Patents by Inventor Toru Yoshizawa
Toru Yoshizawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11723976Abstract: In one non-limiting embodiment, the present disclosure relates to lyophilized formulations containing an IL-31 antagonist (for example, an anti-IL-31RA antibody) as an active ingredient, the lyophilized formulations further containing arginine and/or a salt thereof and sucrose and/or trehalose. In another non-limiting embodiment, the present disclosure relates to solution formulations containing an IL-31 antagonist as an active ingredient, the solution formulations further containing arginine and/or a salt thereof.Type: GrantFiled: January 12, 2022Date of Patent: August 15, 2023Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Daisuke Kameoka, Toru Yoshizawa, Megumi Numata, Hitoshi Sasaki, So Yamaguchi, Hiroko Murata, Naoka Hironiwa
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Publication number: 20220184210Abstract: In one non-limiting embodiment, the present disclosure relates to lyophilized formulations containing an IL-31 antagonist (for example, an anti-IL-31RA antibody) as an active ingredient, the lyophilized formulations further containing arginine and/or a salt thereof and sucrose and/or trehalose. In another non-limiting embodiment, the present disclosure relates to solution formulations containing an IL-31 antagonist as an active ingredient, the solution formulations further containing arginine and/or a salt thereof.Type: ApplicationFiled: March 4, 2022Publication date: June 16, 2022Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Daisuke Kameoka, Toru Yoshizawa, Megumi Numata, Hitoshi Sasaki, So Yamaguchi, Hiroko Murata, Naoka Hironiwa
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Publication number: 20220125921Abstract: In one non-limiting embodiment, the present disclosure relates to lyophilized formulations containing an IL-31 antagonist (for example, an anti-IL-31RA antibody) as an active ingredient, the lyophilized formulations further containing arginine and/or a salt thereof and sucrose and/or trehalose. In another non-limiting embodiment, the present disclosure relates to solution formulations containing an IL-31 antagonist as an active ingredient, the solution formulations further containing arginine and/or a salt thereof.Type: ApplicationFiled: January 12, 2022Publication date: April 28, 2022Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Daisuke Kameoka, Toru Yoshizawa, Megumi Numata, Hitoshi Sasaki, So Yamaguchi, Hiroko Murata, Naoka Hironiwa
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Patent number: 11260125Abstract: In one non-limiting embodiment, the present disclosure relates to lyophilized formulations containing an IL-31 antagonist (for example, an anti-IL-31RA antibody) as an active ingredient, the lyophilized formulations further containing arginine and/or a salt thereof and sucrose and/or trehalose. In another non-limiting embodiment, the present disclosure relates to solution formulations containing an IL-31 antagonist as an active ingredient, the solution formulations further containing arginine and/or a salt thereof.Type: GrantFiled: June 14, 2021Date of Patent: March 1, 2022Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Daisuke Kameoka, Toru Yoshizawa, Megumi Numata, Hitoshi Sasaki, So Yamaguchi, Hiroko Murata, Naoka Hironiwa
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Publication number: 20210322550Abstract: In one non-limiting embodiment, the present disclosure relates to lyophilized formulations containing an IL-31 antagonist (for example, an anti-IL-31RA antibody) as an active ingredient, the lyophilized formulations further containing arginine and/or a salt thereof and sucrose and/or trehalose. In another non-limiting embodiment, the present disclosure relates to solution formulations containing an IL-31 antagonist as an active ingredient, the solution formulations further containing arginine and/or a salt thereof.Type: ApplicationFiled: June 14, 2021Publication date: October 21, 2021Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Daisuke Kameoka, Toru Yoshizawa, Megumi Numata, Hitoshi Sasaki, So Yamaguchi, Hiroko Murata, Naoka Hironiwa
