Patents by Inventor Tony Romeo

Tony Romeo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel genes involved in the escherichia coli biofilm formation and uses thereof
    Publication number: 20050032093
    Abstract: The present invention relates to biofilm genes, their polypeptides, and the use of such genes, polypeptides and control regions in determining compositions for use in the disruption of biofilms and the treatment of disease. The identified compositions regulate the expression of the biofilm genes or modulate the activity of their protein products.
    Type: Application
    Filed: April 16, 2004
    Publication date: February 10, 2005
    Inventors: Tony Romeo, Xin Wang, Rebecca Desplas
  • Compounds and methods for modulating bacterial functions
    Publication number: 20040171517
    Abstract: There is provided a method of reducing biofilm formation by biofilm-forming bacterial strains such as E. coli, Salmonella, Klebsiella, or a related gamma proteobacteria. CsrA activity levels in the cell may be modulated to impact biofilm formation and glycogen metabolism. CsrA levels may be modulated by modulating the expression of csrB RNA and UvrY and BarA gene products. By increasing levels of CsrB, BarA or SdiA in a bacterial cell or increasing the rate of UvrY phosphorylation, one can increase the levels of active UvrY in the strain. There is also provided a modulator of CsrA activity in a bacteria comprising a nucleotide sequence containing the sequence element CAGGAUG.
    Type: Application
    Filed: September 29, 2003
    Publication date: September 2, 2004
    Inventors: Tony Romeo, Xin Wang, Kazushi Suzuki
  • Methods for polysaccharide adhesion synthesis modulation
    Publication number: 20040116371
    Abstract: There is provided a method for modulation of polysaccharide adhesin synthesis involving products of the ycdSRQP gene operon in bacteria, depicted in SEQ. ID. NO. 1 and 2. Also provided is the use of an inhibitor of a product of the ycdSRQP operon in improving the response of a mammalian patient suffering from a bacterial infection.
    Type: Application
    Filed: September 29, 2003
    Publication date: June 17, 2004
    Inventors: Tony Romeo, Xin Wang
  • Methods and compounds for reducing biofilm formulation
    Publication number: 20040009927
    Abstract: The invention relates to methods and compositions for modulating the biofilm formation by bacteria. In particular, the invention provides a method for reducing biofilm formation by bacteria comprising administering a control agent wherein the control agent is glucose, a glucose analogue, an adenylate cyclase inhibitor, a phosphodiesterase inhibitor, or a IIAGlc dephosphorylation stimulator. The invention also provides a method for enhancing biofilm formation by bacteria comprising administering cAMP or a cAMP analogue.
    Type: Application
    Filed: May 13, 2003
    Publication date: January 15, 2004
    Inventors: Tony Romeo, Debra W. Jackson, Jerry W. Simecka
  • Escherichia coli csrB gene, RNA encoded thereby, and methods of use thereof
    Publication number: 20030190752
    Abstract: The invention includes the gene csrB, the RNA encoded thereby and methods of use thereof. csrB RNA binds to and antagonizes the ability of CsrA to down-regulate the production of certain metabolic products. This invention is also drawn to methods of using csrB polynucleotides, and combination of csrB polynucleotides and CsrA polypeptides and antibodies that bind to such combinations.
    Type: Application
    Filed: March 24, 2003
    Publication date: October 9, 2003
    Inventor: Tony Romeo
  • Method of altering the expression of csrB to modify the properties of a cell
    Patent number: 6537815
    Abstract: The invention includes the gene csrB, the RNA encoded thereby and methods of use thereof. csrB RNA binds to and antagonizes the ability of CsrA to down-regulate the production of certain metabolic products. This invention is also drawn to methods of using csrB polynucleotides, and combination of csrB polynucleotides and CsrA polypeptides and antibodies that bind to such combinations.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: March 25, 2003
    Assignee: University of North Texas, Health Science Center at Fort Worth
    Inventor: Tony Romeo
  • Escherichia coli csrB gene, RNA encoded thereby, and methods of use thereof
    Publication number: 20020015983
    Abstract: The invention includes the gene csrB, the RNA encoded thereby and methods of use thereof. csrB RNA binds to and antagonizes the ability of CsrA to down-regulate the production of certain metabolic products. This invention is also drawn to methods of using csrB polynucleotides, and combination of csrB polynucleotides and CsrA polypeptides and antibodies that bind to such combinations.
    Type: Application
    Filed: December 13, 2000
    Publication date: February 7, 2002
    Inventor: Tony Romeo
  • Escherichia coli csrA gene, protein encoded thereby, and methods of use thereof
    Patent number: 6268471
    Abstract: The invention includes a gene encoding csrA, the protein encoded thereby and methods of use thereof.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 31, 2001
    Assignee: University of North Texas Health Science Center at Forth Worth
    Inventor: Tony Romeo
  • Escherichia coli CSRB gene and RNA encoded thereby
    Patent number: 6228638
    Abstract: The invention includes the gene csrB, the RNA encoded thereby and methods of use thereof. csrB RNA binds to and antagonizes the ability of CsrA to down-regulate the production of certain metabolic products. This invention is also drawn to methods of using csrB polynucleotides, and combination of csrB polynucleotides and CsrA polypeptides and antibodies that bind to such combinations.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: May 8, 2001
    Assignee: University of North Texas, Health Science Center at Fort Worth
    Inventor: Tony Romeo
  • Escherichia coli csrA gene, protein encoded thereby, and methods of use thereof
    Patent number: 5684144
    Abstract: The invention includes a gene encoding csrA, the protein encoded thereby and methods of use thereof.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: November 4, 1997
    Assignee: University of North Texas
    Inventor: Tony Romeo