Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to cyclopropylamide compounds that are useful in the treatment of parasitic infestations of fish. The compounds have the formula (I).

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention provides a system and method of monitoring brain injury rehabilitation and a rehabilitation method which utilizes a non-invasive monitoring device.

Abstract: Methods, systems and computer program products for implementing high-availability file services in a clustered computing environment. Two or more clusters are interconnected to carry out operations for replication of file content between file servers. The file servers and their respective network links are registered with a file server witness. The file servers operate in synchrony, where each file I/O is replicated from one file server to another file server over a first set of network paths. A file server witness communicates with each file server using a second set of two or more network paths interfaced with respective file servers. The file server witness monitors the file servers to determine operational health of the file servers. Upon receipt of a file I/O request, the file I/O request is directed to one of the two file servers based at least in part on the determined operational health.

Abstract: A process for reducing the benzene content of a light reformate refinery stream comprises the following steps: a) reducing the benzene content by exposing the light reformate to hydrogenation conditions in a benzene-saturation reactor bed, b) increasing the octane number of the hydrogenated light reformate produced in step a) by exposing it to isomerization conditions, c) further reducing the benzene content by exposing the light reformate refinery stream to further hydrogenation conditions, wherein the isomerization of step b) occurs after step a), the hydrogenation of step c) does not precede the isomerization step b), and steps a), b) and c) are all carried out within the same reactor.

Abstract: Systems and computer program products for highly available computing systems. Techniques for verifying a replicated snapshot integrity includes steps for storing a snapshot at a first computing system where the snapshot has a corresponding first data integrity value (e.g., a checksum). Another storing operation stores a replica snapshot as two or more portions at respective two or more computing nodes of a second computing system. A second data integrity value that corresponds to the snapshot that was stored at the two or more computing nodes is calculated. Corruption is detected by comparing the first data integrity value to the second data integrity value. Corruption of a to-be-assembled snapshot can be detected before incurring the cost of assembly of the two or more portions of a replica snapshot. Alternative snapshots that can be assembled from alternative portions are considered for assembly. Only uncorrupted snapshots are restored to a designated computing system.

Abstract: A process for reducing the benzene content of a light reformate refinery stream comprises the following steps: a) reducing the benzene content by exposing the light reformate to hydrogenation conditions in a benzene-saturation reactor bed, b) increasing the octane number of the hydrogenated light reformate produced in step a) by exposing it to isomerization conditions, c) further reducing the benzene content by exposing the light reformate refinery stream to further hydrogenation conditions, wherein the isomerization of step b) occurs after step a), the hydrogenation of step c) does not precede the isomerization step b), and steps a), b) and c) are all carried out within the same reactor.

Abstract: A device for simultaneously measuring and adjusting the tool holding portion of a spindle. The device has a body defining a datum surface providing a magnetic portion and an indicator portion. A socket extends from the magnetic portion, the socket dimensioned and adapted to receive and seat a first component of the tool holding portion on the magnetic portion. A compressible indicator tip extends in an outward-biased manner from the indicator portion, wherein a distance from the distal end of the indicator tip and the indicator portion of the datum surface is displayed along the body.

Abstract: A method and apparatus for monitoring brain activity of a user is disclosed. The apparatus includes a plurality of spatially separated emitters operable to generate infrared radiation. The apparatus also includes a plurality of spatially separated infrared radiation detectors, and a plurality of light pipes urged into contact with the user's scalp, each one of the plurality of emitters and detectors having an associated light pipe operable to couple infrared radiation from the emitter into the scalp or to couple infrared radiation from the scalp to the detector.

Abstract: A device for simultaneously measuring and adjusting the tool holding portion of a spindle. The device has a body defining a datum surface providing a magnetic portion and an indicator portion. A socket extends from the magnetic portion, the socket dimensioned and adapted to receive and seat a first component of the tool holding portion on the magnetic portion. A compressible indicator tip extends in an outward-biased manner from the indicator portion, wherein a distance from the distal end of the indicator tip and the indicator portion of the datum surface is displayed along the body.

Abstract: Systems and computer program products for highly available computing systems. Techniques for verifying a replicated snapshot integrity includes steps for storing a snapshot at a first computing system where the snapshot has a corresponding first data integrity value (e.g., a checksum). Another storing operation stores a replica snapshot as two or more portions at respective two or more computing nodes of a second computing system. A second data integrity value that corresponds to the snapshot that was stored at the two or more computing nodes is calculated. Corruption is detected by comparing the first data integrity value to the second data integrity value. Corruption of a to-be-assembled snapshot can be detected before incurring the cost of assembly of the two or more portions of a replica snapshot. Alternative snapshots that can be assembled from alternative portions are considered for assembly. Only uncorrupted snapshots are restored to a designated computing system.

