Abstract: A package with multiple chambers, wherein the inside of the package is partitioned into multiple chambers by a weak seal part(s) formed by sealing one sheet having a heat seal layer in at least one surface thereof and the other sheet having a heat seal layer in at least one surface thereof with the heat seal layers facing each other and sealing the peripheral edge parts thereof, and heat-pressing, from the outside of the package, a part of the inner surfaces of the walls of the package with the heat seal layers. The package is characterized in that both of two heat seal layers forming the inner surfaces of the walls include only a cyclic polyolefin resin as a resin ingredient.

Abstract: A multilayered liquid container having a discharge port welded under specified conditions to a sealant, which is constituted of a resin comprising a cycloolefin resin as a main component. The discharge port is composed of: an innermost layer constituted of a resin comprising a cycloolefin as a main component; and a surface layer whose main part is constituted of a resin comprising a specific type of polyethylene as a main component. According to the present invention, there can be provided a multilayered liquid container, which can prevent an effective component of a content fluid from being adsorbed onto or penetrating through not only the container body, but also the resin constituting the discharge port, and enables high temperature sterilization treatment, coupled with the discharge port having high welded strength and drop strength.

Abstract: A pouring port of a container for liquid at one end of which a rubber stopper allowing the penetration of an injection needle therethrough is embedded, wherein: the pouring port is formed by welding a port part, at least the innermost layer of which forming the discharge channel thereof comprises a resin containing a COP-based resin as the main component, with a stopper body part, which holds the rubber stopper and comprises a resin containing a COP-based resin as the main component, via the resin layers containing the respective COP-based resins as the main component; and at least the resin constituting the stopper body part contains a rubber component in an amount of not more than 30% by mass, or has, in the main chain, a molecular structure represented by general formula (1) [wherein R represents a hydrogen atom or an organic group having 1 to 20 carbon atoms; and n represents an integer equal to or greater than 1] and contains a PE-based resin in an amount of 30% by mass or less, and/or contains an an

Abstract: A medical container comprising a body for containing a medicament, the body of the medical container being formed of a multilayered film comprising (i) a layer formed of a linear polyolefin and (ii) a layer formed of a cyclic polyolefin adjacent to the layer (i), and the layer (i) formed of the linear polyolefin satisfying the following conditions (a) and/or (b): Condition (a): an amount of a liquid component, which remains after Soxhlet's extraction with organic solvents followed by evaporation of the solvents, is 0.2% by weight or less, and Condition (b): a branching degree of a component, which remains after Soxhlet's extraction with n-hexane followed by evaporation of n-hexane, is 50 or less per 1,000 carbon atoms.

Abstract: Multi-chamber container (1) having its interior partitioned by weak seal portions (3) provided through detachable heat sealing so that multiple contents are accommodated separately from each other, wherein use is made of heat seal layers consisting of a composition comprising two types of propylene copolymers components (component A and component B) from propylene and ethylene and/or a C4-C8 ?-olefin which have the following elution properties. Thus, a region wherein a change of seal strength by a change of heat seal temperature is small has a wide temperature range to thereby facilitate controlling of the seal strength at the weak seal portions. The proportion (mass %) of, to total solution, elution according to the TREF method (temperature: 0 to 140° C. and solvent: ODCB) is as follows. With respect to component A: 15 to 50 at 0° C., and 5 to less than 15 at 60 to 90° C. With respect to component B: 0 to 25 at 0° C., and 15 to 70 at 60 to 90° C.

Abstract: A multilayered liquid container having a discharge port welded under specified conditions to a sealant, which is constituted of a resin comprising a cycloolefin resin as a main component. The discharge port is composed of: an innermost layer constituted of a resin comprising a cycloolefin as a main component; and a surface layer whose main part is constituted of a resin comprising a specific type of polyethylene as a main component. According to the present invention, there can be provided a multilayered liquid container, which can prevent an effective component of a content fluid from being adsorbed onto or penetrating through not only the container body, but also the resin constituting the discharge port, and enables high temperature sterilization treatment, coupled with the discharge port having high welded strength and drop strength.

Abstract: To provide a liquid container, which exhibits excellent storage stability and impact resistance and which can be used for producing a soft bag pharmaceutical product of an injection liquid containing nitroglycerin, a protein, hyaluronic acid, a vitamin, a trace element, a radical scavenger, and the like. The liquid container of the invention formed of a multilayer film and/or multilayer sheet, characterized in that the multilayer film and/or multilayer sheet has a barrier layer containing, as a predominant component, a polycycloolefin-based resin having a glass transition temperature higher by 5° C. or more than the temperature at which the container is subjected to thermal treatment or high-pressure steam sterilization, and a seal layer containing, as a predominant component, a polyethylene-based resin or a polypropylene-based resin, and the barrier layer being provided adjacent to the seal layer.