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Patent number: 10213319Abstract: CT images near the pelvis are obtained before surgery, and a three-dimensional model of a pelvis part is created on a computer. The virtual three-dimensional bone model is used to plan an installation position of a guide instrument etc., and a virtual three-dimensional surgical site model including the guide instrument is constructed. Subsequently, during surgery, the guide instrument is installed, and three-dimensional images of a surgical site are obtained, and a measured three-dimensional surgical site model including the guide instrument is obtained. The virtual three-dimensional surgical site model and the measured three-dimensional surgical site model are compared, and an error between an ideal installation position of the guide instrument and an actual installation position of the guide instrument is detected to guide the operator to reduce the error.Type: GrantFiled: August 10, 2013Date of Patent: February 26, 2019Assignees: ARTHRODESIGN, LTD., LEXI CO., LTD., SAITAMA MEDICAL UNIVERSITYInventors: Toshitaka Wakayama, Yukari Kito, Norio Seitoku, Takashi Handa, Toru Yoshizawa
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Patent number: 9612449Abstract: An axially symmetric polarization conversion element that converts incident light into an axially symmetric polarized beam includes a reflection section having a shape obtained by rotating the cross section of a Fresnel rhomb wave plate along the direction of an optical axis around an axis that is parallel to the optical axis. The axially symmetric polarization conversion element converts the incident light into an axially symmetric polarized beam by utilizing two Fresnel reflections by the reflection section.Type: GrantFiled: February 7, 2013Date of Patent: April 4, 2017Assignees: Saitama Medical University, Utsunomiya UniversityInventors: Toshitaka Wakayama, Toru Yoshizawa, Yukitoshi Otani
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Publication number: 20150157468Abstract: CT images near the pelvis are obtained before surgery, and a three-dimensional model of a pelvis part is created on a computer. The virtual three-dimensional bone model is used to plan an installation position of a guide instrument etc., and a virtual three-dimensional surgical site model including the guide instrument is constructed. Subsequently, during surgery, the guide instrument is installed, and three-dimensional images of a surgical site are obtained, and a measured three-dimensional surgical site model including the guide instrument is obtained. The virtual three-dimensional surgical site model and the measured three-dimensional surgical site model are compared, and an error between an ideal installation position of the guide instrument and an actual installation position of the guide instrument is detected to guide the operator to reduce the error.Type: ApplicationFiled: August 10, 2013Publication date: June 11, 2015Inventors: Toshitaka Wakayama, Yukari Kito, Norio Seitoku, Takashi Handa, Toru Yoshizawa
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Publication number: 20150002934Abstract: An axially symmetric polarization conversion element that converts incident light into an axially symmetric polarized beam includes a reflection section having a shape obtained by rotating the cross section of a Fresnel rhomb wave plate along the direction of an optical axis around an axis that is parallel to the optical axis. The axially symmetric polarization conversion element converts the incident light into an axially symmetric polarized beam by utilizing two Fresnel reflections by the reflection section.Type: ApplicationFiled: February 7, 2013Publication date: January 1, 2015Inventors: Toshitaka Wakayama, Toru Yoshizawa, Yukitoshi Otani
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Publication number: 20120083629Abstract: The present invention provides a method for efficiently producing a highly pure fluoroether containing remarkably low concentration of a fluorine-containing alkyl alcohol. The method is suited for scale-up and specifically includes performing countercurrent separation of a crude solution of fluoroether including a fluorine-containing alkyl alcohol as an impurity using water.Type: ApplicationFiled: June 15, 2010Publication date: April 5, 2012Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Michiru Kagawa, Aoi Nakazono, Yasuhide Senba, Hitoshi Motoyama, Toru Yoshizawa, Meiten Koh
