Patents by Inventor Toshihiko Yoshitake

Toshihiko Yoshitake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neocarzinostatin derivatives and method of producing the same
    Patent number: 4782113
    Abstract: Substantially pure neocarzinostatin anticancer agents have the formula (A):(SMA)--(NCS)--(SMA) (A)wherein (NCS) is a divalent neocarzinostatin residue and (SMA) comprises the monovalent residue of a partially half-esterified styrene-maleic acid copolymer having a weight-average molecular weight of from 800 to 2,500, said (NCS) residue being bonded to said (SMA) residues via amide linkages formed between primary amino groups of the neocarzinostatin molecule and carbonyl groups of the partially half-esterified styrene-maleic acid copolymer.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: November 1, 1988
    Assignees: Kuraray Co., Ltd., Yamanouchi Pharmaceutical Co., Ltd., Kayaku Antibiotics Research Co., Ltd., Hiroshi Maeda
    Inventors: Hiroshi Maeda, Ryunosuke Kanamaru, Nakao Ishida, Toshihiko Yoshitake, Minoru Ueda
  • Neocarzinostatin derivatives and a process for manufacturing the same
    Patent number: 4762885
    Abstract: Substantially pure neocarzinostatin anticancer agents have the formula (A):(SMA)-(NCS)-(SMA) (A)wherein (NCS) is a divalent neocarzinostatin residue and (SMA) comprises the monovalent residue of a styrene-maleic acid copolymer having a weight-average molecular weight of from 800 to 2,500, said (NCS) residue being bonded to said (SMA) residues via amide linkages formed between primary amino groups of the neocarzinostatin molecule and carbonyl groups of the styrene-maleic acid copolymer.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: August 9, 1988
    Assignees: Kuraray Co., Ltd., Yamanouchi Pharmaceutical Co., Ltd., Kayaku Antibiotics Research Co., Ltd., Hiroshi Maeda
    Inventors: Hiroshi Maeda, Ryunosuke Kanamaru, Nakao Ishida, Toshihiko Yoshitake, Minoru Ueda
  • Neocarzinostatin complexes, a method for producing the same, and an antitumor agent containing said complexes as an active component
    Patent number: 4732933
    Abstract: Novel neocarzinostatin anticancer agents have the formula:(SMA)--(NCS)wherein (NCS) is a neocarzinostatin residue, n is an integer ranging from 1 to 35, and (SMA) comprises the residue of a half-esterified styrene-maleic acid copolymer having an average molecular weight of from 1,000 to 10,000, said half-esterified styrene-maleic acid copolymer comprising (i) styrene residues, (ii) maleic acid residues covalently bonded to (NCS), (iii) free maleic acid residues, and (iv) half-esterified maleic acid residues, and further wherein the total amount of said residues (ii) and (iii) ranges from an average of 0.1 per molecule to 60 mole % of said (SMA).
    Type: Grant
    Filed: May 6, 1985
    Date of Patent: March 22, 1988
    Assignees: Kayaku Antibiotics Research Co., Ltd., Kuraray Co., Ltd., Yamanouchi Pharmaceutical Co., Ltd., Hiroshi Maeda
    Inventors: Hiroshi Maeda, Ryunosuke Kanamaru, Nakao Ishida, Toshihiko Yoshitake, Minoru Ueda
  • Absorbents with improved water absorbing power
    Patent number: 4251643
    Abstract: Absorbent materials for aqueous fluids, which absorb fluid rapidly and swell uniformly, comprise modified polyvinyl alcohol polymers obtained by reacting in an anhydrous condition a polyvinyl alcohol polymer with a cyclic acid anhydride and causing partial crosslinking of said polymer. Absorbent articles such as diapers, sanitary napkins, sanitary tampons, blood absorbents for use in surgical operations, bandages and dressings comprise said absorbent materials and fluid absorbing holders therefor.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: February 17, 1981
    Assignee: Kuraray Co., Ltd.
    Inventors: Kazuto Harada, Toshihiko Yoshitake