Abstract: This invention provides a duplex-chamber package that has a high level of water vapor barrier properties, can realize mixing of plural contents in a hermetically sealed state, and can reduce the elution of a material contained in the sheet of a duplex-chamber package material into the contents of the package. The duplex-chamber package comprises a package comprising a first sheet superimposed onto a second sheet, the peripheral part of the assembly having been sealed, a weakly sealed part for partitioning the inside of the package into two or more chambers having been provided in a part of the package. The first sheet (I) is a laminated sheet comprising a heat seal layer, a mass transfer layer and a mass transfer blocking layer, and the mass transfer blocking layer being interposed between the heat seal layer and the mass transfer layer.

Abstract: A medical container comprising a body for containing a medicament, the body of the medical container being formed of a multilayered film comprising (i) a layer formed of a linear polyolefin and (ii) a layer formed of a cyclic polyolefin adjacent to the layer (i), and the layer (i) formed of the linear polyolefin satisfying the following conditions (a) and/or (b): Condition (a): an amount of a liquid component, which remains after Soxhlet's extraction with organic solvents followed by evaporation of the solvents, is 0.2% by weight or less, and Condition (b): a branching degree of a component, which remains after Soxhlet's extraction with n-hexane followed by evaporation of n-hexane, is 50 or less per 1,000 carbon atoms.

Abstract: Multi-chamber container (1) having its interior partitioned by weak seal portions (3) provided through detachable heat sealing so that multiple contents are accommodated separately from each other, wherein use is made of heat seal layers consisting of a composition comprising two types of propylene copolymers components (component A and component B) from propylene and ethylene and/or a C4-C8 ?-olefin which have the following elution properties. Thus, a region wherein a change of seal strength by a change of heat seal temperature is small has a wide temperature range to thereby facilitate controlling of the seal strength at the weak seal portions. The proportion (mass %) of, to total solution, elution according to the TREF method (temperature: 0 to 140° C. and solvent: ODCB) is as follows. With respect to component A: 15 to 50 at 0° C., and 5 to less than 15 at 60 to 90° C. With respect to component B: 0 to 25 at 0° C., and 15 to 70 at 60 to 90° C.

Abstract: A package with multiple chambers, wherein the inside of the package is partitioned into multiple chambers by a weak seal part(s) formed by sealing one sheet having a heat seal layer in at least one surface thereof and the other sheet having a heat seal layer in at least one surface thereof with the heat seal layers facing each other and sealing the peripheral edge parts thereof, and heat-pressing, from the outside of the package, a part of the inner surfaces of the walls of the package with the heat seal layers. The package is characterized in that both of two heat seal layers forming the inner surfaces of the walls include only a cyclic polyolefin resin as a resin ingredient.

Abstract: A packaging bag, characterized in that it comprises 2 sheets of resin film (2,2) having innermost layers (2a, 2a) made from one or more resins selected from the group consisting of a polyester, a polyamide, a polyacrylonitrile, a polycarbonate, a cyclic polyolefin and a polyfluoroethylene, the 2 sheets of resin film are arranged so that the innermost layers (2a, 2a) face each other in the inner sides thereof, and peripheral edge portions of the two resin films (2,2) are bound to each other via a peripheral edge adhesion section (3) comprising a thermoplastic resin capable of melting and adhering to the resin films (2, 2).

Abstract: A plastic film for medical liquid containers which includes at least thee layers, each layer not containing non-elastomeric block copolymer of benzene-ring-free olefin and propylene, such that the first layer, which is composed mainly of propylene homopolymer, the second layer, which contains polypropylene resin, polyethylene resin, and thermoplastic elastomer, and the third layer, which functions as a sealing layer and is composed mainly of copolymer of propylene and other monomers, are laminated without the aid of bonding layer, with the second layer acting as an intermediate layer.

Abstract: A method for the refinement of a thrombin substrate, characterized by comprising therein a step of affinity chromatography formed by using an affinity adsorbent having as a ligand a thrombin or thrombin analogue deprived of nucleophilicity (activity) without causing stereostructure to the linkage with a substrate is disclosed.

Abstract: A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields.The method comprises(A) a step of causing an active serine residue site of thrombin to react with an inhibitor,(B) a step of performing an alkali treatment at a pH of not less than 11, and(C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.

Abstract: A method for the production of a microsphere without use of a dispersion stabilizer is disclosed which permits the microsphere to be produced in the form of discrete particles readily treatable for purification. The method which produces this microsphere comprises the steps of dissolving in an organic solvent such as an alcohol a monomer mixture including an ethylenically unsaturated amide and 10 to 70% by weight, based on 100% by weight of said monomer mixture, of a cross-linking agent thereby preparing a mixed solution, keeping said mixed solution at a temperature in the range of from 30.degree. to 95.degree. C., and adding thereto at least one initiator selected from the group consisting of peroxide type initiators and azo type initiators in an amount such as to be contained therein at a final concentration in the range of from 1.times.10.sup.-5 to 8.times.10.sup.-2 mol/liter thereby inducing polymerization of said monomer mixture.