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Patent number: 6906809Abstract: A grating (3) is disposed to face the measurement target surface of a measurement target object (11). A light source (1) irradiates the grating (3) with illumination light. A camera (6) captures a moire fringe image formed on the grating (3) by light passing through the grating 3 and reflected by the measurement target surface. A moving means (9) changes the distance (H) between the grating 3 and the measurement target surface. An analyzing means (8) performs an analysis process of obtaining 3-D shape information of the measurement target surface from the image picked up by the camera (6) in at least two cases in which the distance (H) is set to different values, and obtains, on the basis of the 3-D shape information in each case and the distance H, true 3-D shape information from which the measurement error caused by the inclination of the measurement target surface is eliminated.Type: GrantFiled: July 12, 2001Date of Patent: June 14, 2005Assignee: Yamatake CorporationInventors: Hisatoshi Fujiwara, Toru Yoshizawa, Yukitoshi Otani
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Patent number: 6665059Abstract: A measuring method capable of automatically analyzing quantitatively the inner state of a disk is provided. Linearly polarized light from a light source enters a retarder to produce a desired elliptically polarized state. The elliptically polarized light is then passed through a half-wave plate to rotate the direction of a principal axis of the ellipse. The light is expanded into two dimensions by lens systems and to obtain planar information, and is further transmitted through a disk substrate so that the birefringence of a specimen, which depends on an inner stress state and a polymer orientation state, changes the phase of the light. The light wave with its phase changed is passed through a polarizer arranged perpendicular to the principal axis of the retarder. The CCD detects the light wave as a light intensity.Type: GrantFiled: February 13, 2001Date of Patent: December 16, 2003Assignee: Fuji Electric Co., Ltd.Inventors: Toshiyuki Kanno, Eiji Ishibashi, Toru Yoshizawa, Yukitoshi Otani
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Publication number: 20030179385Abstract: A grating (3) is disposed to face the measurement target surface of a measurement target object (11). A light source (1) irradiates the grating (3) with illumination light. A camera (6) captures a moire fringe image formed on the grating (3) by light passing through the grating 3 and reflected by the measurement target surface. A moving means (9) changes the distance (H) between the grating 3 and the measurement target surface. An analyzing means (8) performs an analysis process of obtaining 3-D shape information of the measurement target surface from the image picked up by the camera (6) in at least two cases in which the distance (H) is set to different values, and obtains, on the basis of the 3-D shape information in each case and the distance H, true 3-D shape information from which the measurement error caused by the inclination of the measurement target surface is eliminated.Type: ApplicationFiled: May 15, 2003Publication date: September 25, 2003Inventors: Hisatoshi Fujiwara, Toru Yoshizawa, Yukitoshi Otani
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Patent number: 6392105Abstract: The invention provide a method for producing a fluoroalcohol of the following formula (1): H(CFR1CF2)nCH2OH (1) (wherein R1 represents F or CF3, when n=1; R1 represents F, when n=2) comprising reacting methanol with tetrafluoroethylene or hexafluoropropylene in the presence of a free radical source, wherein the reaction mixture is subjected to distillation either in the presence of a base or after contact of said reaction mixture with a base.Type: GrantFiled: September 1, 1999Date of Patent: May 21, 2002Assignee: Daikin Industries, Ltd.Inventors: Toru Yoshizawa, Shoji Takaki, Takashi Yasuhara, Yasunori Yokoyama
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Publication number: 20010028451Abstract: A measuring method capable of automatically analyzing quantitatively the inner state of a disk is provided. Linearly polarized light from a light source enters a retarder to produce a desired elliptically polarized state. The elliptically polarized light is then passed through a half-wave plate to rotate the direction of a principal axis of the ellipse. The light is expanded into two dimensions by lens systems and to obtain planar information, and is further transmitted through a disk substrate so that the birefringence of a specimen, which depends on an inner stress state and a polymer orientation state, changes the phase of the light. The light wave with its phase changed is passed through a polarizer arranged perpendicular to the principal axis of the retarder. The CCD detects the light wave as a light intensity.Type: ApplicationFiled: February 13, 2001Publication date: October 11, 2001Inventors: Toshiyuki Kanno, Eiji Ishibashi, Toru Yoshizawa, Yukitoshi Otani
