Patents by Inventor Toshio Miyawaki
Toshio Miyawaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9108986Abstract: Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process.Type: GrantFiled: July 13, 2012Date of Patent: August 18, 2015Assignee: HAMARI CHEMICALS, LTD.Inventors: Sadayuki Maeda, Tatsunori Sato, Yasuhiko Kawano, Toshio Miyawaki
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Publication number: 20140228572Abstract: Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process.Type: ApplicationFiled: July 13, 2012Publication date: August 14, 2014Applicant: HAMARI CHEMICALS, LTD.Inventors: Sadayuki Maeda, Tatsunori Sato, Yasuhiko Kawano, Toshio Miyawaki
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Patent number: 7649001Abstract: The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3? (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3? represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5? (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5? represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively.Type: GrantFiled: August 11, 2003Date of Patent: January 19, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsuru Shiraishi, Takahito Hara, Masami Kusaka, Naoyuki Kanzaki, Satoshi Yamamoto, Toshio Miyawaki
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Publication number: 20060106067Abstract: The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3? (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3? represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5? (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5? represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively.Type: ApplicationFiled: August 11, 2003Publication date: May 18, 2006Inventors: Mitsuru Shiraishi, Takahito Hara, Masami Kusaka, Naoyuki Kanzaki, Satoshi Yamamoto, Toshio Miyawaki
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Publication number: 20050227223Abstract: A method for diagnosing a viral infection without complicating bacterial infection, which comprises determining a C-reactive protein and an MxA protein in a biological sample; a kit for judging viral infection without complicating bacterial infection, which comprises a reagent for determining a C-reactive protein and a reagent for determining an MxA protein in a biological sample.Type: ApplicationFiled: March 20, 2003Publication date: October 13, 2005Inventor: Toshio Miyawaki
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Publication number: 20030187023Abstract: A compound represented by the formula: 1Type: ApplicationFiled: January 16, 2003Publication date: October 2, 2003Inventors: Keiji Kubo, Toshio Miyawaki, Masaki Kawamura
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Patent number: 6020334Abstract: The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell-adhesion. Especially, the compounds of this invention perform platelet aggregation action without remarkable elongation of hemorrhagic period and can be used as a safe and long-acting antithrombotic drug as compared with known substances showing the same activity.Type: GrantFiled: September 1, 1998Date of Patent: February 1, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Hideto Fukushi, Takehiko Naka, Zen-ichi Terashita, Toshio Miyawaki
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Patent number: 5935963Abstract: The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell-adhesion. Especially, the compounds of this invention perform platelet aggregation action without remarkable elongation of hemorrhagic period and can be used as a safe and long-acting antithrombotic drug as compared with known substances showing the same activity.Type: GrantFiled: July 10, 1996Date of Patent: August 10, 1999Assignee: Takeda Chemical Industries, LtdInventors: Hideto Fukushi, Takehiko Naka, Zen-ichi Terashita, Toshio Miyawaki
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Patent number: 5344928Abstract: There is disclosed a novel phenothiazine derivative of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are a C.sub.1-6 alkyl group and at least one of them has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X.sup.- is a counter ion of the phenazathionium. Their production and the intermediates used in the production are also disclosed. The compound (I) is a derivative of methylene blue and is applicable to photodynamic therapy of cancer or immunoassays utilizing chemiluminescence.Type: GrantFiled: April 14, 1992Date of Patent: September 6, 1994Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirotomo Masuya, Hiroshi Shimadzu, Toshio Miyawaki, Marvin A. Motsenbocker
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Patent number: 4517361Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula -SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: March 31, 1983Date of Patent: May 14, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Minamida, Masayoshi Yamaoka, Mitsuru Shiraishi, Toshio Miyawaki
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Patent number: 4421912Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula --NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula --SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: February 18, 1981Date of Patent: December 20, 1983Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Mimamida, Masayoshi Yamaoka, Mitsuru Shiraishi, Toshio Miyawaki
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Patent number: 4379924Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula --NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula --SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: December 23, 1977Date of Patent: April 12, 1983Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Mimamida, Masayoshi Yamaoka, Mitsura Shiraishi, Toshio Miyawaki
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Patent number: 4251657Abstract: A halogenoacetyl group is removed from a halogenoacetyl amino compound in a short period of reaction time by reacting the halogenoacetyl amino compound with an N-substituted dithiocarbamic acid or a salt thereof.Type: GrantFiled: December 5, 1978Date of Patent: February 17, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Michihiko Ochiai, Akira Morimoto, Toshio Miyawaki
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Patent number: 4080498Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula --NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula --SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: December 20, 1974Date of Patent: March 21, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Minamida, Masayoshi Yamaoka, Mitsuru Shiraishi, Toshio Miyawaki
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Patent number: 4011214Abstract: Novel cephalosporin compounds of the formula ##STR1## wherein R.sup.1 is an acyl group and R.sup.2 is an alkylene group which may be substituted with a lower alkoxyl group, or pharmaceutically acceptable salt thereof, have strong inhibitory actions on broad spectra of gram-positive and gram-negative bacteria and, particularly against Esherichia coli and Klebsiella pneumoniae. Thus, the compounds are useful as therapeutic agent for various bacterial infections of animals including human beings.Type: GrantFiled: December 20, 1974Date of Patent: March 8, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Mitsuru Shiraishi, Toshio Miyawaki, Isao Minamida, Masayoshi Yamaoka, Mitsuo Numata
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Patent number: 3984401Abstract: A 3-hydroxymethylcephalosporin which is not protected at the carboxyl group can be directly oxidized with a hexavalent chromium compound to give in good yield a lactol type cephalosporin represented by the general formula: ##SPC1##Wherein R.sup.1 is hydrogen or an alkoxy group and R.sup.2 is an acylamino, or imido group. The resulting compounds are very useful and important as intermediates for preparing, e.g. 3-alkoxyiminomethyl cephalosporins.Type: GrantFiled: December 7, 1973Date of Patent: October 5, 1976Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Mitsuru Shiraishi, Toshio Miyawaki, Isao Minamida, Masayoshi Yamaoka, Yoshio Imashiro, Mitsuo Numata