Abstract: The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine A2 receptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine A2 receptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine A2 receptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Abstract: A vibration structure that includes a piezoelectric film constructed to deform in a plane direction as a voltage is applied thereto, a frame-shaped member, a vibration portion surrounded by the frame-shaped member in a plan view of the vibration structure, a support portion connecting the vibration portion and the frame-shaped member, and supporting the vibration portion within the frame-shaped member such that the vibration portion vibrates in the plane direction when the piezoelectric film is deformed in the plane direction, a first connection member that connects the piezoelectric film to the vibration portion, and a second connection member that connects the piezoelectric film to the frame-shaped member. Of the connection members, the first connection member is disposed between the center of gravity of the vibration portion and the second connection member.

Abstract: Provided is a tobacco sheet having high swelling property for a non-combustion heating type flavor inhaler. The tobacco sheet for a non-combustion heating type flavor inhaler includes tobacco powder having a cumulative 90% particle size (D90) of 200 ?m or more in a volume-based particle size distribution measured by a dry laser diffraction method.

Abstract: Provided is an efficient method for attaching a tissue section. In the invention, one of problems is solved by changing attachment conditions of the tissue section depending on an organ from which the tissue section is derived. A technique of achieving good adhesiveness between a microscope slide and a section by introducing unevenness on a front surface of the microscope slide using reactive ion etching as one of the attachment conditions is provided. Further, a technique of optimizing the attachment of the section using a machine learning technique or the like is provided.

Abstract: A light emitting module including: a light guide member including: an emission region defined by a sectioning groove, a light source placement part located in the emission region, and a light adjusting hole; and a light source disposed in the light source placement part. In the schematic top view: the light adjusting hole is not positioned on a first straight line connecting (i) a center of the light source and (ii) a point in the sectioning groove that is farthest from the center of the light source, and a first lateral face of the light adjusting hole has a first region, and a line normal to the first region is oblique to a second straight line connecting (i) the center of the light source and (ii) a point in the sectioning groove that is closest to the center of the light source.

Abstract: The method of manufacturing a light emitting module includes: providing a light guiding plate having a first main surface serving as a light emitting surface; and a second main surface positioned opposite to the first main surface and provided with a recess; providing a light adjustment portion containing a fluorescent material; providing a light emitting element unit in which a light emitting element comprising an electrode is integrally bonded to the light adjustment portion; bonding the light adjustment portion of the light emitting element unit to the recess; and forming wiring on the electrode of the light emitting element.

Abstract: The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine A2 receptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine A2 receptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine A2 receptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Abstract: A light emitting module includes: a light guide member including: an emission region defined by a sectioning groove, a light source placement part located in the emission region, and a light adjusting hole that, in a schematic top view, is located between the sectioning groove and the light source placement part; and a light source disposed in the light source placement part. A refractive index of an inside of the light adjusting hole is lower than a refractive index of the light guide member. In the schematic top view, the light adjusting hole is positioned to intersect with a first straight line connecting a center of the light source and a farthest point in the sectioning groove, the farthest point being farthest from the center of the light source.

Abstract: A light-emitting module includes first and second light sources, first and second light guide parts, and a first light-modulating member. The first light guide part includes a first A-major surface, a first B-major surface, a first side surface positioned between the first A-major surface and the first B-major surface, and a first hole portion in which the first light source is disposed. The second light guide part includes a second A-major surface, a second B-major surface, a second side surface positioned between the second A-major surface and the second B-major surface, the second side surface facing the first side surface, and a second hole portion in which the second light source is disposed. The first light-modulating member is positioned at an upper side of the first A-major surface. The first light-modulating member overlaps the first A-major surface and the first side surface when viewed in top-view.

Abstract: A light-emitting module includes a light source part, a light-transmitting member including a first light-transmitting part and a second light-transmitting part, the second light-transmitting part is positioned at an upper side of the light source part and the first light-transmitting part, and a light-adjusting member located at an upper side of the light source part, the first light-transmitting part, and the second light-transmitting part, wherein the first light-transmitting part contacts a lateral surface of the light source part, the light-adjusting member includes a through-hole positioned away from the light source part in a plan view, the light-transmitting member includes a recess communicating with the through-hole, and at least a portion of the recess is positioned lower than a lower surface of the light-adjusting member.