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Patent number: 6294704Abstract: The invention relates to a method for manufacturing a fluoroalcohol represented by formula (1) H(CFR1CF2)nCH2OH (1) (wherein R1 represents F or CF3, when n=1; R1 represents F, when n=2) by reacting methanol with tetrafluoroethylene or hexafluoropropylene in the presence of a free radical generator, wherein the method comprises the steps of: feeding a reaction mixture into a distillation column; distilling off methanol from the top of the distillation column; withdrawing a bottom fraction comprising the fluoroalcohol from the bottom of the distillation column; removing a fraction comprising water and HF from the distillation column by side cut; feeding methanol from the top of the distillation column back into a reactor for recycling; and purifying the bottom fraction to recover the fluoroalcohol represented by formula (1).Type: GrantFiled: September 13, 1999Date of Patent: September 25, 2001Assignee: Daikin Industries, Ltd.Inventors: Shoji Takaki, Toru Yoshizawa
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Patent number: 6187969Abstract: A process for producing a fluoroalcohol of the following formula (1) H(CFR1CF2)nCH2OH (1) (n=1 or 2, wherein R1 represents F or CF3 when n=1; R1 represents F when n=2) comprising reacting methanol with tetrafluoroethylene or hexafluoropropylene in the presence of an initiator wherein the fluoroalcohol of formula (1) is distilled after decomposing the remaining initiator contained in the reaction mixture.Type: GrantFiled: September 13, 1999Date of Patent: February 13, 2001Assignee: Daikin Industries, Ltd.Inventors: Fumihiko Yamaguchi, Shoji Takaki, Toru Yoshizawa, Eiji Ogura, Toshiyuki Katsube
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Patent number: 5304654Abstract: A 2-nitroimidazole compound of the formula: ##STR1## wherein R.sub.f is a fluorine-containing organic group which has at least one fluorine atom on a carbon atom which bonds to the nitrogen atom of the imidazole ring or a carbon atom which bonds to said carbon atom and a radiosensitizer comprising said nitroimidazole derivative.Type: GrantFiled: September 9, 1991Date of Patent: April 19, 1994Assignees: Yasunori Nishijima, Daikin Industries, Ltd.Inventors: Tsutomu Kagiya, Mitsuyuki Abe, Seiichi Nishimoto, Yuta Shibamoto, Kazuhiro Shimokawa, Yorisato Hisanaga, Tatsuo Nakada, Toru Yoshizawa
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Patent number: 4977273Abstract: A 2-nitroimidazole derivative of the formula: ##STR1## wherein R.sub.f is a group of the following formula (II) or (III):--CH.sub.2 CFXCH.sub.2 OR.sub.1 (II)wherein X is a hydrogen atom or a halogen atom; R.sub.1 is a group of the formula: ##STR2## wherein R.sub.2 is a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.3 alkyl group, a C.sub.2 -C.sub.4 acyl group, benzylidene or acetonide; R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; Z is a hydrogen atom, COOY, COOR.sub.3, CONHOY, CONR.sub.4 R.sub.5 (wherein R.sub.4 and R.sub.5 are hydroxyl group-containing C.sub.1 -C.sub.3 alkyl groups or hydrogen atoms; Y is a hydrogen atom or a monovalent metal atom), an amino group, a hydroxyl group or OR.sub.3 ; l is an integer of 1 to 3; o is an integer of 0 to 3; p is an integer of 0 to 2; q is an integer of 0 to 3; m and n are integers of 0 to 4; and 1.ltoreq.m+n.ltoreq.4 or ##STR3## wherein R.sub.3, X and p are the same as defined above; Z' is the same as Z or is OCOOCH.sub.Type: GrantFiled: December 12, 1989Date of Patent: December 11, 1990Assignees: Kyoto University of Honmachi, Taisho Pharmaceutical Co., Ltd., Daikin Industries, Ltd.Inventors: Tsutomu Kagiya, Mitsuyuki Abe, Seiichi Nishimoto, Yuta Shibamoto, Susumu Otomo, Tohru Tanami, Kazuhiro Shimokawa, Toru Yoshizawa, Yorisato Hisanaga
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Patent number: 4927941Abstract: A nitroazole derivative of the formula:NA--R.sub.f (I)wherein NA is 3-nitro-1,2,4-triazol-l-yl and R.sub.f is a fluorine-containing organic group which is useful as a radiosensitizer.Type: GrantFiled: June 9, 1988Date of Patent: May 22, 1990Assignee: Yasunori Nishijima & Daikin Industries Ltd.Inventors: Tsutomu Kagiya, Mitsuyuki Abe, Seiichi Nishimoto, Yuta Shibamoto, Kazuhiro Shimokawa, Yorisato Hisanaga, Tatsuo Nakada, Toru Yoshizawa