Patents by Inventor Tor Kihlberg

Tor Kihlberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Miniaturized liquid surface reactions using nanomolar amounts of concentrated [C]carbon dioxide in a stationary gas-phase
    Patent number: 8679452
    Abstract: Methods and reagents for miniaturized carboxylation with carbon-isotope labeled carbon dioxide using Grignard reagents or other organometallic reagents in a closable reaction loop or reactor are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals or precursors for radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: March 25, 2014
    Assignee: GE Healthcare Limited
    Inventors: Tor Kihlberg, Bengt Langstrom
  • Method and apparatus for the use of [C] carbon monoxide in labeling synthesis by photo-initiated carbonylation
    Patent number: 8282888
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: October 9, 2012
    Assignee: GE Healthcare Limited
    Inventors: Tor Kihlberg, Oleksiy Itsenko, Tommy Ferm, Bengt Langstrom
  • Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled ketones by photo-induced free radical carbonylation
    Patent number: 8273861
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with carbanion precursors pretreated by a base are provided. The resultant carbon-isotope labeled ketones, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: September 25, 2012
    Assignee: GE Healthcare Limited
    Inventors: Bengt Langstrom, Oleksiy Itsenko, Tor Kihlberg
  • Method and apparatus for synthesis of [C]phosgene using concentrated [C] carbon monoxide with UV light
    Patent number: 8137656
    Abstract: Methods and systems for labeling synthesis of phosgen by UV light are provided. Methods of synthesizing labeled compounds useful as PET tracers from labeled phosgen are also provided. The resultant carbon-isotope labeled compounds are useful as radio-pharmaceuticals, especially for use in Positron Emission Tomography. Associated kits for PET studies are also provided.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: March 20, 2012
    Assignee: GE Healthcare Limited
    Inventors: Tor Kihlberg, Tommy Ferm, Bengt Langstrom
  • Method for the use of [C] carbon monoxide in labeling synthesis of C-labelled amides using metal amides and photo-induced free radical carbonylation
    Patent number: 8129528
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: March 6, 2012
    Assignee: GE Healthcare Limited
    Inventors: Oleksiy Itsenko, Tor Kihlberg, Bengt Langstrom
  • Methods for carbon isotope labeling synthesis of ketones and amines by Suzuki coupling reactions using carbon-isotope monoxide
    Patent number: 8076464
    Abstract: Methods and reagents for synthesizing carbon-isotope labeled ketones and amines by carbonylation via Suzuki coupling reaction using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled ketones and amines are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: December 13, 2011
    Assignee: GE Healthcare Limited
    Inventors: Obaidur Rahman, Bengt Langstrom, Tor Kihlberg, Jordi Llop
  • SYNTHESIS OF [18F]-LABELLED ALKYL MESYLATES USING FLUOROUS SPE SEPARATION
    Publication number: 20110251432
    Abstract: The invention relates to new processes for preparation of 18F-labelled alkylation reagents that can be used in the alkylation of amines that are suitable for use in labelling of Positron Emission Tomography (PET) radiotracers.
    Type: Application
    Filed: August 27, 2008
    Publication date: October 13, 2011
    Inventors: Bengt Langstrom, Tor Kihlberg
  • METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED ESTERS BY PHOTO-INDUCED FREE RADICAL CARBONYLATION
    Publication number: 20100061931
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Application
    Filed: November 19, 2009
    Publication date: March 11, 2010
    Inventors: Bengt Langstrom, Oleksiy Itsenko, Tor Kihlberg
  • METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED AMIDES USING METAL AMIDES AND PHOT-INDUCED FREE RADICAL CARBONYLATION
    Publication number: 20090297445
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Application
    Filed: June 4, 2009
    Publication date: December 3, 2009
    Inventors: Oleksiy Itsenko, Tor Kihlberg, Bengt Langstrom
  • Method for the use of [C] carbon monoxide in labeling synthesis of C-labelled esters by photo-induced free radical carbonylation
    Patent number: 7626052
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: December 1, 2009
    Assignee: GE Healthcare Limited
    Inventors: Bengt Langstrom, Oleksiy Itsenko, Tor Kihlberg
  • METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED KETONES BY PHOTO-INDUCED FREE RADICAL CARBONYLATION
    Publication number: 20090208414
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with carbanion precursors pretreated by a base are provided. The resultant carbon-isotope labeled ketones, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided.
