Patents by Inventor Toshihiko Naito
Toshihiko Naito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11359588Abstract: In a fuel supply device including a regulator and float-type level sensor, a fitting tube is formed integrally with an upper housing, a fuel pump being retained between the upper and lower housings. An outer periphery of a base part of the regulator is fitted into the tube. A regulator retaining member is formed as a separate member from the upper housing and retains the regulator in cooperation with the tube. The tube and the retaining member are joined via a snap-fit join part provided on fitting parts therebetween. The snap-fit join part is formed by engaging a projecting portion or a recess part, formed on an elastic piece provided on one of the fitting parts between the retaining member and the tube, with the recess part or the projecting portion formed on the other fitting part. A sensor support arm is molded as a unit with the retaining member.Type: GrantFiled: March 17, 2021Date of Patent: June 14, 2022Assignee: Hitachi Astemo Ltd.Inventors: Toshihiko Naito, Yuki Fukuda
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Publication number: 20210300175Abstract: In a fuel supply device including a regulator and float-type level sensor, a fitting tube is formed integrally with an upper housing, a fuel pump being retained between the upper and lower housings. An outer periphery of a base part of the regulator is fitted into the tube. A regulator retaining member is formed as a separate member from the upper housing and retains the regulator in cooperation with the tube. The tube and the retaining member are joined via a snap-fit join part provided on fitting parts therebetween. The snap-fit join part is formed by engaging a projecting portion or a recess part, formed on an elastic piece provided on one of the fitting parts between the retaining member and the tube, with the recess part or the projecting portion formed on the other fitting part. A sensor support arm is molded as a unit with the retaining member.Type: ApplicationFiled: March 17, 2021Publication date: September 30, 2021Inventors: Toshihiko NAITO, Yuki FUKUDA
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Patent number: 8646480Abstract: A fuel supply apparatus or fuel pump unit includes a lower case having a flange plate fixed to a fuel tank and upstanding walls extending into the fuel tank. An upper case housing a fuel pump therein is provided that includes brackets disposed along inner sides of the upstanding walls. The upstanding walls having engaging holes defined therein, and the brackets having attachment members engaging in the engaging holes. The brackets include tongues projecting heightwise beyond the upstanding walls.Type: GrantFiled: June 27, 2011Date of Patent: February 11, 2014Assignees: Honda Motor Co., Ltd., Keihin CorporationInventors: Shinya Koyama, Kyohei Hosoya, Kuniharu Kimura, Junji Miyazaki, Hikaru Tsukamoto, Toshihiko Naito
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Patent number: 8058474Abstract: A process for preparing a compound (C) represented by the following formula: wherein R1 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl, and R2 represents hydrogen or methoxy, characterized by reacting a compound (A-1) represented by the following formula: wherein R1 has the same definition as above, with a compound (B) represented by the following formula: wherein R2 has the same definition as above, and L represents a leaving group, is provided. Compound (C) is effective for prevention or treatment of various diseases associated with angiogenesis neoplasia.Type: GrantFiled: March 9, 2009Date of Patent: November 15, 2011Assignee: Eisai R&D Management Co., Ltd.Inventor: Toshihiko Naito
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Patent number: 7683172Abstract: A process for preparing a compound (C) represented by the following formula: wherein R1 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl, and R2 represents hydrogen or methoxy, characterized by reacting a compound (A-1) represented by the following formula: wherein R1 has the same definition as above, with a compound (B) represented by the following formula: wherein R2 has the same definition as above, and L represents a leaving group, is provided. Compound (C) is effective for prevention or treatment of various diseases associated with angiogenesis neoplasia.Type: GrantFiled: November 8, 2004Date of Patent: March 23, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Toshihiko Naito, Kazuhiro Yoshizawa
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Publication number: 20090171112Abstract: A process for preparing a compound (C) represented by the following formula: wherein R1 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl, and R2 represents hydrogen or methoxy, characterized by reacting a compound (A-1) represented by the following formula: wherein R1 has the same definition as above, with a compound (B) represented by the following formula: wherein R2 has the same definition as above, and L represents a leaving group, is provided. Compound (C) is effective for prevention or treatment of various diseases associated with angiogenesis neoplasia.Type: ApplicationFiled: March 9, 2009Publication date: July 2, 2009Inventors: Toshihiko Naito, Kazuhiro Yoshizawa
