformed or transfected with the genes and to methods of altering alkaloid content or blend of poppy plants.
    Type: Application
    Filed: March 31, 2006
    Publication date: August 17, 2006
    Inventors: Toni Kutchan, Meinhart Zenk, David Atkins, Anthony Fist
  • O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in Papaver somniferum
    Publication number: 20050106588
    Abstract: The present invention relates to methyl transfer enzymes involved in alkaloid biosynthesis in opium poppy. More particularly, the invention relates to proteins having (R,S)-reticuline 7-O-methyltransferase activity, to proteins having (R,S)-norcoclaurine 6-O-methyltransferase activity and to derivatives and analogues of these proteins. The invention also relates to nucleic acid molecules encoding the proteins, and their derivatives and analogues, and to their use in the production of methylated catechols and tetrahydrobenzylisoquinolines.
    Type: Application
    Filed: July 8, 2004
    Publication date: May 19, 2005
    Inventors: Toni Kutchan, Anan Ounaroon, Stefanie Haase, Susanne Frick