Abstract: A planar light source includes a light guide member having a through hole, a light source, a first light adjusting member, a second light adjusting member, and a light transmissive member. The first light adjusting member having reflectivity and transmissivity with respect to light from the light source is disposed on or above an upper face of the light source in the through hole. The second light adjusting member having reflectivity and transmissivity with respect to the light from the light source is disposed above and apart from the first light adjusting member. The first light transmissive member having a higher transmissivity with respect to the light from the light source than the transmissivities of the first and second light adjusting members is disposed between the first light adjusting member and the second light adjusting member, and between a lateral face of the light source and the light guide member.

Abstract: The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine A2 receptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine A2 receptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine A2 receptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Abstract: A light emitting device includes a light emitting element, a light guide member, a reflecting member, a wavelength conversion member. The light emitting element has a light emitting surface and lateral surfaces. The light guiding member is provided on at least a portion of the lateral surfaces of the light emitting element. The reflecting member is provided on the lateral surface of the light emitting element with the light guiding member interposed therebetween. The wavelength conversion member is provided on the light emitting surface of the light emitting element, the light guiding member and the reflecting member. The wavelength conversion member is provided with a recess between an outer lateral surface of the wavelength conversion member and the light guiding member. The reflecting member is provided in the recess.

Abstract: A light emitting module includes: a light source part including a first light source and a second light source; a light guide member including: a first light guide part having a 1st A principal face, a 1st B principal face located opposite to the 1st A principal face, a first lateral face positioned between the 1st A principal face and the 1st B principal face, and a first hole in which the first light source is disposed; and a second light guide part having a 2nd A principal face, a 2nd B principal face located opposite to the 2nd A principal face, a second lateral face positioned between the 2nd A principal face and the 2nd B principal face, the second lateral face facing the first lateral face, and a second hole in which the second light source is disposed.

Abstract: A method for manufacturing a planar light source includes: preparing a structure body including a wiring substrate, a light guide plate including a first major surface, a second major surface, and an inner side surface defining a first hole with an opening on a first major surface side, and a light source arranged on the wiring substrate in the first hole; injecting a first resin material downward through the opening of the first hole, the first resin material including a light-diffusing agent; and curing the first resin material to form a first resin layer on a wiring substrate between the inner side surface of the first hole and a first side surface of a first light-transmitting member.

Abstract: The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine A2 receptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine A2 receptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine A2 receptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Abstract: A method of manufacturing a light emitting module includes: providing an intermediate that includes a light guide having a first principal face and a second principal face opposing the first principal face, a plurality of light sources disposed on the second principal face of the light guide, and a wiring layer disposed on the second principal face and electrically connected to the plurality of light sources; allowing the plurality of light sources to emit light and measuring optical characteristics of the emitted light; and forming an optical characteristic correcting element in the intermediate based on the measured optical characteristics.

Abstract: A light emitting device includes a light emitting element, a light guide member, a reflecting member, a wavelength conversion member. The light emitting element has a light emitting surface and lateral surfaces. The light guiding member is provided on at least a portion of the lateral surfaces of the light emitting element. The reflecting member is provided on the lateral surface of the light emitting element with the light guiding member interposed therebetween. The wavelength conversion member is provided on the light emitting surface of the light emitting element, the light guiding member and the reflecting member. The wavelength conversion member is provided with a recess between an outer lateral surface of the wavelength conversion member and the light guiding member. The reflecting member is provided in the recess.

Abstract: A method for manufacturing a planar light source includes preparing a wiring substrate including a first region that includes a light source placement section; disposing a light-reflective member in the first region of the wiring substrate; preparing a light guide plate including a first major surface, a second major surface opposite to the first major surface, and a first hole extending from the first major surface to the second major surface; disposing a light source on the light-reflective member at the light source placement section; disposing the light guide plate on the wiring substrate to cause the wiring substrate and the second major surface of the light guide plate to face each other to cause the light source to be positioned in the first hole; and disposing a first light-transmitting member in the first hole.

Abstract: A light emitting module includes at least one light source, a light guide member having a demarcating groove configured to demarcate at least one light emitting region, and at least one light source arrangement part located in each of the at least one light emitting region and accommodating a light source, a first light-reflecting member disposed in the demarcating groove, and a wavelength converting member covering an upper surface of the light guide member.