Abstract: Clustered computing system monitoring, fault prediction and remediation. The disclosed techniques are used for predicting an impending occurrence of a fault. Prediction techniques involve gathering historical data pertaining to storage I/O operations performed in a clustered computing system. Ongoing storage I/O operations that are performed when a first node accesses data in local storage device as well as ongoing storage I/O operations that are performed when the first node accesses data in a remote storage device of a second node are monitored over time. On an ongoing basis, the monitored storage I/O operations are analyzed to identify impending remediable events. Before recurrence of a predicted impending remediable event, conditions that are known to have been present at the time of a historical fault are ameliorated. In some embodiments, avoidance of an impending remediable event is accomplished by moving data stored at a remote storage device to a local storage device.

Abstract: Methods, systems and computer program products for implementing high-availability file services in a clustered computing environment. Two or more clusters are interconnected to carry out operations for replication of file content between file servers. The file servers and their respective network links are registered with a file server witness. The file servers operate in synchrony, where each file I/O is replicated from one file server to another file server over a first set of network paths. A file server witness communicates with each file server using a second set of two or more network paths interfaced with respective file servers. The file server witness monitors the file servers to determine operational health of the file servers. Upon receipt of a file I/O request, the file I/O request is directed to one of the two file servers based at least in part on the determined operational health.

Abstract: A bite rim system includes a plurality of dental bite rims having a shape and size that is suitable for use in a human mouth. A plurality of anatomically correct replica teeth are provided that include various tooth characteristics of different shapes, thicknesses, sizes and colors. A series of replica teeth are removably pre-mounted onto one or more of the bite rims in an anatomically correct pattern. The system also includes one or more replica teeth strips having a front facing surface with the image of one or more teeth imprinted thereon, and a back facing surface that is coated with an adhesive material for mating with one of the dental bite rims.

Abstract: Activity monitors and smart watches utilizing optical measurements are becoming widely popular, and users expect to get an increasingly accurate estimate of their heart rate (HR) from these devices. These devices are equipped with a light source and an optical sensor which enable estimation of HR using a technique called photoplethysmography (PPG). One of the main challenges of HR estimation using PPG is the coupling of motion into the optical PPG signal when the user is moving randomly or exercising. The present disclosure describes a computationally feasible and fast HR estimation algorithm to be executed at instances of little or no motion. Resulting HR readings may be useful on their own, or be provided to systems that monitor HR continuously to prevent the problem of such systems being locked on an incorrect HR for long periods of time. Implementing techniques described herein leads to more accurate HR measurements.

Abstract: A bite rim system includes a plurality of dental bite rims having a shape and size that is suitable for use in a human mouth. A plurality of anatomically correct replica teeth is constructed from wax, and also includes various tooth characteristics of different shapes, thicknesses, sizes and colors. A series of replica teeth are removably pre-mounted onto one or more of the bite rims in an anatomically correct pattern. The system also includes one or more replica teeth strips having a front facing surface with the image of one or more teeth imprinted thereon, and a back facing surface that is coated with an adhesive material for mating with one of the dental bite rims.

Abstract: Activity monitors and smart watches utilizing optical measurements are becoming widely popular, and users expect to get an increasingly accurate estimate of their heart rate (HR) from these devices. These devices are equipped with a light source and an optical sensor which enable estimation of HR using a technique called photoplethysmography (PPG). One of the main challenges of HR estimation using PPG is the coupling of motion into the optical PPG signal when the user is moving randomly or exercising. The present disclosure describes a computationally feasible and fast HR estimation algorithm to be executed at instances of little or no motion. Resulting HR readings may be useful on their own, or be provided to systems that monitor HR continuously to prevent the problem of such systems being locked on an incorrect HR for long periods of time. Implementing techniques described herein leads to more accurate HR measurements.

Abstract: A bite rim system includes a plurality of dental bite rims having a shape and size that is suitable for use in a human mouth. A plurality of anatomically correct replica teeth is constructed from wax, and also includes various tooth characteristics of different shapes, thicknesses, sizes and colors. A series of replica teeth are removably pre-mounted onto one or more of the bite rims in an anatomically correct pattern. The system also includes one or more replica teeth strips having a front facing surface with the image of one or more teeth imprinted thereon, and a back facing surface that is coated with an adhesive material for mating with one of the dental bite rims.