Abstract: To provide a novel compound or a salt thereof or a solvate thereof, having a CSF-1R inhibitory activity and exhibiting antitumor effect. An azaindole derivative of formula (I): wherein A represents a C6-10 aryl ring, an aromatic heterocycle, or an unsaturated heterocycle, and A optionally has one substituent or more same or different substituents; and R represents a C1-3 alkyl group or a saturated heterocyclic group, or a salt thereof or a solvate thereof.

Abstract: To provide a sheet formed product that, in addition to being thin, has a small groove interval, groove width, and groove depth, that has a large contact surface area with oxygen gas or hydrogen gas, that is suitable for simply and at low cost producing a lightweight compact separator, and a manufacturing method for same. In the sheet formed product (amorphous thin sheet) according to the present invention, a metal matrix on which is formed a passivation layer on a surface layer thereof and that exhibits corrosion resistance has a three-dimensional surface structure, for example a groove-like uneven shape on a surface thereof. On the front surface having the uneven shape (or also on the back surface), particles of a conductive material component penetrate the passivation layer, and are exposed on the surface without being in solid solution in the metal matrix.

Abstract: [Problem] To provide a corrosion-resistant coating that exhibits greater corrosion protection in saltwater environments and the like than was conventional, a method for forming the same, and a device for forming the same. [Solution] A corrosion-resistant alloy coating is formed on a substrate surface by: a) using a thermal spray gun, having a function wherein a flame including melted material particles is jetted toward a substrate, and the flame is partitioned from the open air in an upstream region on said jet path (which is to say the region in which the material particles are melted), and a function wherein, in a downstream region (the area continuing from the upstream region), the material particles and the flame are forcibly cooled by a jet-gas or jet-mist before reaching the substrate; and b) using a corrosion-resistant alloy material comprising aluminum, for the material particles.

Abstract: [Problem] To provide a corrosion-resistant coating that exhibits greater corrosion protection in saltwater environments and the like than was conventional, a method for forming the same, and a device for forming the same. [Solution] A corrosion-resistant alloy coating is formed on a substrate surface by: a) using a thermal spray gun, having a function wherein a flame including melted material particles is jetted toward a substrate, and the flame is partitioned from the open air in an upstream region on said jet path (which is to say the region in which the material particles are melted), and a function wherein, in a downstream region (the area continuing from the upstream region), the material particles and the flame are forcibly cooled by a jet-gas or jet-mist before reaching the substrate; and b) using a corrosion-resistant alloy material comprising aluminum, for the material particles.

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin.

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin.

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin.

Abstract: The present invention relates to provision of a novel compound that has an activity of promoting insulin secretion from pancreatic ? cells and thus is useful as a prophylaxis and/or therapeutic agent for diseases caused by hyperglycemia such as diabetes mellitus, and the compound represented by the following formula (1): wherein one of A and B represents a nitrogen atom and the other represents a nitrogen atom or CR10, X represents an oxygen atom, a sulfur atom or —(CH2)n-N(R12)—, Y represents an oxygen atom, a sulfur atom or —N(R13)—, and R1 to R9 each represent a hydrogen atom or another substituent, or a salt thereof, or a solvate of the compound or the salt.

Abstract: The present invention provides a low molecular weight compound having EPO production-promoting action and/or hemoglobin production-promoting action. The present invention relates to a fused piperidine compound represented by the following general formula (1): (wherein, ring A represents a C10-14 aryl group or 5- to 10-membered heterocyclic group, X represents N—R7, a sulfur atom or an oxygen atom, R1, R2, R2?, R3 and R3? independently represent a hydrogen atom, C1-6 alkyl group or C3-6 cycloalkyl group, and R4, R5 and R6 independently represent a hydrogen atom or halogen atom), or a salt thereof, or a solvate thereof.

Abstract: The present invention relates to provision of a novel compound that has an activity of promoting insulin secretion from pancreatic ? cells and thus is useful as a prophylaxis and/or therapeutic agent for diseases caused by hyperglycemia such as diabetes mellitus, and the compound represented by the following formula (1): wherein one of A and B represents a nitrogen atom and the other represents a nitrogen atom or CR10, X represents an oxygen atom, a sulfur atom or —(CH2)n-N(R12)—, Y represents an oxygen atom, a sulfur atom or —N(R13)—, and R1 to R9 each represent a hydrogen atom or another substituent, or a salt thereof, or a solvate of the compound or the salt.

Abstract: The present invention provides a low molecular weight compound having EPO production-promoting action and/or hemoglobin production-promoting action. The present invention relates to a fused piperidine compound represented by the following general formula (1): (wherein, ring A represents a C10-14 aryl group or 5- to 10-membered heterocyclic group, X represents N—R7, a sulfur atom or an oxygen atom, R1, R2, R2?, R3 and R3? independently represent a hydrogen atom, C1-6 alkyl group or C3-6 cycloalkyl group, and R4, R5 and R6 independently represent a hydrogen atom or halogen atom), or a salt thereof, or a solvate thereof.

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin.

Abstract: Disclosed is a low-molecular-weight compound having an EPO production-promoting activity and/or a hemoglobin expression-enhancing activity. Specifically disclosed is an EPO production promoter and/or a hemoglobin expression enhancer comprising a 1-acyl-4-(phenoxy, benzyloxy or phenylamino)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by the general formula (1); [wherein R1, R2, R2?, R3 and R3? independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11 or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

Abstract: The hot rolling apparatus of the present invention has a mill arranged on the preceding stage, mills of a plurality of stands arranged on the later stage which are different-diameter roll mills including a pair of different-diameter work rolls having an equivalent roll diameter of less than 600 mm or minimum-diameter roll mills including a pair of work rolls having a diameter of less than 600 mm, and a cooling unit for cooling steel to be rolled which is arranged on each exit side of the mills of at least two stands on the later stage. The hot rolling apparatus can smoothly manufacture hot rolled plates of fine-particle steel.

Abstract: The hot rolling apparatus of the present invention has a mill arranged on the preceding stage, mills of a plurality of stands arranged on the later stage which are different-diameter roll mills including a pair of different-diameter work rolls having an equivalent roll diameter of less than 600 mm or minimum-diameter roll mills including a pair of work rolls having a diameter of less than 600 mm, and a cooling unit for cooling steel to be rolled which is arranged on each exit side of the mills of at least two stands on the later stage. The hot rolling apparatus can smoothly manufacture hot rolled plates of fine-particle steel.