Patents by Inventor Tony Peled

Tony Peled has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of improving stem cell homing and engraftment
    Patent number: 8846393
    Abstract: A method of enhancing cell engraftment potential is provided. The method comprising ex-vivo or in-vitro subjecting a population of cells to an amount of nicotinamide for a period of time sufficient to effect the population of cells, thereby enhancing cell engraftment potential.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: September 30, 2014
    Assignee: Gamida-Cell Ltd.
    Inventor: Tony Peled
  • Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby
    Publication number: 20140023623
    Abstract: A method of culturing mesenchymal stem cells (MSCs) is provided. The method comprising culturing a population of the MSCs in a medium comprising an aryl hydrocarbon receptor antagonist, thereby culturing MSCs.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 23, 2014
    Inventors: Tony Peled, Yair Steinhardt
  • Enhancement of Natural Killer (NK) Cell Proliferation and Activity
    Publication number: 20140023626
    Abstract: Methods of ex-vivo culture of natural killer (NK) cells are provided and, more particularly, methods for enhancing propagation and/or functionality of NK cells by treating the cells with an aryl hydrocarbon antagonist in combination with cytokines driving NK cell proliferation. Also envisioned are compositions comprising cultured NK cells and therapeutic uses thereof.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 23, 2014
    Inventors: Tony Peled, Gabi M. Frei
  • Expansion Of Stem/Progenitor Cells By Inhibition Of Enzymatic Reactions Catalyzed By The Sir2 Family Of Enzymes
    Publication number: 20130209414
    Abstract: Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.
    Type: Application
    Filed: April 17, 2012
    Publication date: August 15, 2013
    Applicant: Gamida Cell Ltd.
    Inventor: Tony Peled
  • Methods for Enhancing Natural Killer Cell Proliferation and Activity
    Publication number: 20130011376
    Abstract: Methods of ex-vivo culture of natural killer (NK) cells are provided and, more particularly, methods for enhancing propagation and/or functionality of NK cells by treating the cells with a nicotinamide or other nicotinamide moiety in combination with cytokines driving NK cell proliferation. Also envisioned are compositions comprising cultured NK cells and therapeutic uses thereof.
    Type: Application
    Filed: December 29, 2010
    Publication date: January 10, 2013
    Applicant: GAMIDA CELL LTD.
    Inventors: Tony Peled, Gabi M. Frei
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 8202724
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: June 19, 2012
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods for Selecting Expanded Stem Cell Populations
    Publication number: 20120141434
    Abstract: A method and criteria are provided for selecting expanded hematopoietic stem cell populations for allogenic transplantation, the selected cell populations having high probability of engraftment and positive clinical outcome.
    Type: Application
    Filed: May 5, 2010
    Publication date: June 7, 2012
    Applicant: Gamida Cell Ltd.
    Inventors: Tony Peled, Dorit Harati
  • Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes
    Patent number: 8187876
    Abstract: Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: May 29, 2012
    Assignee: Gamida Cell Ltd.
    Inventor: Tony Peled
  • Methods of ex vivo hematopoietic stem cell expansion by co-culture with mesenchymal cells
    Patent number: 8080417
    Abstract: Methods of ex-vivo expansion and at the same time inhibiting differentiation of stem cells by co-culture with mesenchymal cells, transplantable populations of renewable progenitor and stem cells expanded thereby, and their uses in therapeutic applications.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: December 20, 2011
    Assignee: Gamida-Cell Ltd.
    Inventors: Tony Peled, Arik Hasson
  • Expansion of renewable stem cell populations
    Patent number: 7955852
    Abstract: Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: June 7, 2011
    Assignee: Gamida Cell Ltd.
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells
    Publication number: 20110045589
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: October 6, 2010
    Publication date: February 24, 2011
    Applicants: Gamida Cell LTD., Hadasit Medical Research Services And Development LTD.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Expansion Of Renewable Stem Cell Populations
    Publication number: 20110033427
    Abstract: Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
    Type: Application
    Filed: October 20, 2010
    Publication date: February 10, 2011
    Applicant: Gamida Cell LTD.
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7855075
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: December 21, 2010
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of Improving Stem Cell Homing and Engraftment
    Publication number: 20100061963
    Abstract: A method of enhancing cell engraftment potential is provided. The method comprising ex-vivo or in-vitro subjecting a population of cells to an amount of nicotinamide for a period of time sufficient to effect the population of cells, thereby enhancing cell engraftment potential.
    Type: Application
    Filed: November 29, 2006
    Publication date: March 11, 2010
    Inventor: Tony Peled
  • Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
    Patent number: 7655225
    Abstract: Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and/or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and/or progenitor cells.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: February 2, 2010
    Assignee: Gamida Cell, Ltd.
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20090004158
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: May 19, 2008
    Publication date: January 1, 2009
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Expansion of Stem/Progenitor Cells by Inhibition of Enzymatic Reactions Catalyzed by the Sir2 Family of Enzymes
    Publication number: 20090004191
    Abstract: Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.
    Type: Application
    Filed: July 14, 2005
    Publication date: January 1, 2009
    Inventor: Tony Peled
  • Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
    Publication number: 20080279828
    Abstract: Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and/or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and/or progenitor cells.
    Type: Application
    Filed: February 19, 2008
    Publication date: November 13, 2008
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7429489
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: September 30, 2008
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Use of ex-vivo cultured hematopoietic cells for treatment of peripheral vascular diseases
    Publication number: 20080199441
    Abstract: Methods for cell therapy of peripheral vascular disease by local administration of ex-vivo cultured hematopoietic cells are provided.
    Type: Application
    Filed: November 8, 2007
    Publication date: August 21, 2008
    Inventor: Tony Peled