Patents by Inventor Toshiyuki Toko

Toshiyuki Toko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating diarrhea
    Patent number: 5952380
    Abstract: A pharmaceutical composition for treating diarrhea comprising an anti-diarrhea effective amount of conagenin or a salt thereof, and a pharmaceutically acceptable carrier. The pharmaceutical composition is particularly useful against diarrhea caused by the administration of cancer chemotherapeutic agents.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: September 14, 1999
    Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Taino Pharmaceutical Co., Ltd., Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Masaaki Ishizuka, Kenji Maeda, Tomio Takeuchi, Toshiyuki Toko, Tadayoshi Shiraishi
  • 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid derivative as antitumor agent
    Patent number: 5585373
    Abstract: A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a benzoyl group optionally having one or more substituents or a benzyl group optionally having one or more substituents, R.sub.2 is a hydrogen atom or a carboxyl-protecting group, R.sub.3 is a hydroxyl group, an azido group, a benzenesulfonyloxy group optionally having one or more substituents, a lower alkylsulfonyloxy group optionally having one or more substituents, a tri-substituted silyloxy group or an amino group optionally having one or more substituents, provided that when R.sub.1 and R.sub.2 are hydrogen atoms, R.sub.3 is not an amino group, and a salt thereof.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: December 17, 1996
    Assignee: Taiho Pharmaceutical Co., Ltd
    Inventors: Zhang Z. Ping, Zhen J. Sheng, Zhang Q. Rong, Zhang J. Liang, Singh Rajeshwar, Tomohiro Yamashita, Toshiyuki Toko, Hiroshi Matsumoto
  • 1,1,2-triaryl-1-alkene derivatives
    Patent number: 4897503
    Abstract: This invention provides a 1,1,2-triaryl-1-butene derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, one of R.sub.3 and R.sub.4 is a lower alkyl group and the other is a group of the formula ##STR2## (in which R.sub.5 is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom or --OPO(OH).sub.2 group); or a pharmacologically acceptable salt thereof, its preparation and agents containing the derivative for treating mammary cancer and anovulatory infertility.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: January 30, 1990
    Assignee: Taiho Pharmaceutical
    Inventors: Tetsuji Asao, Setsuo Takeda, Yoshikazu Sugimoto, Toshiyuki Toko, Yuji Yamada, Kazuo Ogawa, Norio Unemi