Patents by Inventor Toshio Miyake

Toshio Miyake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7951530
    Abstract: An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above object by providing a novel cyclic saccharide having a structure of cyclo{>6)-?-D-glucopyranosyl-(1>4)-?-D-glucopyranosyl-(1>6)-?-D-glucopyranosyl-(1>4)-?-D-glucopyranosyl-(1>}, cyclic maltosylmaltose, novel cyclic maltosylmaltose-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the cyclic maltosylmaltose or a saccharide composition comprising the same, and uses thereof.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: May 31, 2011
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kazuhisa Mukai, Hikaru Watanabe, Tomoyuki Nishimoto, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20110091726
    Abstract: The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25° C.
    Type: Application
    Filed: September 3, 2010
    Publication date: April 21, 2011
    Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takashi Shibuya, Seisuke Izawa, Tomoyuki Nishimoto, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20110045137
    Abstract: The objects of the present invention are to provide a method for inhibiting the coloration of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a ?-fructofuranosidic linkage, without deteriorating the taste inherent to the syrupy sweetener; and to provide a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a ?-fructofuranosidic linkage, which is stabilized by the method. The present invention attains the above objects by providing a method for inhibiting the coloring of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a ?-fructofuranosidic linkage, which comprises a step of incorporating a lactate into the syrupy sweetener, and by providing a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a ?-fructofuranosidic linkage, which is stabilized by the method.
    Type: Application
    Filed: April 27, 2009
    Publication date: February 24, 2011
    Inventors: Kenshi Yoshida, Ikuo Sawatani, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7854922
    Abstract: The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and/or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of ?,?-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: December 21, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Fujimi Tanabe, Michio Kubota, Hiromi Tatsukawa, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20100285562
    Abstract: A non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents, a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof are provided by use of an isocyclomaltooligosaccharide(s) having a structure represented by Formula 1, Cyclo{?6)-[?-D-Glcp-(1?4)]n-?-D-Glcp-(1?}, wherein “n” is 4 or 5.
    Type: Application
    Filed: April 21, 2010
    Publication date: November 11, 2010
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Hikaru Watanabe, Tomoyuki Nishimoto, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7811797
    Abstract: The object of the present invention is to provide an ?-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an ?-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the ?-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the ?-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; ?-isomaltosyl-transferring method using the enzyme; method for forming ?-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-?-D-glucopyranosyl-(163)-?-D-glucopyranosyl-
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: October 12, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Michio Kubota, Keiji Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20100252987
    Abstract: A feeder unit includes: a first tray that keeps a storage position in which the first tray is stored within the base portion and an operation position, and is provided at one end of a feeding path of a medium so as to place the medium thereon; a cover member that is openably and closeably provided to cover the first tray in the storage position when being closed or uncover the first tray when being open; and a first power transmitter that transmits power to open and close the cover member to the first tray, and the first power transmitter is configured so as to displace the first tray to the operation position with the displacement of the cover member when the cover member is switched to an open-state, and to the storage position with the displacement of the cover member when the cover member is switched to a closed-state.
    Type: Application
    Filed: March 31, 2010
    Publication date: October 7, 2010
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Masafumi FURUYAMA, Toshio MIYAKE
  • Patent number: 7799765
    Abstract: The object of the present invention is to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in water, etc., are improved; and their preparation and uses. The present invention solves the above object by providing an associate of trehalose or maltitol and a metal ion compound or bittern component, and their preparation and uses.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: September 21, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20100222569
    Abstract: An object of the present invention is to provide a crystalline saccharide having novel physical properties, a preparation and uses thereof. The present invention solves the above objects by providing a porous crystalline saccharide having a number of pores, a process for producing the same, comprising the step of keeping hydrous crystalline saccharide at an ambient temperature or higher in an organic solvent for the dehydration, and the use thereof.
    Type: Application
    Filed: December 25, 2006
    Publication date: September 2, 2010
    Inventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
  • Publication number: 20100210589
    Abstract: An object of the present invention is to provide a means for improving hepatic function of mammals including humans to normal condition. The present invention achieves the above object by providing a hepatic function-improving agent comprising ?-glucosyl-hesperidin as an effective ingredient.
    Type: Application
    Filed: April 27, 2010
    Publication date: August 19, 2010
    Applicant: Kabushiki Kaisha Kayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hitoshi MITSUZUMI, Mika TAKAMI, Yoshikatsu MIWA, Hiroto CHAEN, Toshio MIYAKE
  • Patent number: 7749538
    Abstract: Since conventional high pullulan content shaped products have a low stability to the change of humidity, the object of the present invention is to provide a high pullulan content shaped product having a satisfactory stability to the change of humidity, a process for producing the same, and uses. The present invention solves the above object by establishing high pullulan content shaped product with an improved stability to the change of humidity by incorporating a prescribed amount of ?,?-trehalose into pullulan in preparing the high pullulan content shaped product, and a process for producing the same, and by providing uses of the high pullulan content shaped product obtainable by the process.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: July 6, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Toshiyuki Sugimoto, Toshio Miyake
  • Patent number: 7732426
    Abstract: The present invention have objects to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above objects by providing an isocyclomaltooligosaccharide(s) having a structure represented by General Formula 1, a novel isocyclomaltooligosaccharide-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the isocyclomaltooligosaccharide(s) or a saccharide composition comprising the same, and uses thereof. Cyclo{?6)-[?-D-Glcp-(1?4)]n-?-D-Glcp-(1?}??General Formula 1 (In General Formula 1, “n” means a number of 4 or 5).
