Patents by Inventor Toshikazu Yoshikawa

Toshikazu Yoshikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11459546
    Abstract: The present invention addresses the problem of providing: a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells from somatic cells without performing artificial gene transfer; brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells; or a composition including a combination of chemical substances that can be used for the aforementioned production method. An example of the present invention is a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells including a step for culturing somatic cells in the presence or absence of an inhibitor or activator selected from the group consisting of an ALK5 inhibitor, an ALK6 inhibitor, an AMPK inhibitor, a cAMP activator, an ALK2 inhibitor, an ALK3 inhibitor, a GSK3 inhibitor, and an Erk inhibitor.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: October 4, 2022
    Assignees: Kyoto Prefectural Public University Corporation, Kataoka Corporation
    Inventors: Yuta Murakami, Yasuhiro Yoshioka, Ping Dai, Toshikazu Yoshikawa, Yoshinori Harada
  • Patent number: 10767535
    Abstract: There is provided a method for recycling a catalyst that exhibits a high denitration efficiency at a relatively low temperature and does not cause oxidation of SO2 in a selective catalytic reduction reaction that uses ammonia as a reducing agent. A method for recycling a denitration catalyst includes a step of spraying an aqueous solution with a pH of 7 or more onto a used denitration catalyst while the denitration catalyst is set in a denitration device to remove a surface of the denitration catalyst. The denitration catalyst contains 43 wt % or more of vanadium pentoxide and has a BET specific surface area of 30 m2/g or more. The denitration catalyst after recycling is used for denitration at 200° C. or lower.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: September 8, 2020
    Assignees: THE CHUGOKU ELECTRIC POWER CO., INC., TOKYO METROPOLITAN UNIVERSITY
    Inventors: Eiji Kiyonaga, Kenji Hikino, Keiichiro Morita, Toshikazu Yoshikawa, Masatake Haruta, Toru Murayama, Makoto Mino
  • Patent number: 10746074
    Abstract: There is provided a method for recycling a catalyst that exhibits a high denitration efficiency at a relatively low temperature and does not cause oxidation of SO2 in a selective catalytic reduction reaction that uses ammonia as a reducing agent. A method for recycling a denitration catalyst includes a step of removing a used denitration catalyst from a denitration device and then coating the used denitration catalyst with a catalyst component. The catalyst component contains 43 wt % or more of vanadium pentoxide and has a BET specific surface area of 30 m2/g or more, and the denitration catalyst after recycling is used for denitration at 200° C. or lower.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: August 18, 2020
    Assignees: THE CHUGOKU ELECTRIC POWER CO., INC., TOKYO METROPOLITAN UNIVERSITY
    Inventors: Eiji Kiyonaga, Kenji Hikino, Keiichiro Morita, Toshikazu Yoshikawa, Masatake Haruta, Toru Murayama, Makoto Mino
  • Publication number: 20190218516
    Abstract: The present invention addresses the problem of providing: a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells from somatic cells without performing artificial gene transfer; brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells; or a composition including a combination of chemical substances that can be used for the aforementioned production method. An example of the present invention is a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells including a step for culturing somatic cells in the presence or absence of an inhibitor or activator selected from the group consisting of an ALK5 inhibitor, an ALK6 inhibitor, an AMPK inhibitor, a cAMP activator, an ALK2 inhibitor, an ALK3 inhibitor, a GSK3 inhibitor, and an Erk inhibitor.
