Abstract: A pneumatic tire with improved heat build-up resistance in a land portion in a tread center region.

Abstract: The present technology provides a heavy duty pneumatic tire with a tread portion having a tread pattern including: a pair of circumferential primary grooves defined in a wave-like shape and extending in the tire circumferential direction; center lug grooves; center blocks; and circumferential secondary grooves extending in regions of the center blocks and open to the center lug grooves. The center lug grooves have two groove turning portions turned in a bend shape or a curved shape. The circumferential secondary grooves extend in an inclined manner relative to the tire circumferential direction. An inclination angle (?4) of the circumferential secondary grooves relative to the tire circumferential direction is different from an inclination angle (?1) of portions of the circumferential primary grooves relative to the tire circumferential direction, the portions extending toward the same side as a side in the tire width direction, toward which the circumferential secondary grooves are inclined.

Abstract: A tread pattern of a pneumatic tire comprises shoulder lug grooves that open to ground contact edges; center lug grooves; a pair of circumferential primary grooves with a narrower groove width than the shoulder lug grooves, wherein a portion that bends outward in the tire width direction connects to the shoulder lug grooves and a portion that bends inward in the tire width direction connects to the center lug grooves; and center blocks defined by the center lug grooves and the circumferential primary grooves. The circumferential primary grooves are on opposite sides in the tire width direction in regions spaced from a center line by a distance of from 30% to 60% of half of a tread width T. The ratio of the groove width P3 of the center lug grooves to the maximum length LB in the tire circumferential direction of the center blocks is from 0.03 to 0.07.

Abstract: A tread pattern is provided with: shoulder lug grooves open at ground contact edges; center lug grooves having two ends; circumferential primary grooves formed in a wave-like shape by alternately connecting ends of the center lug grooves and the inner ends in the tire width direction of the shoulder lug grooves; and center blocks defined by the center lug grooves and the pair of circumferential primary grooves. The belt portion of the tire includes first cross belt layers and second cross belt layers. The ratio of the width WB of the center blocks in the tire width direction to the belt width W1 of the belt layer having the shortest width in the tire width direction among the first cross belt layers is in the range from 0.6 to 0.9.

Abstract: Provided is a heavy duty pneumatic tire that includes a tread portion including, in a tread pattern: shoulder lug grooves extending outward in the tire width direction and opening at ground contact edges; a pair of circumferential primary grooves; center lug grooves; center blocks defined by the center lug grooves and the pair of circumferential primary grooves and aligned in the tire circumferential direction; and circumferential secondary grooves extending in the tire circumferential direction in the center block regions and opening to the center lug grooves adjoining the center blocks. The circumferential secondary grooves extend in the tire circumferential direction while changing positions in the tire width direction and each include third groove turning portions formed into a bent shape or a curved shape. The ratio P4/P1 of the width P4 of the circumferential secondary grooves to the width P1 of the circumferential primary grooves is from 0.70 to 1.10.

Abstract: A pneumatic tire having a tread pattern includes: shoulder lug grooves opening at ground contact edges; center lug grooves having both ends; circumferential primary grooves being formed to wave-like shape and alternately connecting the ends of the center lug grooves and inward ends of the shoulder lug grooves in the tire width direction; center blocks formed in a row defined by the center lug grooves and the pair of circumferential primary grooves; and circumferential secondary grooves being formed in regions of the center blocks and interconnecting center lug grooves adjacent in the tire circumferential direction. The circumferential secondary grooves have secondary groove turning portions, and the center lug grooves have lug groove turning portions and connect to the circumferential secondary grooves at the lug groove turning portions.

Abstract: A method comprises obtaining a first cell image of a cell by a first observation method, obtaining a second cell image of the cell by a second observation method that is different from the first observation method, and determining the region of the cell based on the first cell image and the second cell image.

Abstract: The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Abstract: An underfill composition for encapsulating a bond line and a method of using the underfill composition are described. Advantageously, the disclosed underfill composition in an uncured state has a fluidity value of less than about ten minutes over about a two centimeter distance at a temperature of about 90 degrees C. and at a bond line thickness of about 50 microns or less and still have a bulk thermal conductivity that is greater than about 0.8 W/mK in the cured state.

Abstract: Disclosed is a method for analyzing a concentration state of a measurement target component in blood, the method including: obtaining a value regarding an amount of the measurement target component in a collection member in which tissue fluid has been accumulated in advance, the tissue fluid having been extracted for a predetermined extraction time period from an organism which had been subjected to a process for accelerating the extraction of the tissue fluid; obtaining a value of an area under a blood concentration time curve of the measurement target component on the basis of the value regarding the amount of the measurement target component; and calculating a value regarding a ratio of a time period during which a concentration of the measurement target component has exceeded a predetermined concentration relative to the extraction time period, on the basis of the value of the area under the blood concentration time curve.

