Abstract: Disclosed are quinolone derivatives characterized in that these have lower alkyl, cycloalkyl or the like at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof, has excellent P2Y12 inhibitory activity. The quinolone derivatives have excellent platelet aggregation inhibitory activity. A method of using the compounds is also disclosed.

Abstract: Disclosed are quinolone derivatives characterized in that these have lower alkyl, cycloalkyl or the like at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof, has excellent P2Y12 inhibitory activity. The quinolone derivatives have excellent platelet aggregation inhibitory activity. A method of using the compounds is also disclosed.

Abstract: Provided are quinolone derivatives having a lower alkyl or cycloalkyl at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof. Pharmaceutical composition containing the quinolone derivatives and methods of using the compositions are provided.

Abstract: [Problem] To provide a compound having excellent platelet aggregation inhibitory activity. [Means for Resolution] It was found that quinolone derivatives characterized in that these have lower alkyl, cycloalkyl or the like at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof, has excellent P2Y12 inhibitory activity. In addition, it was confirmed that these quinolone derivatives also have excellent platelet aggregation inhibitory activity. Based on the above, these quinolone derivatives or pharmaceutically acceptable salts thereof are useful as platelet aggregation inhibitors.

Abstract: A method for the prevention and/or treatment of peripheral arterial disease by compound (I) or its pharmaceutically salts are provided. The compound (I) or its pharmaceutically salts have inhibitory activity against heterotrimeric G protein Gq/11.

Abstract: A first silicon film is so formed as to extend along the inner surface of trenches 52 formed in a silicon oxide film 50, an oxide film is formed on the surface of the first silicon film, and a second amorphous silicon film is further deposited. Heat-treatment is applied to the surface of the second amorphous silicon film for seeding silicon nuclei and for promoting grain growth, and a granular silicon crystal 57 is grown from the second amorphous silicon film. In this way, the resistance of a lower electrode 59 of a capacitance device can be lowered.

Abstract: A first silicon film is so formed as to extend along the inner surface of trenches 52 formed in a silicon oxide film 50, an oxide film is formed on the surface of the first silicon film, and a second amorphous silicon film is further deposited. Heat-treatment is applied to the surface of the second amorphous silicon film for seeding silicon nuclei and for promoting grain growth, and a granular silicon crystal 57 is grown from the second amorphous silicon film. In this way, the resistance of a lower electrode 59 of a capacitance device can be lowered.

Abstract: A first silicon film is so formed as to extend along the inner surface of trenches 52 formed in a silicon oxide film 50, an oxide film is formed on the surface of the first silicon film, and a second amorphous silicon film is further deposited. Heat-treatment is applied to the surface of the second amorphous silicon film for seeding silicon nuclei and for promoting grain growth, and a granular silicon crystal 57 is grown from the second amorphous silicon film. In this way, the resistance of a lower electrode 59 of a capacitance device can be lowered.

Abstract: A coal combustion apparatus capable of improving NO.sub.x reduction to a large extent is provided, which apparatus comprises a pulverized coal-feeding pipe (abbreviated to coal pipe) inserted into a burner throat on the lateral wall of a combustion furnace and for feeding the coal and air into the furnace; a means for feeding the coal and air into the coal pipe; a secondary air passageway formed between the coal pipe and a secondary air-feeding pipe provided on the outer peripheral side of the coal pipe; a ternary air passageway formed on the outer peripheral side of the secondary air-feeding pipe; a means for feeding air or an oxygen-containing gas into the secondary air passageway and that into the ternary air passageway; and a bluff body having a cross-section of a L-letter form provided at the tip end of the coal pipe.

Abstract: An incinerator for burning waste including a hollow body having an opened upper end and an opened lower end, a bottom plate closing the lower end, a central opening provided in the bottom plate for introducing pressurized oxidizing gas into the hollow body, a plurality of circumferentially disposed openings provided in the bottom plate for introducing pressurized oxidizing gas into the hollow body, an oxidizing gas feeding means for supplying gas to the central opening and the circumferentially disposed openings, heat transfer medium particles provided in the hollow body and fluidized by the oxidizing gas introduced into the hollow body and a means for feeding waste into the hollow body.

Abstract: This invention relates to an apparatus of regenerating fluidizing medium employed in a fluidized-bed incinerator, wherein the sticking matter attached to the fluidizing medium employed in the incinerator in the process of burning up in the incinerator the ash collected from power plant boiler exhaust gases (EP ash) is removed from the fluidizing medium chemically and physically.

Abstract: An incinerator for burning waste including a hollow body having an opened upper end and an opened lower end, a bottom plate closing the lower end, a central opening provided in the bottom plate for introducing pressurized oxidizing gas into the hollow body, a plurality of circumferentially disposed openings provided in the bottom plate for introducing pressurized oxidizing gas into the hollow body, an oxidizing gas feeding means for supplying gas to the central opening and the circumferentially disposed openings, heat transfer medium particles provided in the hollow body and fluidized by the oxidizing gas introduced into the hollow body and a means for feeding waste into the hollow body.