    Type: Application
    Filed: September 27, 2017
    Publication date: July 18, 2019
    Applicant: Kyoto Prefectural Public University Corporation
    Inventors: Yuta MURAKAMI, Yasuhiro YOSHIOKA, Ping DAI, Toshikazu YOSHIKAWA, Yoshinori HARADA
  • Patent number: 10335780
    Abstract: A method for regenerating an NOx removal catalyst, which includes connecting an upstream fixing member (10) to one end of a member to be ground, and connecting a downstream fixing member (20) to the other end; connecting a mixing part (40) for mixing an abrasive with a gas to an upstream portion of the upstream fixing member, and disposing a screen member in the expanded part, and connecting a classification part (70) and a dust-collecting part (80) to the downstream fixing member; and transferring the abrasive which has been mixed with the gas from the mixing part to the upstream fixing member, reducing the flow rate of the mixture in the expanded part, subsequently, causing the mixture to pass through the through-hole of the NOx removal catalyst and the downstream fixing member, and then collecting dust by means of the dust-collecting part via the classification part.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: July 2, 2019
    Assignee: THE CHUGOKU ELECTRIC POWER CO., INC.
    Inventors: Toshikazu Yoshikawa, Kazuhiro Yoshida, Hiroshi Shimada, Misao Nobori, Atsushi Ito, Fumihiro Miyake, Yuichiro Morizane, Hiroyuki Kagawa
  • Publication number: 20180280936
    Abstract: There is provided a catalyst that exhibits a high denitration efficiency at a relatively low temperature and does not cause oxidation of SO2 in a selective catalytic reduction reaction that uses ammonia as a reducing agent. A denitration catalyst molded in a block shape contains 43 wt % or more of vanadium pentoxide. The denitration catalyst has a BET specific surface area of 30 m2/g or more and is used for denitration at 200° C. or lower.
    Type: Application
    Filed: March 7, 2017
    Publication date: October 4, 2018
    Inventors: Eiji KIYONAGA, Kenji HIKINO, Keiichiro MORITA, Toshikazu YOSHIKAWA, Masatake HARUTA, Toru MURAYAMA, Makoto MINO
  • Publication number: 20180280941
    Abstract: There is provided a method for recycling a catalyst that exhibits a high denitration efficiency at a relatively low temperature and does not cause oxidation of SO2 in a selective catalytic reduction reaction that uses ammonia as a reducing agent. A method for recycling a denitration catalyst includes a step of removing a used denitration catalyst from a denitration device and then coating the used denitration catalyst with a catalyst component. The catalyst component contains 43 wt % or more of vanadium pentoxide and has a BET specific surface area of 30 m2/g or more, and the denitration catalyst after recycling is used for denitration at 200° C. or lower.
    Type: Application
    Filed: March 7, 2017
    Publication date: October 4, 2018
    Inventors: Eiji KIYONAGA, Kenji HIKINO, Keiichiro MORITA, Toshikazu YOSHIKAWA, Masatake HARUTA, Toru MURAYAMA, Makoto MINO
  • Publication number: 20180280965
    Abstract: There is provided a method for recycling a catalyst that exhibits a high denitration efficiency at a relatively low temperature and does not cause oxidation of SO2 in a selective catalytic reduction reaction that uses ammonia as a reducing agent. A method for recycling a denitration catalyst includes a step of spraying an aqueous solution with a pH of 7 or more onto a used denitration catalyst while the denitration catalyst is set in a denitration device to remove a surface of the denitration catalyst. The denitration catalyst contains 43 wt % or more of vanadium pentoxide and has a BET specific surface area of 30 m2/g or more. The denitration catalyst after recycling is used for denitration at 200° C. or lower.
    Type: Application
    Filed: March 7, 2017
    Publication date: October 4, 2018
    Inventors: Eiji KIYONAGA, Kenji HIKINO, Keiichiro MORITA, Toshikazu YOSHIKAWA, Masatake HARUTA, Toru MURAYAMA, Makoto MINO
  • Publication number: 20160051976
    Abstract: A method for regenerating an NOx removal catalyst, which includes connecting an upstream fixing member (10) to one end of a member to be ground, and connecting a downstream fixing member (20) to the other end; connecting a mixing part (40) for mixing an abrasive with a gas to an upstream portion of the upstream fixing member, and disposing a screen member in the expanded part, and connecting a classification part (70) and a dust-collecting part (80) to the downstream fixing member; and transferring the abrasive which has been mixed with the gas from the mixing part to the upstream fixing member, reducing the flow rate of the mixture in the expanded part, subsequently, causing the mixture to pass through the through-hole of the NOx removal catalyst and the downstream fixing member, and then collecting dust by means of the dust-collecting part via the classification part.
