Patents by Inventor Tove Christensen
Tove Christensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8710205Abstract: The present invention relates to a transcription factor found in filamentous fungi, especially in Aspergillii, DNA sequences coding for said factor, its transformation into and expression in fungal host organisms, and the use of said factor in such hosts for increasing the expression of a polypeptide of interest being produced by said host.Type: GrantFiled: February 20, 2003Date of Patent: April 29, 2014Assignee: Novozymes A/SInventor: Tove Christensen
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Patent number: 8426164Abstract: The present disclosure relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The disclosure also relates to nucleic acid constructs, vectors and host cells including the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides.Type: GrantFiled: March 5, 2009Date of Patent: April 23, 2013Assignee: Novozymes A/SInventors: Carsten M. Hjort, Cees A. M. J. J. Van den Hondel, Peter J. Punt, Frank H. J. Schuren, Tove Christensen
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Patent number: 8088598Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The invention also relates to nucleic acid constructs, vectors and host cells comprising the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides.Type: GrantFiled: December 5, 2003Date of Patent: January 3, 2012Assignee: Novozymes A/SInventors: Carsten M. Hjort, C. A. M. J. J. Van Den Hondel, P. J. Punt, F. H. J. Schuren, Tove Christensen
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Publication number: 20090239260Abstract: The present disclosure relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The disclosure also relates to nucleic acid constructs, vectors and host cells including the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides.Type: ApplicationFiled: March 5, 2009Publication date: September 24, 2009Applicant: Novozymes A/SInventors: Carsten M. Hjort, Cees A.M.J.J. Van Den Hondel, Peter J. Punt, Frank H.J. Schuren, Tove Christensen
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Patent number: 7517668Abstract: A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding functions facilitating gene expression, a suitable marker for selection of transformants, and a DNA-sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in A. oryzae. Examples of such products are chymosin or prochymosin other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus. A preferred promoter is the TAKA-amylase promoter or functional parts thereof. There is also provided a process for the production of a recombinant Humicola lipase. The recombinant Humicola lipase from A. oryzae differs from the native lipase in having a greater glycosylation and in exhibiting an improved thermostability.Type: GrantFiled: May 5, 1995Date of Patent: April 14, 2009Assignee: Novozymes A/SInventors: Esper Boel, Tove Christensen, Helle Fabricius Wöldike
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Patent number: 6806062Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The invention also relates to nucleic acid constructs, vectors and host cells comprising the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides.Type: GrantFiled: March 14, 2000Date of Patent: October 19, 2004Assignee: Novozymes A/SInventors: Carsten M. Hjort, Cees van den Hondel, Peter J. Punt, Frank H. J. Schuren, Tove Christensen
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Publication number: 20040142364Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The invention also relates to nucleic acid constructs, vectors and host cells comprising the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides.Type: ApplicationFiled: December 5, 2003Publication date: July 22, 2004Applicant: Novozymes A/SInventors: Carsten M. Hjort, C.A.M.J.J. van den Hondel, P.J. Punt, F.H.J. Schuren, Tove Christensen
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Publication number: 20030207409Abstract: A method of preparing the sugar 1,5-D-anhydrofructose is described. The method comprises treating an &agr;-1,4-glucan with an &agr;-1,4-glucan lyase wherein the enzyme is used in substantially pure form. In a preferred embodiment, if the glucan contains links other than and in addition to the &agr;-1,4-links, the &agr;-1,4-glucan lyase is used in conjunction with a suitable reagent that can break the other links.Type: ApplicationFiled: May 30, 2003Publication date: November 6, 2003Applicant: DANISCO A/SInventors: Shukun Yu, Kirsten Bojsen, Karsten Kragh, Maja Bojko, John Nielsen, Jan Marcussen, Tove Christensen
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Patent number: 6632643Abstract: A method of preparing the sugar 1,5-D-anhydrofructose is described. The method comprises treating an &agr;-1,4-glucan with an &agr;-1,4-glucan lyase wherein the enzyme is used in substantially pure form. In a preferred embodiment, if the glucan contains links other than and in addition to the &agr;-1,4-links, the &agr;-1,4-glucan lyase is used in conjunction with a suitable reagent that can break the other links.Type: GrantFiled: March 29, 1999Date of Patent: October 14, 2003Assignee: Danisco A/SInventors: Shukun Yu, Kirsten Bojsen, Karsten Kragh, Maja Bojko, John Nielsen, Jan Marcussen, Tove Christensen
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Publication number: 20030148500Abstract: The present invention relates to a transcription factor found in filamentous fungi, especially in Aspergillii, DNA sequences coding for said factor, its transformation into and expression in fungal host organisms, and the use of said factor in such hosts for increasing the expression of a polypeptide of interest being produced by said host.Type: ApplicationFiled: February 20, 2003Publication date: August 7, 2003Applicant: Novozymes A/SInventor: Tove Christensen
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Patent number: 6555657Abstract: The present invention relates to a transcription factor found in filamentous fungi, especially in Aspergillii, DNA sequences coding for said factor, its transformation into and expression in fungal host organisms, and the use of said factor in such hosts for increasing the expression of a polypeptide of interest being produced by said host.Type: GrantFiled: August 1, 2001Date of Patent: April 29, 2003Assignee: Novozymes, A/SInventor: Tove Christensen