Abstract: A glucose tolerance analyzer comprising: an accepting section configured to accept inputs of information regarding a type of food or drink ingested by a subject, information regarding an intake amount of the food or drink, and information regarding an amount of glucose in the subject after the ingestion of the food or drink; an output section configured to output an analysis result of glucose tolerance; and a controller configured to: calculate a reference value for analyzing glucose tolerance of the subject based on the accepted information regarding the type of the food or drink ingested by the subject and the information regarding the intake amount of the food or drink, and based on a predetermined index regarding blood glucose increase due to food or drink; analyze the glucose tolerance of the subject based on the accepted information regarding the amount of glucose and based on the calculated reference value; and control the output section to output an obtained analysis result as an analysis result of gl

Abstract: Problem to be Solved The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Abstract: To provide a power supply noise reduction circuit and a power supply noise reduction method that do not require circuit elements to be increased in size and do not cause voltage drop in a power supply voltage. A power supply noise reduction circuit 10 that reduces noise included in a constant voltage output that is output from a power supply 2 to a load includes a first resistor 20 that is inserted into a power supply line L1 extending from the power supply 2 to the load, a filter 31 that is coupled to a load terminal of the first resistor 20 and outputs a first voltage that is obtained by reducing the noise from the constant voltage output, and a unity gain amplifier 32 that drives the first voltage output from the filter 31 and outputs the driven first voltage to the load terminal of the first resistor 20.

Abstract: The pneumatic tire 1 includes the belt layer 14 having the pair of cross belts 142, 143, and a circumferential reinforcing layer 145 disposed between the cross belts 142, 143 or disposed inward in the tire radial direction of the cross belts 142, 143. Moreover, the circumferential reinforcing layer 145 is configured by one wire 1451 that is wound spirally at a slant within a range of ±5 deg with respect to the tire circumferential direction. Moreover, the crossing angle ? in the tire circumferential direction of the wire end portion at the first edge and the wire end portion at the second edge of the circumferential reinforcing layer 145 is within a range of 5 deg???355 deg.

Abstract: A method of predicting viscosity behavior of a thermosetting resin is provided that is capable of predicting viscosity behavior of a thermosetting resin and void generation in the underfill is suppressed while good solder connection is obtained.

Abstract: According to one embodiment, a controller for controlling a connected storage apparatus includes a storage unit and a control unit. The control unit acquires a password input by a user, judges whether or not the password is consistent with a password previously registered in the storage unit, cancels authentication data that is stored in the storage unit and enables reading and writing toward the storage apparatus of data and allows the formatting toward the storage apparatus in a condition that the password is consistent with the password previously registered in the storage unit, and disables reading and writing toward the storage apparatus of data and formatting toward the storage apparatus in a condition that the password is not consistent with the password previously registered in the storage unit.

Abstract: Problem to be Solved The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Abstract: To provide a micropore forming apparatus capable of increasing the amount of interstitial fluid extracted from micropores formed in the skin of a subject. The micropore forming apparatus includes a skin contact part that has a plurality of microneedles for piercing the skin of the subject, and a force exerting part for exerting a force on the skin contact part toward the skin of the subject. The force exerting part is configured so as to exert a force on the microneedles toward the skin at a position at which the microneedles of the skin contact part are to pierce the skin of the subject.

Abstract: A pneumatic tire (1), wherein an inter-cord distance (Gcl) between a circumferential reinforcing layer (145) and an inner-side belt ply (142) at a tire equatorial plane (CL), an inter-cord distance (Gcu) between the circumferential reinforcing layer (145) and an outer-side belt ply (143) at the tire equatorial plane (CL), an inter-cord distance (Gsl) between the circumferential reinforcing layer (145) and the inner-side belt ply (142) at end regions of the circumferential reinforcing layer (145), an inter-cord distance (Gsu) between the circumferential reinforcing layer (145) and the outer-side belt ply (143) at the end regions of the circumferential reinforcing layer (145) have a relationship such that 1.20?(Gcl+Gcu)/(Gsl+Gsu)?9.20.

Abstract: Disclosed is a method for obtaining differentiated cells and/or differentiated cell products, including the steps of: introducing undifferentiated cells into a perfused organ or living tissue; subjecting the undifferentiated cells introduced to perfusion culture together with the organ or living tissue so as to allow the undifferentiated cells to differentiate, thereby obtaining differentiated cells and/or differentiated cell products; collecting a perfusion culture solution that contains the resulting differentiated cells and/or differentiated cell products; and obtaining the differentiated cells and/or differentiated cell products contained in the collected perfusion culture solution.