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Publication number: 20090163715Abstract: A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R1 and R2 independently represent hydrogen or a protecting group for an amino group, or R1 and R2 bond together to form an optionally substituted pyrrole ring.Type: ApplicationFiled: May 25, 2006Publication date: June 25, 2009Applicant: EISAI R&D MANAGEMENT CO., LTD.Inventors: Mitsuo Nagai, Kazumasa Nara, Kazunori Wakasugi, Toshihiko Naito
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Publication number: 20070037849Abstract: A process for preparing a compound (C) represented by the following formula: wherein R1 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl, and R2 represents hydrogen or methoxy, characterized by reacting a compound (A-1) represented by the following formula: wherein R1 has the same definition as above, with a compound (B) represented by the following formula: wherein R2 has the same definition as above, and L represents a leaving group, is provided. Compound (C) is effective for prevention or treatment of various diseases associated with angiogenesis neoplasia.Type: ApplicationFiled: November 8, 2004Publication date: February 15, 2007Inventors: Toshihiko Naito, Kazuhiro Yoshizawa
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Patent number: 6841549Abstract: The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g.Type: GrantFiled: June 30, 2000Date of Patent: January 11, 2005Assignee: Eisai Co., Ltd.Inventors: Osamu Asano, Hitoshi Harada, Seiji Yoshikawa, Nobuhisa Watanabe, Takashi Inoue, Tatsuo Horizoe, Nobuyuki Yasuda, Kaya Ohashi, Hiroe Minami, Junsaku Nagaoka, Manabu Murakami, Seiichi Kobayashi, Isao Tanaka, Tsutomu Kawata, Naoyuki Shimomura, Hiroshi Akamatsu, Naoki Ozeki, Toshikazu Shimizu, Kenji Hayashi, Toyokazu Haga, Shigeto Negi, Toshihiko Naito
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Patent number: 5792781Abstract: A compound represented by the general formula: ##STR1## wherein R.sup.1 and R.sup.2 denote a halogen atom or hydrogen atom; R.sup.3 means a hydrogen atom or lower alkyl group; l, r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for --S--, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmaceutical composition suitable for use as an antifungal agent.Type: GrantFiled: September 18, 1996Date of Patent: August 11, 1998Assignee: Eisai Co., Ltd.Inventors: Toshihiko Naito, Katsura Hata, Yumiko Kaku, Akihiko Tsuruoka, Itaru Tsukada, Manabu Yanagisawa, Toshio Toyosawa, Kazumasa Nara
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Patent number: 5789429Abstract: A compound represented by the general formula: ##STR1## wherein R.sup.1 and R.sup.2 denote a halogen atom or hydrogen atom; R.sup.3 means a hydrogen atom or lower alkyl group; l, r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for --S--, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.Type: GrantFiled: March 3, 1997Date of Patent: August 4, 1998Assignee: Eisai Co., Ltd.Inventors: Toshihiko Naito, Katsura Hata, Yumiko Kaku, Akihiko Tsuruoka, Itaru Tsukada, Manabu Yanagisawa, Toshio Toyosawa, Kazumasa Nara
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Patent number: 5663414Abstract: A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A.sub.2, so that it is effective in the treatment of diseases for which such an activity is efficacious.Type: GrantFiled: December 29, 1995Date of Patent: September 2, 1997Assignee: Eisai Co., Ltd.Inventors: Hitoshi Oinuma, Takashi Hasegawa, Tadanobu Takamura, Kenichi Nomoto, Yoshiharu Daiku, Toshihiko Naito, Sachiyuki Hamano
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Patent number: 5648372Abstract: A compound represented by the general formula: ##STR1## wherein R.sup.1 and R.sup.2 denote a halogen atom or hydrogen atom; R.sup.3 means a hydrogen atom or lower alkyl group; l, r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for --S--, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.Type: GrantFiled: February 1, 1995Date of Patent: July 15, 1997Assignee: Eisai Co., Ltd.Inventors: Toshihiko Naito, Katsura Hata, Yumiko Kaku, Akihiko Tsuruoka, Itaru Tsukada, Manabu Yanagisawa, Toshio Toyosawa, Kazumasa Nara
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Patent number: 5530118Abstract: A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A.sub.2, so that it is effective in the treatment of diseases for which such an activity is efficacious.Type: GrantFiled: December 6, 1993Date of Patent: June 25, 1996Assignee: Eisai Co., Ltd.Inventors: Hitoshi Oinuma, Takashi Hasegawa, Tadanobu Takamura, Kenichi Nomoto, Yoshiharu Daiku, Toshihiko Naito, Sachiyuki Hamano