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Publication number: 20020151073Abstract: The present invention relates to a transcription factor found in filamentous fungi, especially in Aspergillii, DNA sequences coding for said factor, its transformation into and expression in fungal host organisms, and the use of said factor in such hosts for increasing the expression of a polypeptide of interest being produced by said host.Type: ApplicationFiled: August 1, 2001Publication date: October 17, 2002Applicant: Novozymes A/SInventor: Tove Christensen
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Publication number: 20020142403Abstract: A method of preparing the sugar 1,5-D-anhydrofructose is described. The method comprises treating an alpha -1,4-glucan with an alpha -1,4-glucan lyase wherein the enzyme is used in substantially pure form. In a preferred embodiment, if the glucan contains links other than and in addition to the alpha -1,4-links, the alpha -1,4-glucan lyase is used in conjunction with a suitable reagent that can break the other links.Type: ApplicationFiled: March 29, 1999Publication date: October 3, 2002Inventors: SHUKUN YU, KIRSTEN BOJSEN, KARSTEN KRAGH, MAJA BOJKO, JOHN NIELSON, JAN MARCUSSEN, TOVE CHRISTENSEN
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Patent number: 6316220Abstract: A transcription factor found in filamentous fungi, especially in Aspergillii, DNA sequences coding for said factor, its transformation into and expression in fungal host organisms, and the use of said factor in such hosts for increasing the expression of a polypeptide of interest being produced by said host.Type: GrantFiled: November 23, 1998Date of Patent: November 13, 2001Assignee: Novozymes A/SInventor: Tove Christensen
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Patent number: 6156553Abstract: The present invention relates to a cloned DNA sequence encoding an enzyme with dextranase activity, a recombinant expression vector comprising said DNA sequence, a filamentous fungus host cell, a method for producing said recombinant dextranase, and the isolated and purified enzyme.The invention also relates to compositions comprising the recombinant enzyme, oral care compositions and products and the use for removing of dental plaque.Type: GrantFiled: December 21, 1998Date of Patent: December 5, 2000Assignee: Novo Nordisk A/SInventors: Tove Christensen, Claus Crone Fuglsang, Torben Halkier, Charlotte Johansen
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Patent number: 6025185Abstract: A modified Aspergillus oryzae cell having an area gene which does not express a functional AreA activator, DNA sequences encoding the area gene, and method for using the cell of the invention for production of a heterologous polypeptide.Type: GrantFiled: December 3, 1996Date of Patent: February 15, 2000Assignee: Novo Nordisk AlsInventors: Tove Christensen, Michael J. Hynes
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Patent number: 6013452Abstract: The present invention relates to fungi, which do not produce proteases. The fungi of the invention are useful as hosts for the production of proteins susceptible of proteolytic degradation by the proteases usually produced, and the invention consequently encompasses processes for the production of proteins of interest in high yields by using the fungi of the invention. The invention also comprises methods for producing such fungi and DNA constructs to be used in these methods.Type: GrantFiled: May 14, 1998Date of Patent: January 11, 2000Assignee: Novo Nordisk A/SInventors: Tove Christensen, Jan Lehmbeck
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Patent number: 5965384Abstract: A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA sequences encoding functions facilitating gene expression, a suitable marker for selection of transformants, and a DNA sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in A. oryzae. Examples of such products are chymosin or prochymosin and other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus. A preferred promoter is the TAKA-amylase promoter or functional parts thereof. There is also provided a process for the production of a recombinant Humicola lipase. The recombinant Humicola lipase from A. oryzae differs from the native lipase in having a greater glycosylation and in exhibiting an improved thermostability.Type: GrantFiled: June 5, 1995Date of Patent: October 12, 1999Assignee: Novo Nordisk A/SInventors: Esper Boel, Tove Christensen, Helle Fabricius Woldike, Ida Birgitte Huge-Jensen
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Patent number: 5908760Abstract: A method of preparing .varies.-glucan lyase enzymes is described. The method comprises isolating the enzymes from a culture of fungus wherein the culture is substantially free of any other organisms. Also described are the amino acid sequences for the enzymes and their coding sequences.Type: GrantFiled: July 8, 1996Date of Patent: June 1, 1999Assignee: Danisco A/SInventors: Kirsten Bojsen, Shukun Yu, Karsten Kragh, Tove Christensen, Jan Marcussen
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Patent number: 5874558Abstract: A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding functions facilitating gene expression, a suitable marker for selection of transformants, and a DNA-sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in A. oryzae. Examples of such products are chymosin or prochymosin and other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus. A preferred promoter is the TAKA-amylase promoter or functional parts thereof. There is also provided a process for the production of a recombinant Humicola lipase. The recombinant Humicola lipase from A. oryzae differs from the native lipase in having a greater glycosylation and in exhibiting an improved thermostability.Type: GrantFiled: May 17, 1996Date of Patent: February 23, 1999Assignee: Novo NordiskInventors: Esper Boel, Tove Christensen, Helle Fabricius Woldike