    Type: Application
    Filed: August 29, 2006
    Publication date: August 20, 2009
    Inventors: Bengt Langstrom, Oleksiy Itsenko, Tor Kihlberg
  • Method and apparatus for the use of [11C] Carbon Monoxide in Labeling Synthesis by Photo-Initiated Carbonylation
    Publication number: 20090203909
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Application
    Filed: April 14, 2009
    Publication date: August 13, 2009
    Inventors: Tor Kihlberg, Oleksiy Itsenko, Tommy Ferm, Bengt Langstrom
  • Method for the use of [C] carbon monoxide in labeling synthesis of C-labelled amides using metal amides and photo-induced free radical carbonylation
    Patent number: 7553942
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: June 30, 2009
    Assignee: GE Healthcare Limited
    Inventors: Oleksiy Itsenko, Tor Kihlberg, Bengt Langstrom
  • Method and apparatus for the use of [C] carbon monoxide in labeling synthesis by photo-initiated carbonylation
    Patent number: 7521544
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: April 21, 2009
    Assignee: GE Healthcare Limited
    Inventors: Tor Kihlberg, Oleksiy Itsenko, Tommy Ferm, Bengt Langstrom
  • MINIATURIZED LIQUID SURFACE REACTIONS USING NANOMOLAR AMOUNTS OF CONCENTRATED [11C]CARBON DIOXIDE IN A STATIONARY GAS-PHASE
    Publication number: 20090092549
    Abstract: Methods and reagents for miniaturized carboxylation with carbon-isotope labeled carbon dioxide using Grignard reagents or other organometallic reagents in a closable reaction loop or reactor are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals or precursors for radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Application
    Filed: December 19, 2006
    Publication date: April 9, 2009
    Inventors: Tor Kihlberg, Bengt Langstrom
  • Non Thermal Plasma Method to Prepare [11C] Methyl Iodide From [11C] Methane and Iodine Methane and Iodine
    Publication number: 20080306313
    Abstract: A method and an apparatus for preparing [11C]methyl iodide from [11C]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [11C]methane used in the experiments was produced from [11C]carbon dioxide via reduction with hydrogen over nickel. [11C]Methyl iodide was obtained with a specific radioactivity of 412±32 GBq/?mol within 6 min from approximately 24 GBq of [11C]carbon dioxide. The decay corrected radiochemical yield was 13±3% based on [11C]carbon dioxide at start of synthesis. [11C]Flumazenil was synthesized via a N-alkylation with the prepared [11C]methyl iodide. Kit and apparatus for preparing [11C]methyl iodide by a non thermal plasma method are also provided.
    Type: Application
    Filed: December 12, 2006
    Publication date: December 11, 2008
    Inventors: Jonas Eriksson, Tor Kihlberg, Bengt Langstrom, Johan Ulin
  • Methods and Apparatus for Production and Use of [11C] Carbon Monoxide in Labeling Synthesis
    Publication number: 20080095693
    Abstract: Methods and apparatus for production and use of carbon-isotope monoxide in labeling synthesis are provided. The resultant carbon-isotope labeled reagents are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET).
    Type: Application
    Filed: July 8, 2005
    Publication date: April 24, 2008
    Inventors: Tor Kihlberg, Bengt Langstrom, Tommy Ferm, Jonas Erikson
  • Methods for Carbon Isotope Labeling Synthesis of Ketones and Amines by Suzuki Coupling Reactions Using Carbon-Isotope Monoxide
    Publication number: 20070280883
    Abstract: Methods and reagents for synthesizing carbon-isotope labeled ketones and amines by carbonylation via Suzuki coupling reaction using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled ketones and amines are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Application
    Filed: December 20, 2004
    Publication date: December 6, 2007
    Inventors: Obaidur Rahman, Bengt Langstrom, Tor Kihlberg, Jordi Llop
  • Method and apparatus for synthesis of [11c] phosgen using concentrated [11c] carbon monoxide with uv light
    Publication number: 20070110664
    Abstract: Methods and systems for labeling synthesis of phosgen by UV light are provided. Methods of synthesizing labeled compounds useful as PET tracers from labeled phosgen are also provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography. Associated kits for PET studies are also provided.
    Type: Application
    Filed: November 29, 2004
    Publication date: May 17, 2007
    Inventors: Tor Kihlberg, Tommy Ferm, Bengt Langstrom
  • Method and apparatus for the use of [11c] carbon monoxide in labeling synthesis by photo-intiated carbonylation
    Publication number: 20070043213
    Abstract: Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
    Type: Application
    Filed: October 25, 2004
    Publication date: February 22, 2007
    Inventors: Tor Kihlberg, Oleksiy Itsenko, Tommy Ferm, Bengt Langstrom