Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: A circuit arrangement includes an array of switches that represent a Boolean satisfiability expression that has a plurality of clauses each defined by a combination of Boolean variables Xi or ¬Xi, a first plane, and a constraints network operatively arranged with the first plane. The constraints network enforces each of the clauses such that values of different ones of the variables continue to randomly or pseudo randomly flip until the values of the variables Xi and ¬Xi stop changing or a predetermined condition occurs.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses a molecule having the following formula.

Abstract: To present augmented reality features without localizing a user, a client device receives a request for presenting augmented reality features in a camera view of a computing device of the user. Prior to localizing the user, the client device obtains sensor data indicative of a pose of the user, and determines the pose of the user based on the sensor data with a confidence level that exceeds a confidence threshold which indicates a low accuracy state. Then the client device presents one or more augmented reality features in the camera view in accordance with the determined pose of the user while in the low accuracy state.

Abstract: A connector comprises an insulation housing, a shielding shell, an inner sheath, and an outer sheath. The shielding shell is sheathed on the insulation housing. The inner sheath is formed on the shielding shell by injection molding. The inner sheath includes a front end wrapped on the shielding shell and a retaining portion formed on the front end of the inner sheath and spaced from the shielding shell to form a gap therebetween. The outer sheath is formed on the shielding shell and the inner sheath by injection molding. The outer sheath includes an engaging portion embedded in the gap between the retaining portion and the shielding shell. The retaining portion holds the engaging portion on the shielding shell to prevent the formation of a gap between the front end of the outer sheath and the shielding shell.

Abstract: A client device is configured to (i) based on initial sensor data and a road network graph maintained on the client device, determine a set of particles corresponding to the road network graph, each particle including a (a) trajectory along the road network graph, (b) position and velocity, and (c) probability, (ii) identify a particle with a highest probability, (iii) based on the identified particle, determine the location of the client device in the road network graph, (iv) after receiving new sensor data, extend the trajectory of each particle, (v) based on the new sensor data, update, for each particle (a) the position and velocity and (b) the probability, (vi) identify a particle from the second updated set of particles with a highest probability, and (vii) based on the identified particle, determine the updated location of the client device in the road network graph.

Abstract: A motor controller for a pump motor is provided. The motor controller includes an input device and a memory configured to store a plurality of actuation sequences and a plurality of commands. Each actuation sequence is associated with a command. The motor controller further includes a processor coupled to the input device, the memory, and the pump motor. The processor is configured to detect at the input device, a first actuation sequence in response to the input device being actuated. The processor is further configured to perform a lookup in the memory to determine a first command corresponding to the first actuation sequence. The processor is further configured to operate the pump motor according to the first command.

Abstract: An ice level sensor in an appliance that includes an ice storage housing and an ice maker. The housing receives ice from the ice maker. The ice level sensor includes a control circuit and one or more electrode arrays capable of detecting ice in the housing. The electrode arrays each contain one or more sense electrodes, and the control circuit detects ice in the housing based on a measurement of capacitance of the sense electrode(s). When the sensor detects that ice in the housing has reached a threshold level, the sensor can stop the ice maker from depositing more ice into the housing, to prevent overflow. The ice level sensor detects that ice has reached a threshold level by detecting changes in capacitance of a sense electrode or by detecting that the capacitance of a sense electrode reached a predetermined value.

Abstract: A method and system for calculating a cold junction temperature comprises an offline phase comprising: determining an applicable algorithm for calculating a cold junction screw temperature, and deploying the applicable algorithm in firmware; and an online phase comprising: providing at least one measured temperature to the applicable algorithm deployed in firmware, calculating a temperature of a cold junction screw according to the applicable algorithm deployed in firmware, and assigning the calculated temperature of the cold junction screw as a cold junction temperature.