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Patent number: 5373000Abstract: A cephalosporin derivative represented by the formula: ##STR1## wherein R.sub.1 represents a lower alkyl group, and A is selected from: a group of the following formula: ##STR2## where R.sub.2 and R.sub.3 are the same or different lower alkyl group, R.sub.4 represents a substituted lower alkyl or amino group;a group which may be substituted and which is represented by the following formula: ##STR3## where R.sub.5 represents a lower alkyl group; or a group of the following formula: ##STR4## where R.sub.5 is as defined above, R.sub.6 represents a hydroxyl lower alkyl or carboxyl group, or its pharmacologically acceptable salt, and a process for preparing the same, as well as an antibacterial agent containing the same.Type: GrantFiled: April 1, 1992Date of Patent: December 13, 1994Assignee: Eisai Co., Ltd.Inventors: Yoshimasa Machida, Takashi Kamiya, Shigeto Negi, Toshihiko Naito, Yuuki Komatu, Seiichiro Nomoto, Isao Sugiyama, Hiroshi Yamauchi
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Patent number: 5281626Abstract: A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A.sub.2, so that it is effective in the treatment of diseases for which such an activity is efficacious.Type: GrantFiled: September 26, 1991Date of Patent: January 25, 1994Assignee: Eisai Co., Ltd.Inventors: Hitoshi Oinuma, Takashi Hasegawa, Tadanobu Takamura, Kenichi Nomoto, Yoshiharu Daiku, Toshihiko Naito, Sachiyuki Hamano
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Patent number: 5128465Abstract: A cephem derivative represented by the following formula: ##STR1## wherein R.sub.1 means a fluorine-substituted lower alkyl and A.sub.1 denotes a cyclic or acyclic ammonio group, or a non-toxic salt thereof, is prepared by reacting a compound represented by the following formula: ##STR2## wherein A.sub.1 has the same meaning as defined above, with another compound represented by the following formula: ##STR3## wherein R.sub.1 has the same meaning as defined above, and if necessary, removing the protecting groups.Type: GrantFiled: January 22, 1990Date of Patent: July 7, 1992Assignee: Eisai Co., Ltd.Inventors: Takashi Kamiya, Toshihiko Naito, Yuuki Komatu, Yasunobu Kai, Takaharu Nakamura, Manabu Sasho, Shigeto Negi, Isao Sugiyama, Kanemasa Katsu, Hiroshi Yamauchi
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Patent number: 5089491Abstract: A 3-propenylcephem derivative of the following formula: ##STR1## wherein R.sub.1 represents a fluoro-substituted lower alkyl group or a cyano-substituted lower alkyl group, and A represents a cyclic or an acylic ammonio group, or a pharmaceutically acceptable salt thereof, exhibiting excellent anti-bacterial activities against both Gram-positive bacteria and Gram-negative bacteria; Process for the preparation thereof; Anti-bacterial composition; Intermediate for the 3-propenylcephem derivative; and Process for the preparation of the intermediate.Type: GrantFiled: January 11, 1990Date of Patent: February 18, 1992Assignee: Eisai Co., Ltd.Inventors: Takashi Kamiya, Toshihiko Naito, Shigeto Negi, Yuuki Komatu, Yasunobu Kai, Takaharu Nakamura, Isao Sugiyama, Yoshimasa Machida, Seiichiro Nomoto, Kyosuke Kitoh, Kanemasa Katsu, Hiroshi Yamauchi
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Patent number: 5006649Abstract: A 3-propenylcephem derivative of the following formula: ##STR1## wherein R.sub.1 represents a fluoro-substituted lower alkyl group or a cyano-substituted lower alkyl group, and A represents a cyclic or an acylic ammonio group, or a pharmaceutically acceptable salt thereof, exhibiting excellent anti-bacterial activities against both Gram-positive bacteria and Gram-negative bacteria; Process for the preparation thereof; Anti-bacterial composition; Intermediate for the 3-propenylcephem derivative; and Process for the preparation of the intermediate.Type: GrantFiled: January 11, 1990Date of Patent: April 9, 1991Assignee: Eisai, Co.Inventors: Takashi Kamiya, Toshihiko Naito, Shigeto Negi, Yuuki Komatu, Yasunobu Kai, Takaharu Nakamura, Isao Sugiyama, Yoshimasa Machida, Seiichiro Nomoto, Kyosuke Kitoh, Kanemasa Katsu, Hiroshi Yamauchi
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Patent number: 4929612Abstract: Novel thiadiazolylacetamide cephem derivatives of the following formula are described. ##STR1## wherein A represents a quaternary ammonio group; or a pharmaceutically acceptable salt thereof. These novel compounds are useful as antibacterial agents, because they have a broad antibacterial spectrum ranging from gram-negative bacteria to gram-positive bacteria. Processes for the preparation of these novel compounds are also described.Type: GrantFiled: April 14, 1988Date of Patent: May 29, 1990Assignee: Eisai Co., Ltd.Inventors: Yoshimasa Machida, Shigeto Negi, Takashi Kamiya, Yuuki Komatu, Isao Sugiyama, Yasunobu Kai, Takaharu Nakamura, Toshihiko Naito, Kyosuke Kitoh, Kanemasa Katsu, Hiroshi Yamauchi