Patents by Inventor Torgrim Engell

Torgrim Engell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for removing acetaldehyde
    Patent number: 11964020
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Grant
    Filed: June 13, 2022
    Date of Patent: April 23, 2024
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • CASSETTE FOR STABILISED RADIOLABELLING REACTION
    Publication number: 20230120841
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).
    Type: Application
    Filed: December 21, 2022
    Publication date: April 20, 2023
    Inventors: Torgrim Engell, Alexander JACKSON, Imtiaz Ahmed KAHN, Alan Peter CLARKE, Graeme MCROBBIE, Julian Grigg
  • Stabilized radiolabelling reaction
    Patent number: 11565257
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: January 31, 2023
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Alexander Jackson, Imtiaz Ahmed Khan, Alan Peter Clarke, Graeme McRobbie, Julian Grigg
  • METHOD FOR REMOVING ACETALDEHYDE
    Publication number: 20220305126
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Application
    Filed: June 13, 2022
    Publication date: September 29, 2022
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • Method for removing acetaldehyde
    Patent number: 11389538
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: July 19, 2022
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • RADIOTRACER COMPOSITIONS AND METHODS
    Publication number: 20220202965
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Application
    Filed: March 15, 2022
    Publication date: June 30, 2022
    Inventors: Torgrim ENGELL, Gareth Simon GETVOLDSEN, Andreas Richard MEIJER, Imtiaz Ahmed KHAN, Graeme MCROBBIE, Robert James NAIRNE
  • Radiotracer compositions and methods
    Patent number: 11311636
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: April 26, 2022
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Graeme McRobbie, Robert James Nairne
  • PURIFICATION METHOD AND COMPOSITIONS
    Publication number: 20210330824
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of purifying a radiotracer which comprises 18F-labelled aminoxy-functionalised biological targeting moiety. The invention provides radioprotectant-containing radiopharmaceutical compositions of the tracers, as well as associated automated methods and cassettes.
    Type: Application
    Filed: May 7, 2021
    Publication date: October 28, 2021
    Inventors: Torgrim Engell, Andreas Meijer, Imtias Ahmed Khan, Robert James Nairne, Graeme McRobbie
  • SOLID PHASE EXTRACTION
    Publication number: 20210023558
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is amenable to automation. In particular, the method of the present invention comprises a method of purification carried out by means of solid phase extraction (SPE) alone.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 28, 2021
    Inventors: Torgrim Engell, Alexander JACKSON, Alexander Imtiaz KAHN, Alan P. CLARKE, Walter Graeme MCROBBIE, Julian Grigg
  • STABILISED RADIOLABELLING REACTION
    Publication number: 20210017098
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Inventors: Torgrim Engell, Alexander JACKSON, Alexander Imtiaz KAHN, Alan P. CLARKE, Walter Graeme MCROBBIE, Julian Grigg
  • Method of operating an automated radiopharmaceutical synthesizer
    Patent number: 10758887
    Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: September 1, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Ingvil Gausemel, Knut Dyrstad, Jonathan R. Shales
  • METHOD FOR REMOVING ACETALDEHYDE
    Publication number: 20200237921
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Application
    Filed: April 15, 2020
    Publication date: July 30, 2020
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • Method for removing acetaldehyde
    Patent number: 10660966
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: May 26, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • RADIOTRACER COMPOSITIONS AND METHODS
    Publication number: 20190275182
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Application
    Filed: April 4, 2019
    Publication date: September 12, 2019
    Inventors: Torgrim ENGELL, Gareth Simon GETVOLDSEN, Andreas Richard MEIJER, Imtiaz Ahmed KHAN, Graeme MCROBBIE, Robert James NAIRNE
  • Radiotracer compositions and methods
    Patent number: 10300156
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: May 28, 2019
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Robert James Nairne, Graeme McRobbie
  • METHOD OF OPERATING AN AUTOMATED RADIOPHARMACEUTICAL SYNTHESIZER
    Publication number: 20190001296
    Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
    Type: Application
    Filed: July 23, 2018
    Publication date: January 3, 2019
    Inventors: Torgrim Engell, Julian Grigg, Ingvil Gausemel, Knut Dyrstad, Jonathan R. Shales
  • Method of operating an automated radiopharmaceutical synthesizer
    Patent number: 10029228
    Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 24, 2018
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Julian Grigg, Ingvil Gausemel, Knut Dyrstad, Jonathan R. Shales
  • Radiotracer compositions
    Patent number: 9987382
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 5, 2018
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
  • METHOD FOR REMOVING ACETALDEHYDE
    Publication number: 20170360943
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Application
    Filed: December 4, 2015
    Publication date: December 21, 2017
    Applicant: GE Healthcare Limited
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • Use of aniline in the radiostabilization of oxime ligation
    Patent number: 9567372
    Abstract: A method of radiostabilizing an oxime ligation or imine formation reaction using aniline is described.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 14, 2017
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Nigel Osborn