    Type: Application
    Filed: March 28, 2013
    Publication date: February 25, 2016
    Applicant: THE CHUGOKU ELECTRIC POWER CO., INC.
    Inventors: Toshikazu YOSHIKAWA, Kazuhiro YOSHIDA, Hiroshi SHIMADA, Misao NOBORI, Atsushi ITO, Fumihiro MIYAKE, Yuichiro MORIZANE, Hiroyuki KAGAWA
  • Publication number: 20150307549
    Abstract: Provided is an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
    Type: Application
    Filed: July 8, 2015
    Publication date: October 29, 2015
    Applicant: CALPIS Co., LTD
    Inventors: Tatsuhiko HIROTA, Teppei NAKAMURA, Kohji OHKI, Akihiro MASUYAMA, Toshiaki TAKANO, Toshikazu YOSHIKAWA, Yuji NAITO, Hiroshi ICHIKAWA, Satomi AKAGIRI
  • Publication number: 20120035096
    Abstract: There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
    Type: Application
    Filed: October 21, 2011
    Publication date: February 9, 2012
    Applicant: CALPIS CO., LTD.
    Inventors: Tatsuhiko HIROTA, Teppei NAKAMURA, Kohji OHKI, Akihiro MASUYAMA, Toshiaki TANAKO, Toshikazu YOSHIKAWA, Yuji NAITO, Hiroshi ICHIKAWA, Satomi AKAGIRI
  • Publication number: 20090299036
    Abstract: There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
    Type: Application
    Filed: February 14, 2007
    Publication date: December 3, 2009
    Applicant: Calpis Co, Ltd
    Inventors: Tatsuhiko Hirota, Teppei Nakamura, Kohji Ohki, Akihiro Masuyama, Toshiaki Takano, Toshikazu Yoshikawa, Yuji Naito, Hiroshi Ichikawa, Satomi Akagiri
  • Publication number: 20040196444
    Abstract: A method that adjusts an optical apparatus that guides a radiation from a first surface to a second surface includes a number of steps, for example. A first step measures an aberration of the optical apparatus having a plurality of optical elements and at least one correction element. A second step calculates, based on a measurement result of the first step, a surface shape that the correction element should have, the aberration of the optical apparatus being a predetermined value when the correction element has the surface shape that the correction element should have. A third step removes the correction element from the optical apparatus and machines the correction element so that the surface shape of the correction element coincides with the surface shape calculated in the second step. A fourth step returns the correction element machined in the third step into the optical apparatus.
    Type: Application
    Filed: April 22, 2004
    Publication date: October 7, 2004
    Applicant: NIKON CORPORATION
    Inventors: Hiroshi Chiba, Toshikazu Yoshikawa
  • Publication number: 20040191913
    Abstract: Provided is a method of evaluation of antioxidation level through determination of in-vivo redox balance. The redox balance is represented by a formula: redox balance=(antioxidation index after administration/oxidation index after administration)/(antioxidation index before administration/oxidation index before administration). The antioxidation index is obtained by indexing the antioxidation level that is obtained through quantitative determination of the signal intensity attenuation with serum addition thereto of the DMPO-OOL radical formed through trapping of a butylhydroperoxide radical by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) by the use of a magnetic spin resonator followed by analysis of the data for 10-grade frequency distribution of from 1 to 10, and the oxidation index is obtained by indexing the oxidation level that is obtained through quantitative determination of 8-hydroxydeoxyguanosine (8-OHdG) in urine followed by analysis of the data for 10-grade frequency distribution of from 1 to 10.
