Patents by Inventor Toshihiko Murayama

Toshihiko Murayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic agent for fibrosis and inhibitor of nuclear translocation of phosphorylated Smad
    Patent number: 10980789
    Abstract: A therapeutic agent for fibrosis, whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, inhibits the nuclear translocation of phosphorylated Smad, thereby treating and preventing fibrosis.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: April 20, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hiroyuki Nakamura, Toshihiko Murayama
  • THERAPEUTIC AGENT FOR FIBROSIS AND INHIBITOR OF NUCLEAR TRANSLOCATION OF PHOSPHORYLATED SMAD
    Publication number: 20200061038
    Abstract: A therapeutic agent for fibrosis, whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, inhibits the nuclear translocation of phosphorylated Smad, thereby treating and preventing fibrosis.
    Type: Application
    Filed: October 23, 2019
    Publication date: February 27, 2020
    Inventors: Hiroyuki NAKAMURA, Toshihiko MURAYAMA
  • Therapeutic agent for fibrosis and inhibitor of nuclear translocation of phosphorylated smad
    Patent number: 10478427
    Abstract: A therapeutic agent for fibrosis, whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, inhibits the nuclear translocation of phosphorylated Smad, thereby treating and preventing fibrosis.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: November 19, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hiroyuki Nakamura, Toshihiko Murayama
  • THERAPEUTIC AGENT FOR FIBROSIS AND INHIBITOR OF NUCLEAR TRANSLOCATION OF PHOSPHORYLATED SMAD
    Publication number: 20180008585
    Abstract: A therapeutic agent for fibrosis, whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, inhibits the nuclear translocation of phosphorylated Smad, thereby treating and preventing fibrosis.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 11, 2018
    Inventors: Hiroyuki NAKAMURA, Toshihiko MURAYAMA
  • Ceramide derivative and Golgi apparatus-labeling fluorescent probe using same
    Patent number: 9207232
    Abstract: A measure for selective fluorescent labeling of the Golgi apparatus, which has low cytotoxicity and excellent intracellular stability, is provided. According to the present invention, provided are a ceramide derivative represented by the following Chemical formula 1: in the formula, R1 is an alkyl group having 1 to 12 carbon atoms, R2 is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 1 to 20, and a Golgi apparatus-labeling fluorescent probe using the same.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: December 8, 2015
    Assignee: National University Corporation Chiba University
    Inventors: Atsushi Nishida, Hiroyuki Nakamura, Tomohiko Makiyama, Toshihiko Murayama
  • CERAMIDE DERIVATIVE AND GOLGI APPARATUS-LABELING FLUORESCENT PROBE USING SAME
    Publication number: 20140329266
    Abstract: A measure for selective fluorescent labeling of the Golgi apparatus, which has low cytotoxicity and excellent intracellular stability, is provided. According to the present invention, provided are a ceramide derivative represented by the following Chemical formula 1: in the formula, R1 is an alkyl group having 1 to 12 carbon atoms, R2 is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 1 to 20, and a Golgi apparatus-labeling fluorescent probe using the same.
    Type: Application
    Filed: August 13, 2012
    Publication date: November 6, 2014
    Applicant: National University Corporation Chiba University
    Inventors: Atsushi Nishida, Hiroyuki Nakamura, Tomohiko Makiyama, Toshihiko Murayama