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: June 8, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hikaru Watanabe, Tomoyuki Nishimoto, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7731178
    Abstract: A feeding device includes: a hopper, adapted to support a medium; a feeder, operable to feed the medium in a first direction; a separator, operable to nip the medium with the feeder at a nip point; and a guide, having a guide surface which guides the medium in the first direction and is provided with a recessed portion at a downstream side of the nip point in the first direction.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: June 8, 2010
    Assignee: Seiko Epson Corporation
    Inventors: Toshio Miyake, Atsuhiko Takeuchi, Yuji Miyamoto
  • Patent number: 7718404
    Abstract: The object of the present invention is to provide an ?-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an ?-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the ?-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the ?-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; ?-isomaltosyl-transferring method using the enzyme; method for forming ?-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-?-D-glucopyranosyl-(163)-?-D-glucopyranosyl-
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: May 18, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Michio Kubota, Keiji Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7709230
    Abstract: A novel process for producing isomaltose and uses thereof and comprising the steps of contacting saccharides, which have a glucose polymerization degree of at least two and ?-1,4 glucosidic linkage as a linkage at the non-reducing end, with an ?-isomaltosylglucosaccharide-forming enzyme, in the presence or the absence of ?-isomaltosyl-transferring enzyme to form a-isomaltosylglucosaccharides, which have a glucose polymerization degree of at least three, ?-1,6 glucosidic linkage as a linkage at the non-reducing end, and ?-1,4 glucosidic linkage as a linkage other than the non-reducing end, and/or to form cyclo{?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?}; contacting the saccharides so formed with isomaltose-releasing enzyme to release isomaltose; and collecting the released isomaltose; and uses thereof.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: May 4, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Michio Kubota, Tomoyuki Nishimoto, Takanobu Higashiyama, Hikaru Watanabe, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20100062139
    Abstract: An object of the present invention is to provide a dried vegetable comprising saccharide, which shows preferable rehydrating property and good shape, color, and relish when rehydrating it and can be used as a material of instant foods and side dishes, a process for producing the dried vegetable, and uses thereof. The above object is attained by providing a dried vegetable comprising saccharide, which is obtained by permeating a saccharide(s) into a vegetable and drying with hot air, and said dried vegetable comprising saccharide shows following physical properties of (1) and (2): (1) The dry weight of residue which is obtained by extracting said dried vegetable comprising saccharide with 60% ethanol aqueous solution accounts for 15% or higher but lower than 35% to the weight of said dried vegetable comprising saccharide; and (2) The specific gravity of said dried vegetable comprising saccharide is increased by 0.
    Type: Application
    Filed: November 20, 2007
    Publication date: March 11, 2010
    Inventors: Naohiko Katagiri, Noriyuki Saito, Takanao Sogawa, Toshio Miyake
  • Publication number: 20100015671
    Abstract: An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above object by providing a novel cyclic saccharide having a structure of cyclo{>6)-?-D-glucopyranosyl-(1>4)-?-D-glucopyranosyl-(1>6)-?-D-glucopyranosyl-(1>4)-?-D-glucopyranosyl-(1>}, cyclic maltosylmaltose, novel cyclic maltosylmaltose-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the cyclic maltosylmaltose or a saccharide composition comprising the same, and uses thereof.
    Type: Application
    Filed: November 16, 2007
    Publication date: January 21, 2010
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Kazuhisa Mukai, Hikaru Watanabe, Tomoyuki Nishimoto, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20090292116
    Abstract: Objects of the present invention are to provide a novel anhydrous crystalline ?-maltose, its preparation and uses. The present invention attains the above objects by providing an anhydrous crystalline ?-maltose with a melting point of 154 to 159° C.; a process for producing the same, comprising a step of keeping hydrous crystalline ?-maltose in an organic solvent at an ambient temperature or higher for the dehydration; and uses of the same.
    Type: Application
    Filed: July 5, 2007
    Publication date: November 26, 2009
    Inventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
  • Patent number: 7592160
    Abstract: The present invention aims to provide a novel process for producing isomaltose and isomaltitol, and uses thereof, and it solves the object by establishing a process for producing isomaltose comprising a step of contacting a saccharide, having the ?-1,4 glucosidic linkage as the linkage of non-reducing end and a glucose polymerization degree of at least two, with an ?-isomaltosyl-transferring enzyme and an ?-isomaltosylglucosaccharide-forming enzyme derived from a specific microorganism; a process for producing isomaltitol using the isomaltose produced by the above process; saccharide compositions comprising the isomaltose and/or the isomaltitol produced by the above processes; and uses thereof.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: September 22, 2009
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Michio Kubota, Tomoyuki Nishimoto, Tomohiko Sonoda, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7582463
    Abstract: A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60° C.; and an optimum pH in an acid pH range, i.e., a pH of less than 7. The two-types of enzymes can be obtained in a desired amount, for example, by culturing in a nutrient culture medium microorganisms capable of producing the enzymes or by recombinant DNA technology.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: September 1, 2009
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takuo Yamamoto, Kazuhiko Maruta, Michio Kubota, Shigeharu Fukuda, Toshio Miyake