    Type: Application
    Filed: December 31, 2003
    Publication date: September 30, 2004
    Inventor: Toshikazu Yoshikawa
  • Publication number: 20030174297
    Abstract: This invention relates to an adjusting method for correcting the random component of distortion of a projection optical apparatus without performing complicated assembly and adjustment. This adjusting method has the first step of measuring the residual distortion component of a projection optical system having a predetermined target member in its optical path, the second step of calculating, based on the measurement result of the first step, the surface shape of the target member to cancel the residual distortion component, the third step of removing the target member from the projection optical system and machining the target member so as to have the surface shape calculated in the second step, and the fourth step of inserting the target member machined in the third step into the optical path of the projection optical system.
    Type: Application
    Filed: January 17, 2003
    Publication date: September 18, 2003
    Applicant: Nikon Corporation
    Inventors: Hiroshi Chiba, Toshikazu Yoshikawa
  • Patent number: 6518250
    Abstract: An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: [wherein R1, R2, R3, and R4 independently denote a hydrogen atom or a lower alkyl group, R5 denotes a hydrogen atom, a lower alkyl group, or a lower acyl group, X denotes a monosaccharide residue or an oligosaccharide residue which may have a lower alkyl group or a lower acyl group substituted for the hydrogen atom of the hydroxyl group of the saccharide residue, n denotes an integer of 0-6, and m denotes an integer of 1-6]. The agent, even in a small dosage, acts safely and effectively on the affected part and allows the hindrances of ischemic reperfusion induced in heart, stomach, small intestine, liver, spleen, kidney, brain, and skin, and the hindrance induced during the transplantation of an internal organ to be prevented and cured.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: February 11, 2003
    Assignee: CCI Corporation
    Inventors: Toshikazu Yoshikawa, Hironobu Murase, Norimasa Yoshida
  • Publication number: 20020128211
    Abstract: An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: 1
    Type: Application
    Filed: November 14, 2001
    Publication date: September 12, 2002
    Inventors: Toshikazu Yoshikawa, Hironobu Murase, Norimasa Yoshida
  • Publication number: 20020054214
    Abstract: A signal prediction device and camera including a signal prediction device are provided in which the signal prediction device includes a signal detection part for detecting a signal series, a prediction coefficient calculation part for calculating prediction coefficients using the detected signal series, and a prediction calculation part for performing operations on the prediction coefficients and an updated signal series to predict future signals, wherein the updated signal series includes at least one future signal value for which a prediction operation has been previously performed from a signal series detected by the signal detection part and the prediction coefficients as the current signals.
    Type: Application
    Filed: September 21, 2001
    Publication date: May 9, 2002
    Applicant: NIKON CORPORATION
    Inventor: Toshikazu Yoshikawa
  • Patent number: 6377333
    Abstract: This invention relates to an adjusting method for correcting the random component of distortion of a projection optical apparatus without performing complicated assembly and adjustment. This adjusting method has the first step of measuring the residual distortion component of a projection optical system having a predetermined target member in its optical path, the second step of calculating, based on the measurement result of the first step, the surface shape of the target member to cancel the residual distortion component, the third step of removing the target member from the projection optical system and machining the target member so as to have the surface shape calculated in the second step, and the fourth step of inserting the target member machined in the third step into the optical path of the projection optical system.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 23, 2002
    Assignee: Nikon Corporation
    Inventors: Hiroshi Chiba, Toshikazu Yoshikawa
  • Patent number: 6268903
    Abstract: A method adjusts optical performance of a projection optical system for projecting an image of a first object onto a second object. An optical member is provided having a predetermined optical surface, at a predetermined position of the projection optical system. Measurement is made of an aberration having a random aberration component in the projection optical system including the optical member at the predetermined position. A correction shape is obtained to correct the random aberration component. The correction shape is then formed on a correction optical member, and that correction optical member is arranged at the predetermined position of the projection optical system.
    Type: Grant
    Filed: January 3, 1996
    Date of Patent: July 31, 2001
    Assignee: Nikon Corporation
    Inventors: Hiroshi Chiba, Toshikazu Yoshikawa