Patents by Inventor Torleif Utne

Torleif Utne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for L-dopa
    Patent number: 4716246
    Abstract: A process for the preparation of (S)- or L-3-(3,4-dihydroxyphenyl)alanine (L-dopa) is described. The process utilizes water as reaction process solvent and proceeds via formation of an intermediate which can be kinetically resolved in a polar solvent to a precursor of the desired isomer and in which the undesired isomer can be efficiently racemized for reuse.
    Type: Grant
    Filed: August 22, 1986
    Date of Patent: December 29, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Donald F. Reinhold, Torleif Utne, Newton L. Abramson
  • Displacement purification of salts
    Patent number: 4329469
    Abstract: An optically impure diastereomeric salt is purified by treating a suspension of the salt in an appropriate solvent or solvent mixture with the required amount of the desired, optically pure, acid or base.
    Type: Grant
    Filed: November 24, 1980
    Date of Patent: May 11, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Torleif Utne, Ronald B. Jobson
  • Preparation of 4-aza-17-substituted-5.alpha.-androstan-3-ones useful as 5.alpha.-reductase inhibitors
    Patent number: 4220775
    Abstract: A method of preparing a compound of the formula: ##STR1## where Formula (I) may also have the structure of partial Formula (III); wherein, ##STR2## R' is hydrogen or methyl; R" is hydrogen or .beta.-methyl;R'" is .beta.-methyl or hydroxy;Z is (1) oxo;(2) .beta.-hydrogen and .alpha.-hydroxy; or .alpha.-hydrogen or .alpha.-hydroxyl and(3) (Y).sub.n Q where n=0 or 1, Y is a straight or branched hydrocarbon chain of 1 to 12 carbon atoms andQ is ##STR3## where R.sup.8 is, ##STR4## where the dashed bond replaces the 17.alpha. hydrogen; (6) cyano; or(7) tetrazolyl;and pharmaceutically acceptable salts of the above compounds;CHARACTERIZED IN THAT(I.) a compound of the formula: ##STR5## , where A has the meanings above except --CH.dbd.CH--, is (1) treated with an oxidizing agent at reduced temperatures to form the corresponding 5-oxo-3,5-seco-androstan-3-oic acid compound;(2) treating the product of step (1) with an amine of formula: R.sup.1 NH.sub.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Gary H. Rasmusson, David B. R. Johnston, Donald F. Reinhold, Torleif Utne, Ronald B. Jobson
  • Preparation of biphenyl compounds
    Patent number: 3992459
    Abstract: Biaryl coupling, particularly to form 2,4-difluorobiphenyl, is accomplished by diazotizing an aniline and coupling the benzenediazonium salt with a second aromatic component in the presence of a strong acid, an inert finely divided solid and copper powder or a copper salt.
    Type: Grant
    Filed: May 1, 1975
    Date of Patent: November 16, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Torleif Utne, Ronald B. Jobson, Alfred V. Lovell